PDCD6 — 24 ClinVar variants
All ClinVar germline PDCD6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full PDCD6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDCD6 p.Ala118Thr Uncertain significance Single submitter
- PDCD6 p.Arg100Cys Uncertain significance Single submitter
- PDCD6 p.Arg125Trp Uncertain significance Single submitter
- PDCD6 p.Asp139Gly Uncertain significance Single submitter
- PDCD6 p.Cys155Phe Uncertain significance Single submitter
- PDCD6 p.Ile110Met Uncertain significance Single submitter
- PDCD6 p.Ile164Val Uncertain significance Single submitter
- PDCD6 p.Leu126Pro Uncertain significance Single submitter
- PDCD6 p.Met186Thr Uncertain significance Single submitter
- PDCD6 p.Phe138Ser Uncertain significance Single submitter
- PDCD6 p.Phe188Val Uncertain significance Single submitter
- PDCD6 p.Thr101Ala Uncertain significance Single submitter
- PDCD6 p.Thr101Met Uncertain significance Single submitter
- PDCD6 p.Thr162Met Uncertain significance Single submitter
- PDCD6 p.Val157Phe Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- PDCD6 p.Arg136Gln Uncertain significance Single submitter
- PDCD6 p.Asn54Lys Uncertain significance Single submitter
- PDCD6 p.Asn54Ser Uncertain significance Single submitter
- PDCD6 p.Gln50Arg Uncertain significance Single submitter
- PDCD6 p.Leu52Phe Uncertain significance Single submitter
- PDCD6 p.Leu52Val Uncertain significance Single submitter
- PDCD6 p.Ser53Thr Uncertain significance Single submitter
- PDCD6 p.Thr56Lys Uncertain significance Single submitter
All PDCD6 variants
Likely benign 1
- p.Val35= Single submitter
Uncertain significance 23
- p.Ala118Thr Single submitter ⚠
- p.Arg100Cys Single submitter ⚠
- p.Arg125Trp Single submitter ⚠
- p.Arg136Gln Single submitter ⚠
- p.Asn54Lys Single submitter ⚠
- p.Asn54Ser Single submitter ⚠
- p.Asp139Gly Single submitter ⚠
- p.Cys155Phe Single submitter ⚠
- p.Gln50Arg Single submitter ⚠
- p.Ile110Met Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Leu126Pro Single submitter ⚠
- p.Leu52Phe Single submitter ⚠
- p.Leu52Val Single submitter ⚠
- p.Met186Thr Single submitter ⚠
- p.Phe138Ser Single submitter ⚠
- p.Phe188Val Single submitter ⚠
- p.Ser53Thr Single submitter ⚠
- p.Thr101Ala Single submitter ⚠
- p.Thr101Met Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr56Lys Single submitter ⚠
- p.Val157Phe Single submitter ⚠