PDE4B — 46 ClinVar variants
All ClinVar germline PDE4B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
4 Benign · 1 Likely benign · 41 Uncertain significance
Full PDE4B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDE4B p.Arg130Cys Uncertain significance Single submitter
- PDE4B p.Arg503Cys Uncertain significance Single submitter
- PDE4B p.Arg552His Uncertain significance Single submitter
- PDE4B p.Arg576Pro Uncertain significance Single submitter
- PDE4B p.Asn455Ser Uncertain significance Single submitter
- PDE4B p.Asn558Ile Uncertain significance Single submitter
- PDE4B p.Asp231Gly Uncertain significance Single submitter
- PDE4B p.Asp518Gly Uncertain significance Single submitter
- PDE4B p.Glu225Gly Uncertain significance Single submitter
- PDE4B p.Glu721Asp Uncertain significance Single submitter
- PDE4B p.Gly117Glu Uncertain significance Single submitter
- PDE4B p.His561Arg Uncertain significance Single submitter
- PDE4B p.Leu708Pro Uncertain significance Single submitter
- PDE4B p.Met496Ile Uncertain significance Single submitter
- PDE4B p.Met496Val Uncertain significance Single submitter
- PDE4B p.Pro713Thr Uncertain significance Single submitter
- PDE4B p.Ser384Pro Uncertain significance Single submitter
- PDE4B p.Ser704Gly Uncertain significance Single submitter
- PDE4B p.Thr222Met Uncertain significance Single submitter
- PDE4B p.Val205Ala Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- PDE4B p.Ser703Cys Benign Multiple submitters
- PDE4B p.Ala148Val Uncertain significance Single submitter
- PDE4B p.Arg581Cys Uncertain significance Single submitter
- PDE4B p.Asp162Asn Uncertain significance Single submitter
- PDE4B p.Asp376Glu Uncertain significance Single submitter
- PDE4B p.Asp528Asn Uncertain significance Single submitter
- PDE4B p.Asp717Tyr Uncertain significance Single submitter
- PDE4B p.Glu213Gly Uncertain significance Single submitter
- PDE4B p.Glu224Gln Uncertain significance Single submitter
- PDE4B p.Glu335Lys Uncertain significance Single submitter
- PDE4B p.Gly161Ser Uncertain significance Single submitter
- PDE4B p.Ile656Val Uncertain significance Single submitter
- PDE4B p.Leu682Val Uncertain significance Single submitter
- PDE4B p.Lys217Thr Uncertain significance Single submitter
- PDE4B p.Met368Ile Uncertain significance Single submitter
- PDE4B p.Ser150Leu Uncertain significance Single submitter
- PDE4B p.Ser654Asn Uncertain significance Single submitter
- PDE4B p.Ser689Phe Uncertain significance Single submitter
- PDE4B p.Thr323Lys Uncertain significance Single submitter
- PDE4B p.Thr535Met Uncertain significance Single submitter
- PDE4B p.Thr707Met Uncertain significance Single submitter
- PDE4B p.Val734Met Uncertain significance Single submitter
All PDE4B variants
Benign 4
- p.Arg596= Multiple submitters
- p.Leu642= Multiple submitters
- p.Ser703Cys Multiple submitters ⚠
- p.Asp447= Single submitter
Likely benign 1
- p.Ile352= Single submitter
Uncertain significance 41
- p.Ala148Val Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg503Cys Single submitter ⚠
- p.Arg552His Single submitter ⚠
- p.Arg576Pro Single submitter ⚠
- p.Arg581Cys Single submitter ⚠
- p.Asn455Ser Single submitter ⚠
- p.Asn558Ile Single submitter ⚠
- p.Asp162Asn Single submitter ⚠
- p.Asp231Gly Single submitter ⚠
- p.Asp376Glu Single submitter ⚠
- p.Asp518Gly Single submitter ⚠
- p.Asp528Asn Single submitter ⚠
- p.Asp717Tyr Single submitter ⚠
- p.Glu213Gly Single submitter ⚠
- p.Glu224Gln Single submitter ⚠
- p.Glu225Gly Single submitter ⚠
- p.Glu335Lys Single submitter ⚠
- p.Glu721Asp Single submitter ⚠
- p.Gly117Glu Single submitter ⚠
- p.Gly161Ser Single submitter ⚠
- p.His561Arg Single submitter ⚠
- p.Ile656Val Single submitter ⚠
- p.Leu682Val Single submitter ⚠
- p.Leu708Pro Single submitter ⚠
- p.Lys217Thr Single submitter ⚠
- p.Met368Ile Single submitter ⚠
- p.Met496Ile Single submitter ⚠
- p.Met496Val Single submitter ⚠
- p.Pro713Thr Single submitter ⚠
- p.Ser150Leu Single submitter ⚠
- p.Ser384Pro Single submitter ⚠
- p.Ser654Asn Single submitter ⚠
- p.Ser689Phe Single submitter ⚠
- p.Ser704Gly Single submitter ⚠
- p.Thr222Met Single submitter ⚠
- p.Thr323Lys Single submitter ⚠
- p.Thr535Met Single submitter ⚠
- p.Thr707Met Single submitter ⚠
- p.Val205Ala Single submitter ⚠
- p.Val734Met Single submitter ⚠