PDCD5 — 16 ClinVar variants
All ClinVar germline PDCD5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
2 Benign · 14 Uncertain significance
Full PDCD5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDCD5 p.Ala27Val Uncertain significance Single submitter
- PDCD5 p.Arg53Trp Uncertain significance Single submitter
- PDCD5 p.Ile93Val Uncertain significance Single submitter
- PDCD5 p.Ile95Thr Uncertain significance Single submitter
- PDCD5 p.Leu17Pro Uncertain significance Single submitter
- PDCD5 p.Leu6Phe Uncertain significance Single submitter
- PDCD5 p.Leu74Arg Uncertain significance Single submitter
- PDCD5 p.Met117Thr Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PDCD5 variants
Benign 2
- c.105-7G>A Multiple submitters
- p.Glu16Lys Multiple submitters ⚠
Uncertain significance 14
- p.Ala27Val Single submitter ⚠
- p.Arg10Gly Single submitter ⚠
- p.Arg53Gln Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Asp122Tyr Single submitter ⚠
- p.Gln101Arg Single submitter ⚠
- p.Ile93Val Single submitter ⚠
- p.Ile95Thr Single submitter ⚠
- p.Leu17Pro Single submitter ⚠
- p.Leu6Phe Single submitter ⚠
- p.Leu74Arg Single submitter ⚠
- p.Lys105Asn Single submitter
- p.Met117Thr Single submitter ⚠
- p.Thr103Ile Single submitter