PDE7A — 43 ClinVar variants
All ClinVar germline PDE7A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
43 Uncertain significance
Full PDE7A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDE7A p.Ala466Asp Uncertain significance Single submitter
- PDE7A p.Ala467Pro Uncertain significance Single submitter
- PDE7A p.Ala467Thr Uncertain significance Single submitter
- PDE7A p.Arg195His Uncertain significance Single submitter
- PDE7A p.Arg348Gly Uncertain significance Single submitter
- PDE7A p.Arg435Ser Uncertain significance Single submitter
- PDE7A p.Arg91His Uncertain significance Single submitter
- PDE7A p.Asn153Ser Uncertain significance Single submitter
- PDE7A p.Asn268Lys Uncertain significance Single submitter
- PDE7A p.Asp157His Uncertain significance Single submitter
- PDE7A p.Asp465Val Uncertain significance Single submitter
- PDE7A p.Gln96Glu Uncertain significance Single submitter
- PDE7A p.His405Arg Uncertain significance Single submitter
- PDE7A p.His405Tyr Uncertain significance Single submitter
- PDE7A p.Ile201Val Uncertain significance Single submitter
- PDE7A p.Ile99Thr Uncertain significance Single submitter
- PDE7A p.Leu133Val Uncertain significance Single submitter
- PDE7A p.Leu319Val Uncertain significance Single submitter
- PDE7A p.Leu481Ser Uncertain significance Single submitter
- PDE7A p.Met310Val Uncertain significance Single submitter
- PDE7A p.Phe123Ile Uncertain significance Single submitter
- PDE7A p.Phe124Ser Uncertain significance Single submitter
- PDE7A p.Pro423Ala Uncertain significance Single submitter
- PDE7A p.Pro423Thr Uncertain significance Single submitter
- PDE7A p.Pro476Leu Uncertain significance Single submitter
- PDE7A p.Ser120Thr Uncertain significance Single submitter
- PDE7A p.Ser130Pro Uncertain significance Single submitter
- PDE7A p.Ser306Gly Uncertain significance Single submitter
- PDE7A p.Thr174Ile Uncertain significance Single submitter
- PDE7A p.Thr321Ser Uncertain significance Single submitter
- PDE7A p.Thr426Ala Uncertain significance Single submitter
- PDE7A p.Thr59Ser Uncertain significance Single submitter
- PDE7A p.Tyr394Asn Uncertain significance Single submitter
- PDE7A p.Val237Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- PDE7A p.Ala357Thr Uncertain significance Single submitter
- PDE7A p.Arg122Cys Uncertain significance Single submitter
- PDE7A p.Arg404Cys Uncertain significance Single submitter
- PDE7A p.Arg404His Uncertain significance Single submitter
- PDE7A p.His181Arg Uncertain significance Single submitter
- PDE7A p.Met224Ile Uncertain significance Single submitter
- PDE7A p.Pro210Ser Uncertain significance Single submitter
- PDE7A p.Pro400Leu Uncertain significance Single submitter
All PDE7A variants
Uncertain significance 43
- p.Ala357Thr Single submitter ⚠
- p.Ala466Asp Single submitter ⚠
- p.Ala467Pro Single submitter ⚠
- p.Ala467Thr Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg348Gly Single submitter ⚠
- p.Arg404Cys Single submitter ⚠
- p.Arg404His Single submitter ⚠
- p.Arg435Ser Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Asn153Ser Single submitter ⚠
- p.Asn268Lys Single submitter ⚠
- p.Asp157His Single submitter ⚠
- p.Asp465Val Single submitter ⚠
- p.Gln96Glu Single submitter ⚠
- p.His181Arg Single submitter ⚠
- p.His405Arg Single submitter ⚠
- p.His405Tyr Single submitter ⚠
- p.Ile201Val Single submitter ⚠
- p.Ile99Thr Single submitter ⚠
- p.Leu133Val Single submitter ⚠
- p.Leu319Val Single submitter ⚠
- p.Leu481Ser Single submitter ⚠
- p.Met224Ile Single submitter ⚠
- p.Met310Val Single submitter ⚠
- p.Phe123Ile Single submitter ⚠
- p.Phe124Ser Single submitter ⚠
- p.Pro210Ser Single submitter ⚠
- p.Pro400Leu Single submitter ⚠
- p.Pro423Ala Single submitter ⚠
- p.Pro423Thr Single submitter ⚠
- p.Pro476Leu Single submitter ⚠
- p.Pro86Ser Single submitter
- p.Ser120Thr Single submitter ⚠
- p.Ser130Pro Single submitter ⚠
- p.Ser306Gly Single submitter ⚠
- p.Thr174Ile Single submitter ⚠
- p.Thr321Ser Single submitter ⚠
- p.Thr426Ala Single submitter ⚠
- p.Thr59Ser Single submitter ⚠
- p.Tyr394Asn Single submitter ⚠
- p.Val237Leu Single submitter ⚠