PDE3B — 173 ClinVar variants
All ClinVar germline PDE3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 155 flagged for review →
9 Benign · 11 Likely benign · 153 Uncertain significance
Full PDE3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 155
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 109
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDE3B p.Thr137Ala Uncertain significance Multiple submitters
- PDE3B p.Ala102Gly Uncertain significance Single submitter
- PDE3B p.Ala106Ser Uncertain significance Single submitter
- PDE3B p.Ala128Gly Uncertain significance Single submitter
- PDE3B p.Ala128Thr Uncertain significance Single submitter
- PDE3B p.Ala159Val Uncertain significance Single submitter
- PDE3B p.Ala194Val Uncertain significance Single submitter
- PDE3B p.Ala20Ser Uncertain significance Single submitter
- PDE3B p.Ala272Glu Uncertain significance Single submitter
- PDE3B p.Ala272Val Uncertain significance Single submitter
- PDE3B p.Ala507Ser Uncertain significance Single submitter
- PDE3B p.Ala748Glu Uncertain significance Single submitter
- PDE3B p.Ala785Pro Uncertain significance Single submitter
- PDE3B p.Ala813Asp Uncertain significance Single submitter
- PDE3B p.Ala818Pro Uncertain significance Single submitter
- PDE3B p.Ala84Val Uncertain significance Single submitter
- PDE3B p.Ala91Val Uncertain significance Single submitter
- PDE3B p.Arg12Leu Uncertain significance Single submitter
- PDE3B p.Arg138Gln Uncertain significance Single submitter
- PDE3B p.Arg270Gly Uncertain significance Single submitter
- PDE3B p.Arg277Gly Uncertain significance Single submitter
- PDE3B p.Arg290Gly Uncertain significance Single submitter
- PDE3B p.Arg360Pro Uncertain significance Single submitter
- PDE3B p.Arg381Pro Uncertain significance Single submitter
- PDE3B p.Arg458His Uncertain significance Single submitter
- PDE3B p.Arg458Pro Uncertain significance Single submitter
- PDE3B p.Arg532Gln Uncertain significance Single submitter
- PDE3B p.Arg53Gly Uncertain significance Single submitter
- PDE3B p.Arg725His Uncertain significance Single submitter
- PDE3B p.Arg77Gly Uncertain significance Single submitter
- PDE3B p.Arg77Leu Uncertain significance Single submitter
- PDE3B p.Arg77Pro Uncertain significance Single submitter
- PDE3B p.Arg828Gly Uncertain significance Single submitter
- PDE3B p.Asn607Thr Uncertain significance Single submitter
- PDE3B p.Asn771Asp Uncertain significance Single submitter
- PDE3B p.Asn780Lys Uncertain significance Single submitter
- PDE3B p.Asp1027Gly Uncertain significance Single submitter
- PDE3B p.Asp18Asn Uncertain significance Single submitter
- PDE3B p.Asp421Val Uncertain significance Single submitter
- PDE3B p.Asp593Gly Uncertain significance Single submitter
- PDE3B p.Asp776His Uncertain significance Single submitter
- PDE3B p.Asp894Asn Uncertain significance Single submitter
- PDE3B p.Cys1082Arg Uncertain significance Single submitter
- PDE3B p.Cys127Tyr Uncertain significance Single submitter
- PDE3B p.Cys203Ser Uncertain significance Single submitter
- PDE3B p.Cys475Arg Uncertain significance Single submitter
- PDE3B p.Gln268Glu Uncertain significance Single submitter
- PDE3B p.Gln41Pro Uncertain significance Single submitter
- PDE3B p.Gln762Arg Uncertain significance Single submitter
- PDE3B p.Gln930His Uncertain significance Single submitter
- PDE3B p.Glu25Gly Uncertain significance Single submitter
- PDE3B p.Glu414Gly Uncertain significance Single submitter
- PDE3B p.Glu58Asp Uncertain significance Single submitter
- PDE3B p.Gly1030Ser Uncertain significance Single submitter
- PDE3B p.Gly104Glu Uncertain significance Single submitter
- PDE3B p.Gly142Arg Uncertain significance Single submitter
- PDE3B p.Gly150Asp Uncertain significance Single submitter
- PDE3B p.Gly30Arg Uncertain significance Single submitter
- PDE3B p.Gly730Ala Uncertain significance Single submitter
- PDE3B p.Gly768Glu Uncertain significance Single submitter
- PDE3B p.Gly83Ser Uncertain significance Single submitter
- PDE3B p.His218Tyr Uncertain significance Single submitter
- PDE3B p.His275Tyr Uncertain significance Single submitter
- PDE3B p.His50Arg Uncertain significance Single submitter
- PDE3B p.Ile377Val Uncertain significance Single submitter
- PDE3B p.Ile535Lys Uncertain significance Single submitter
- PDE3B p.Leu119Phe Uncertain significance Single submitter
- PDE3B p.Leu244Val Uncertain significance Single submitter
- PDE3B p.Leu247Pro Uncertain significance Single submitter
- PDE3B p.Leu27Val Uncertain significance Single submitter
- PDE3B p.Leu51Phe Uncertain significance Single submitter
- PDE3B p.Lys611Thr Uncertain significance Single submitter
- PDE3B p.Lys615Arg Uncertain significance Single submitter
- PDE3B p.Met1040Arg Uncertain significance Single submitter
- PDE3B p.Met1040Val Uncertain significance Single submitter
- PDE3B p.Met387Ile Uncertain significance Single submitter
- PDE3B p.Phe228Leu Uncertain significance Single submitter
- PDE3B p.Phe47Cys Uncertain significance Single submitter
- PDE3B p.Phe481Leu Uncertain significance Single submitter
- PDE3B p.Phe564Leu Uncertain significance Single submitter
- PDE3B p.Phe88Ile Uncertain significance Single submitter
- PDE3B p.Pro121Ser Uncertain significance Single submitter
- PDE3B p.Pro121Thr Uncertain significance Single submitter
- PDE3B p.Pro213Arg Uncertain significance Single submitter
- PDE3B p.Pro23Ser Uncertain significance Single submitter
- PDE3B p.Pro273Ser Uncertain significance Single submitter
- PDE3B p.Pro291Ser Uncertain significance Single submitter
- PDE3B p.Pro396Thr Uncertain significance Single submitter
- PDE3B p.Pro403Leu Uncertain significance Single submitter
- PDE3B p.Pro562Leu Uncertain significance Single submitter
- PDE3B p.Pro74Arg Uncertain significance Single submitter
- PDE3B p.Pro98Arg Uncertain significance Single submitter
- PDE3B p.Ser148Arg Uncertain significance Single submitter
- PDE3B p.Ser151Cys Uncertain significance Single submitter
- PDE3B p.Ser151Thr Uncertain significance Single submitter
- PDE3B p.Ser26Asn Uncertain significance Single submitter
- PDE3B p.Ser280Arg Uncertain significance Single submitter
- PDE3B p.Ser310Arg Uncertain significance Single submitter
- PDE3B p.Ser65Pro Uncertain significance Single submitter
- PDE3B p.Ser775Pro Uncertain significance Single submitter
- PDE3B p.Thr110Pro Uncertain significance Single submitter
- PDE3B p.Thr209Ala Uncertain significance Single submitter
- PDE3B p.Thr487Ser Uncertain significance Single submitter
- PDE3B p.Thr499Ile Uncertain significance Single submitter
- PDE3B p.Trp107Ser Uncertain significance Single submitter
- PDE3B p.Trp176Cys Uncertain significance Single submitter
- PDE3B p.Tyr308Cys Uncertain significance Single submitter
- PDE3B p.Val1104Ile Uncertain significance Single submitter
- PDE3B p.Val57Met Uncertain significance Single submitter
Predictors split 46
The independent predictors disagree with each other — read with care.
- PDE3B p.Glu1015Lys Benign Multiple submitters
- PDE3B p.Ala813Gly Uncertain significance Single submitter
- PDE3B p.Ala889Thr Uncertain significance Single submitter
- PDE3B p.Arg1056Gln Likely benign Single submitter
- PDE3B p.Arg196Ser Uncertain significance Single submitter
- PDE3B p.Arg217Trp Uncertain significance Single submitter
- PDE3B p.Arg360Cys Uncertain significance Single submitter
- PDE3B p.Arg45Cys Uncertain significance Single submitter
- PDE3B p.Arg865His Uncertain significance Single submitter
- PDE3B p.Arg865Leu Uncertain significance Single submitter
- PDE3B p.Asp1019His Uncertain significance Single submitter
- PDE3B p.Asp1085Gly Uncertain significance Single submitter
- PDE3B p.Cys219Trp Uncertain significance Single submitter
- PDE3B p.Cys792Arg Uncertain significance Single submitter
- PDE3B p.Glu1032Gln Uncertain significance Single submitter
- PDE3B p.Glu1036Lys Uncertain significance Single submitter
- PDE3B p.Glu904Gln Uncertain significance Single submitter
- PDE3B p.Glu953Gly Uncertain significance Single submitter
- PDE3B p.Gly262Val Uncertain significance Single submitter
- PDE3B p.Ile1102Phe Uncertain significance Single submitter
- PDE3B p.Ile734Met Uncertain significance Single submitter
- PDE3B p.Ile890Val Uncertain significance Single submitter
- PDE3B p.Leu1033Phe Uncertain significance Single submitter
- PDE3B p.Leu111Arg Uncertain significance Single submitter
- PDE3B p.Leu155Gln Uncertain significance Single submitter
- PDE3B p.Leu237Val Uncertain significance Single submitter
- PDE3B p.Leu244Phe Uncertain significance Single submitter
- PDE3B p.Leu746Ile Uncertain significance Single submitter
- PDE3B p.Phe131Cys Uncertain significance Single submitter
- PDE3B p.Phe390Leu Uncertain significance Single submitter
- PDE3B p.Phe404Leu Uncertain significance Single submitter
- PDE3B p.Pro189Thr Uncertain significance Single submitter
- PDE3B p.Pro23Thr Uncertain significance Single submitter
- PDE3B p.Pro370Thr Uncertain significance Single submitter
- PDE3B p.Pro374Ser Uncertain significance Single submitter
- PDE3B p.Pro489Leu Uncertain significance Single submitter
- PDE3B p.Pro795Ser Uncertain significance Single submitter
- PDE3B p.Ser345Tyr Uncertain significance Single submitter
- PDE3B p.Ser379Cys Uncertain significance Single submitter
- PDE3B p.Ser37Arg Uncertain significance Single submitter
- PDE3B p.Ser382Ile Uncertain significance Single submitter
- PDE3B p.Ser441Arg Uncertain significance Single submitter
- PDE3B p.Ser573Arg Uncertain significance Single submitter
- PDE3B p.Ser793Cys Uncertain significance Single submitter
- PDE3B p.Thr209Met Uncertain significance Single submitter
- PDE3B p.Val32Gly Uncertain significance Single submitter
All PDE3B variants
Benign 9
- p.Ala255= Multiple submitters
- p.Asn910= Multiple submitters
- p.Glu1015Lys Multiple submitters ⚠
- p.Ile887= Multiple submitters
- c.1956+9T>C Single submitter
- c.2724+9T>C Single submitter
- p.Asn852= Single submitter
- p.Glu1092Gln Single submitter
- p.Pro1049= Single submitter
Likely benign 11
- p.Arg1056Gln Single submitter ⚠
- p.Glu191Ala Single submitter
- p.Glu606Asp Single submitter
- p.Gly250Cys Single submitter
- p.His521Tyr Single submitter
- p.Lys639Asn Single submitter
- p.Met583Thr Single submitter
- p.Ser789= Single submitter
- p.Thr526Ala Single submitter
- p.Val496Ile Single submitter
- p.Val549Ile Single submitter
Uncertain significance 153
- p.Thr137Ala Multiple submitters ⚠
- p.Ala102Gly Single submitter ⚠
- p.Ala106Ser Single submitter ⚠
- p.Ala128Gly Single submitter ⚠
- p.Ala128Thr Single submitter ⚠
- p.Ala159Val Single submitter ⚠
- p.Ala194Val Single submitter ⚠
- p.Ala20Ser Single submitter ⚠
- p.Ala272Glu Single submitter ⚠
- p.Ala272Val Single submitter ⚠
- p.Ala507Ser Single submitter ⚠
- p.Ala748Glu Single submitter ⚠
- p.Ala785Pro Single submitter ⚠
- p.Ala813Asp Single submitter ⚠
- p.Ala813Gly Single submitter ⚠
- p.Ala818Pro Single submitter ⚠
- p.Ala84Val Single submitter ⚠
- p.Ala889Thr Single submitter ⚠
- p.Ala91Val Single submitter ⚠
- p.Arg12Leu Single submitter ⚠
- p.Arg138Gln Single submitter ⚠
- p.Arg196Ser Single submitter ⚠
- p.Arg217Trp Single submitter ⚠
- p.Arg270Gly Single submitter ⚠
- p.Arg277Gly Single submitter ⚠
- p.Arg290Gly Single submitter ⚠
- p.Arg360Cys Single submitter ⚠
- p.Arg360Pro Single submitter ⚠
- p.Arg381Pro Single submitter ⚠
- p.Arg458His Single submitter ⚠
- p.Arg458Pro Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Arg532Gln Single submitter ⚠
- p.Arg53Gly Single submitter ⚠
- p.Arg725His Single submitter ⚠
- p.Arg77Gly Single submitter ⚠
- p.Arg77Leu Single submitter ⚠
- p.Arg77Pro Single submitter ⚠
- p.Arg828Gly Single submitter ⚠
- p.Arg865His Single submitter ⚠
- p.Arg865Leu Single submitter ⚠
- p.Asn607Thr Single submitter ⚠
- p.Asn771Asp Single submitter ⚠
- p.Asn780Lys Single submitter ⚠
- p.Asp1019His Single submitter ⚠
- p.Asp1027Gly Single submitter ⚠
- p.Asp1085Gly Single submitter ⚠
- p.Asp18Asn Single submitter ⚠
- p.Asp421Val Single submitter ⚠
- p.Asp593Gly Single submitter ⚠
- p.Asp776His Single submitter ⚠
- p.Asp894Asn Single submitter ⚠
- p.Cys1082Arg Single submitter ⚠
- p.Cys127Tyr Single submitter ⚠
- p.Cys203Ser Single submitter ⚠
- p.Cys219Trp Single submitter ⚠
- p.Cys475Arg Single submitter ⚠
- p.Cys792Arg Single submitter ⚠
- p.Gln268Glu Single submitter ⚠
- p.Gln41Pro Single submitter ⚠
- p.Gln762Arg Single submitter ⚠
- p.Gln930His Single submitter ⚠
- p.Glu1032Gln Single submitter ⚠
- p.Glu1036Lys Single submitter ⚠
- p.Glu25Gly Single submitter ⚠
- p.Glu414Gly Single submitter ⚠
- p.Glu58Asp Single submitter ⚠
- p.Glu904Gln Single submitter ⚠
- p.Glu953Gly Single submitter ⚠
- p.Gly1030Ser Single submitter ⚠
- p.Gly104Glu Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly150Asp Single submitter ⚠
- p.Gly262Val Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly730Ala Single submitter ⚠
- p.Gly768Glu Single submitter ⚠
- p.Gly83Ser Single submitter ⚠
- p.His218Tyr Single submitter ⚠
- p.His275Tyr Single submitter ⚠
- p.His50Arg Single submitter ⚠
- p.Ile1102Phe Single submitter ⚠
- p.Ile377Val Single submitter ⚠
- p.Ile535Lys Single submitter ⚠
- p.Ile734Met Single submitter ⚠
- p.Ile890Val Single submitter ⚠
- p.Leu1033Phe Single submitter ⚠
- p.Leu111Arg Single submitter ⚠
- p.Leu119Phe Single submitter ⚠
- p.Leu155Gln Single submitter ⚠
- p.Leu237Val Single submitter ⚠
- p.Leu244Phe Single submitter ⚠
- p.Leu244Val Single submitter ⚠
- p.Leu247Pro Single submitter ⚠
- p.Leu27Val Single submitter ⚠
- p.Leu51Phe Single submitter ⚠
- p.Leu746Ile Single submitter ⚠
- p.Lys611Thr Single submitter ⚠
- p.Lys615Arg Single submitter ⚠
- p.Met1040Arg Single submitter ⚠
- p.Met1040Val Single submitter ⚠
- p.Met387Ile Single submitter ⚠
- p.Phe131Cys Single submitter ⚠
- p.Phe228Leu Single submitter ⚠
- p.Phe390Leu Single submitter ⚠
- p.Phe404Leu Single submitter ⚠
- p.Phe47Cys Single submitter ⚠
- p.Phe481Leu Single submitter ⚠
- p.Phe564Leu Single submitter ⚠
- p.Phe88Ile Single submitter ⚠
- p.Pro121Ser Single submitter ⚠
- p.Pro121Thr Single submitter ⚠
- p.Pro189Thr Single submitter ⚠
- p.Pro213Arg Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Pro23Thr Single submitter ⚠
- p.Pro273Ser Single submitter ⚠
- p.Pro291Ser Single submitter ⚠
- p.Pro370Thr Single submitter ⚠
- p.Pro374Ser Single submitter ⚠
- p.Pro396Thr Single submitter ⚠
- p.Pro403Leu Single submitter ⚠
- p.Pro489Leu Single submitter ⚠
- p.Pro562Leu Single submitter ⚠
- p.Pro74Arg Single submitter ⚠
- p.Pro795Ser Single submitter ⚠
- p.Pro98Arg Single submitter ⚠
- p.Ser148Arg Single submitter ⚠
- p.Ser151Cys Single submitter ⚠
- p.Ser151Thr Single submitter ⚠
- p.Ser26Asn Single submitter ⚠
- p.Ser280Arg Single submitter ⚠
- p.Ser310Arg Single submitter ⚠
- p.Ser345Tyr Single submitter ⚠
- p.Ser379Cys Single submitter ⚠
- p.Ser37Arg Single submitter ⚠
- p.Ser382Ile Single submitter ⚠
- p.Ser441Arg Single submitter ⚠
- p.Ser573Arg Single submitter ⚠
- p.Ser65Pro Single submitter ⚠
- p.Ser775Pro Single submitter ⚠
- p.Ser793Cys Single submitter ⚠
- p.Thr110Pro Single submitter ⚠
- p.Thr209Ala Single submitter ⚠
- p.Thr209Met Single submitter ⚠
- p.Thr487Ser Single submitter ⚠
- p.Thr499Ile Single submitter ⚠
- p.Trp107Ser Single submitter ⚠
- p.Trp176Cys Single submitter ⚠
- p.Tyr308Cys Single submitter ⚠
- p.Val1104Ile Single submitter ⚠
- p.Val32Gly Single submitter ⚠
- p.Val57Met Single submitter ⚠