PDE4C — 82 ClinVar variants
All ClinVar germline PDE4C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Benign · 6 Likely benign · 75 Uncertain significance
Full PDE4C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDE4C p.Ala139Ser Uncertain significance Single submitter
- PDE4C p.Ala316Val Uncertain significance Single submitter
- PDE4C p.Ala351Thr Uncertain significance Single submitter
- PDE4C p.Ala354Ser Uncertain significance Single submitter
- PDE4C p.Ala431Val Uncertain significance Single submitter
- PDE4C p.Ala54Thr Uncertain significance Single submitter
- PDE4C p.Ala573Val Uncertain significance Single submitter
- PDE4C p.Arg134Trp Uncertain significance Single submitter
- PDE4C p.Arg18Cys Uncertain significance Single submitter
- PDE4C p.Arg34Leu Uncertain significance Single submitter
- PDE4C p.Arg41His Uncertain significance Single submitter
- PDE4C p.Arg64Gln Uncertain significance Single submitter
- PDE4C p.Arg81Gly Uncertain significance Single submitter
- PDE4C p.Asn410Lys Uncertain significance Single submitter
- PDE4C p.Asn427Lys Uncertain significance Single submitter
- PDE4C p.Asn615Asp Uncertain significance Single submitter
- PDE4C p.Asp363Asn Uncertain significance Single submitter
- PDE4C p.Asp443Asn Uncertain significance Single submitter
- PDE4C p.Asp622His Uncertain significance Single submitter
- PDE4C p.Asp676Asn Uncertain significance Single submitter
- PDE4C p.Gln366His Uncertain significance Single submitter
- PDE4C p.Gln527Arg Uncertain significance Single submitter
- PDE4C p.Gln565Glu Uncertain significance Single submitter
- PDE4C p.Gln603Arg Uncertain significance Single submitter
- PDE4C p.Gln603His Uncertain significance Single submitter
- PDE4C p.Glu11Gln Uncertain significance Single submitter
- PDE4C p.Glu642Gln Uncertain significance Single submitter
- PDE4C p.Glu660Gln Uncertain significance Single submitter
- PDE4C p.Glu8Ala Uncertain significance Single submitter
- PDE4C p.Gly347Arg Uncertain significance Single submitter
- PDE4C p.Gly547Val Uncertain significance Single submitter
- PDE4C p.Gly567Cys Uncertain significance Single submitter
- PDE4C p.Gly5Trp Uncertain significance Single submitter
- PDE4C p.Gly620Arg Uncertain significance Single submitter
- PDE4C p.Ile409Val Uncertain significance Single submitter
- PDE4C p.Ile569Thr Uncertain significance Single submitter
- PDE4C p.Leu140Pro Uncertain significance Single submitter
- PDE4C p.Leu377Arg Uncertain significance Single submitter
- PDE4C p.Leu61Val Uncertain significance Single submitter
- PDE4C p.Lys150Glu Uncertain significance Single submitter
- PDE4C p.Met418Thr Uncertain significance Single submitter
- PDE4C p.Phe331Cys Uncertain significance Single submitter
- PDE4C p.Pro164Leu Uncertain significance Single submitter
- PDE4C p.Pro165Ser Uncertain significance Single submitter
- PDE4C p.Pro29Ala Uncertain significance Single submitter
- PDE4C p.Pro29Leu Uncertain significance Single submitter
- PDE4C p.Pro575Leu Uncertain significance Single submitter
- PDE4C p.Ser159Phe Uncertain significance Single submitter
- PDE4C p.Ser24Ile Uncertain significance Single submitter
- PDE4C p.Ser404Pro Uncertain significance Single submitter
- PDE4C p.Thr659Ser Uncertain significance Single submitter
- PDE4C p.Val133Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- PDE4C p.Ala174Thr Uncertain significance Single submitter
- PDE4C p.Ala354Val Uncertain significance Single submitter
- PDE4C p.Ala389Val Uncertain significance Single submitter
- PDE4C p.Arg131Trp Uncertain significance Single submitter
- PDE4C p.Arg277Ser Uncertain significance Single submitter
- PDE4C p.Arg526His Uncertain significance Single submitter
- PDE4C p.Asn357Ser Uncertain significance Single submitter
- PDE4C p.Glu640Lys Uncertain significance Single submitter
- PDE4C p.Glu86Asp Uncertain significance Single submitter
- PDE4C p.His348Tyr Uncertain significance Single submitter
- PDE4C p.Ile461Val Uncertain significance Single submitter
- PDE4C p.Leu628Met Uncertain significance Single submitter
- PDE4C p.Pro607Thr Uncertain significance Single submitter
- PDE4C p.Thr368Met Uncertain significance Single submitter
- PDE4C p.Tyr525Cys Uncertain significance Single submitter
- PDE4C p.Val305Met Uncertain significance Single submitter
- PDE4C p.Val432Leu Uncertain significance Single submitter
All PDE4C variants
Benign 1
- p.Tyr96Cys Single submitter
Likely benign 6
- p.Ala477= Single submitter
- p.Arg618Trp Single submitter
- p.Gln287= Single submitter
- p.Leu675= Single submitter
- p.Pro153Ser Single submitter
- p.Val76Ile Single submitter
Uncertain significance 75
- p.Ala139Ser Single submitter ⚠
- p.Ala174Thr Single submitter ⚠
- p.Ala316Val Single submitter ⚠
- p.Ala351Thr Single submitter ⚠
- p.Ala354Ser Single submitter ⚠
- p.Ala354Val Single submitter ⚠
- p.Ala362Thr Single submitter
- p.Ala389Val Single submitter ⚠
- p.Ala431Val Single submitter ⚠
- p.Ala54Thr Single submitter ⚠
- p.Ala573Val Single submitter ⚠
- p.Ala588Val Single submitter
- p.Arg131Trp Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg277Ser Single submitter ⚠
- p.Arg34Leu Single submitter ⚠
- p.Arg41His Single submitter ⚠
- p.Arg526His Single submitter ⚠
- p.Arg64Gln Single submitter ⚠
- p.Arg81Gly Single submitter ⚠
- p.Arg91His Single submitter
- p.Asn357Ser Single submitter ⚠
- p.Asn410Lys Single submitter ⚠
- p.Asn427Lys Single submitter ⚠
- p.Asn615Asp Single submitter ⚠
- p.Asp363Asn Single submitter ⚠
- p.Asp443Asn Single submitter ⚠
- p.Asp622His Single submitter ⚠
- p.Asp676Asn Single submitter ⚠
- p.Gln366His Single submitter ⚠
- p.Gln527Arg Single submitter ⚠
- p.Gln565Glu Single submitter ⚠
- p.Gln603Arg Single submitter ⚠
- p.Gln603His Single submitter ⚠
- p.Glu11Gln Single submitter ⚠
- p.Glu640Lys Single submitter ⚠
- p.Glu642Gln Single submitter ⚠
- p.Glu660Gln Single submitter ⚠
- p.Glu86Asp Single submitter ⚠
- p.Glu8Ala Single submitter ⚠
- p.Gly347Arg Single submitter ⚠
- p.Gly492Ser Single submitter
- p.Gly547Val Single submitter ⚠
- p.Gly567Cys Single submitter ⚠
- p.Gly5Trp Single submitter ⚠
- p.Gly620Arg Single submitter ⚠
- p.His348Tyr Single submitter ⚠
- p.Ile409Val Single submitter ⚠
- p.Ile461Val Single submitter ⚠
- p.Ile569Thr Single submitter ⚠
- p.Ile569Val Single submitter
- p.Leu140Pro Single submitter ⚠
- p.Leu377Arg Single submitter ⚠
- p.Leu61Val Single submitter ⚠
- p.Leu628Met Single submitter ⚠
- p.Lys150Glu Single submitter ⚠
- p.Met418Thr Single submitter ⚠
- p.Met418Val Single submitter
- p.Phe331Cys Single submitter ⚠
- p.Pro164Leu Single submitter ⚠
- p.Pro165Ser Single submitter ⚠
- p.Pro29Ala Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Pro575Leu Single submitter ⚠
- p.Pro607Thr Single submitter ⚠
- p.Ser159Phe Single submitter ⚠
- p.Ser24Ile Single submitter ⚠
- p.Ser404Pro Single submitter ⚠
- p.Thr368Met Single submitter ⚠
- p.Thr659Ser Single submitter ⚠
- p.Tyr525Cys Single submitter ⚠
- p.Val133Ile Single submitter ⚠
- p.Val305Met Single submitter ⚠
- p.Val432Leu Single submitter ⚠