PDE8A — 107 ClinVar variants
All ClinVar germline PDE8A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
5 Likely benign · 102 Uncertain significance
Full PDE8A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDE8A p.Ala366Val Uncertain significance Single submitter
- PDE8A p.Ala41Ser Uncertain significance Single submitter
- PDE8A p.Ala4Val Uncertain significance Single submitter
- PDE8A p.Ala630Val Uncertain significance Single submitter
- PDE8A p.Ala633Val Uncertain significance Single submitter
- PDE8A p.Ala667Thr Uncertain significance Single submitter
- PDE8A p.Arg163Cys Uncertain significance Single submitter
- PDE8A p.Arg235Leu Uncertain significance Single submitter
- PDE8A p.Arg368Cys Uncertain significance Single submitter
- PDE8A p.Arg368His Uncertain significance Single submitter
- PDE8A p.Arg417His Uncertain significance Single submitter
- PDE8A p.Arg487Trp Uncertain significance Single submitter
- PDE8A p.Arg524Pro Uncertain significance Single submitter
- PDE8A p.Arg709Lys Uncertain significance Single submitter
- PDE8A p.Arg822Gln Uncertain significance Single submitter
- PDE8A p.Asn398Ser Uncertain significance Single submitter
- PDE8A p.Asn557Ser Uncertain significance Single submitter
- PDE8A p.Asn605Ser Uncertain significance Single submitter
- PDE8A p.Asp437Val Uncertain significance Single submitter
- PDE8A p.Asp57Glu Uncertain significance Single submitter
- PDE8A p.Asp663Asn Uncertain significance Single submitter
- PDE8A p.Asp78Asn Uncertain significance Single submitter
- PDE8A p.Cys279Ser Uncertain significance Single submitter
- PDE8A p.Cys338Ser Uncertain significance Single submitter
- PDE8A p.Cys97Phe Uncertain significance Single submitter
- PDE8A p.Gln137His Uncertain significance Single submitter
- PDE8A p.Gln431His Uncertain significance Single submitter
- PDE8A p.Gln543Lys Uncertain significance Single submitter
- PDE8A p.Gln635Arg Uncertain significance Single submitter
- PDE8A p.Gln735His Uncertain significance Single submitter
- PDE8A p.Glu337Lys Uncertain significance Single submitter
- PDE8A p.Glu495Asp Uncertain significance Single submitter
- PDE8A p.Glu52Lys Uncertain significance Single submitter
- PDE8A p.Gly257Arg Uncertain significance Single submitter
- PDE8A p.Gly261Arg Uncertain significance Single submitter
- PDE8A p.Gly47Asp Uncertain significance Single submitter
- PDE8A p.Gly60Asp Uncertain significance Single submitter
- PDE8A p.His344Arg Uncertain significance Single submitter
- PDE8A p.His550Asp Uncertain significance Single submitter
- PDE8A p.His76Arg Uncertain significance Single submitter
- PDE8A p.His8Arg Uncertain significance Single submitter
- PDE8A p.Ile158Val Uncertain significance Single submitter
- PDE8A p.Ile335Met Uncertain significance Single submitter
- PDE8A p.Ile782Thr Uncertain significance Single submitter
- PDE8A p.Leu152Pro Uncertain significance Single submitter
- PDE8A p.Leu26Arg Uncertain significance Single submitter
- PDE8A p.Leu734Gln Uncertain significance Single submitter
- PDE8A p.Leu824Phe Uncertain significance Single submitter
- PDE8A p.Lys61Gln Uncertain significance Single submitter
- PDE8A p.Met381Thr Uncertain significance Single submitter
- PDE8A p.Met819Thr Uncertain significance Single submitter
- PDE8A p.Pro21Leu Uncertain significance Single submitter
- PDE8A p.Pro21Ser Uncertain significance Single submitter
- PDE8A p.Pro43Leu Uncertain significance Single submitter
- PDE8A p.Pro485Thr Uncertain significance Single submitter
- PDE8A p.Pro513Arg Uncertain significance Single submitter
- PDE8A p.Pro583Arg Uncertain significance Single submitter
- PDE8A p.Pro583Ser Uncertain significance Single submitter
- PDE8A p.Pro5Arg Uncertain significance Single submitter
- PDE8A p.Ser27Leu Uncertain significance Single submitter
- PDE8A p.Ser336Phe Uncertain significance Single submitter
- PDE8A p.Ser373Phe Uncertain significance Single submitter
- PDE8A p.Ser373Thr Uncertain significance Single submitter
- PDE8A p.Ser379Pro Uncertain significance Single submitter
- PDE8A p.Ser552Ala Uncertain significance Single submitter
- PDE8A p.Thr219Ser Uncertain significance Single submitter
- PDE8A p.Thr345Ala Uncertain significance Single submitter
- PDE8A p.Thr465Ala Uncertain significance Single submitter
- PDE8A p.Trp541Cys Uncertain significance Single submitter
- PDE8A p.Tyr654Cys Uncertain significance Single submitter
- PDE8A p.Val109Ala Uncertain significance Single submitter
- PDE8A p.Val325Ala Uncertain significance Single submitter
- PDE8A p.Val325Leu Uncertain significance Single submitter
- PDE8A p.Val362Ile Uncertain significance Single submitter
- PDE8A p.Val362Leu Uncertain significance Single submitter
- PDE8A p.Val587Ile Uncertain significance Single submitter
- PDE8A p.Val68Met Uncertain significance Single submitter
- PDE8A p.Val763Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- PDE8A p.Arg383Gln Uncertain significance Single submitter
- PDE8A p.Arg524Cys Uncertain significance Single submitter
- PDE8A p.Arg714Gln Uncertain significance Single submitter
- PDE8A p.Asp443His Uncertain significance Single submitter
- PDE8A p.Asp783Asn Uncertain significance Single submitter
- PDE8A p.Glu405Gly Uncertain significance Single submitter
- PDE8A p.Ile389Phe Uncertain significance Single submitter
- PDE8A p.Met387Ile Uncertain significance Single submitter
- PDE8A p.Pro174Arg Uncertain significance Single submitter
- PDE8A p.Pro765Leu Uncertain significance Single submitter
- PDE8A p.Ser359Leu Uncertain significance Single submitter
- PDE8A p.Ser406Arg Uncertain significance Single submitter
- PDE8A p.Ser551Phe Uncertain significance Single submitter
- PDE8A p.Ser6Arg Uncertain significance Single submitter
- PDE8A p.Thr537Met Uncertain significance Single submitter
- PDE8A p.Tyr319Cys Uncertain significance Single submitter
- PDE8A p.Tyr570Cys Uncertain significance Single submitter
All PDE8A variants
Likely benign 5
- p.Arg235His Single submitter
- p.Asp482His Single submitter
- p.Pro43Ser Single submitter
- p.Ser336Pro Single submitter
- p.Val159Ile Single submitter
Uncertain significance 102
- p.Ala366Val Single submitter ⚠
- p.Ala41Ser Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Ala630Val Single submitter ⚠
- p.Ala633Val Single submitter ⚠
- p.Ala667Thr Single submitter ⚠
- p.Ala792Gly Single submitter
- p.Arg163Cys Single submitter ⚠
- p.Arg235Leu Single submitter ⚠
- p.Arg368Cys Single submitter ⚠
- p.Arg368His Single submitter ⚠
- p.Arg377Gln Single submitter
- p.Arg383Gln Single submitter ⚠
- p.Arg417His Single submitter ⚠
- p.Arg487Trp Single submitter ⚠
- p.Arg524Cys Single submitter ⚠
- p.Arg524Pro Single submitter ⚠
- p.Arg709Lys Single submitter ⚠
- p.Arg714Gln Single submitter ⚠
- p.Arg822Gln Single submitter ⚠
- p.Asn398Ser Single submitter ⚠
- p.Asn557Ser Single submitter ⚠
- p.Asn605Ser Single submitter ⚠
- p.Asp437Val Single submitter ⚠
- p.Asp443His Single submitter ⚠
- p.Asp57Glu Single submitter ⚠
- p.Asp663Asn Single submitter ⚠
- p.Asp783Asn Single submitter ⚠
- p.Asp78Asn Single submitter ⚠
- p.Asp817Glu Single submitter
- p.Cys279Ser Single submitter ⚠
- p.Cys338Ser Single submitter ⚠
- p.Cys97Phe Single submitter ⚠
- p.Gln137His Single submitter ⚠
- p.Gln431His Single submitter ⚠
- p.Gln543Lys Single submitter ⚠
- p.Gln635Arg Single submitter ⚠
- p.Gln735His Single submitter ⚠
- p.Glu337Lys Single submitter ⚠
- p.Glu405Gly Single submitter ⚠
- p.Glu495Asp Single submitter ⚠
- p.Glu52Lys Single submitter ⚠
- p.Glu535Lys Single submitter
- p.Gly257Arg Single submitter ⚠
- p.Gly261Arg Single submitter ⚠
- p.Gly47Asp Single submitter ⚠
- p.Gly60Asp Single submitter ⚠
- p.His344Arg Single submitter ⚠
- p.His550Asp Single submitter ⚠
- p.His76Arg Single submitter ⚠
- p.His8Arg Single submitter ⚠
- p.Ile158Val Single submitter ⚠
- p.Ile335Met Single submitter ⚠
- p.Ile389Phe Single submitter ⚠
- p.Ile782Thr Single submitter ⚠
- p.Leu152Pro Single submitter ⚠
- p.Leu26Arg Single submitter ⚠
- p.Leu734Gln Single submitter ⚠
- p.Leu824Phe Single submitter ⚠
- p.Lys578Thr Single submitter
- p.Lys61Gln Single submitter ⚠
- p.Met381Thr Single submitter ⚠
- p.Met387Ile Single submitter ⚠
- p.Met819Thr Single submitter ⚠
- p.Pro174Arg Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro21Ser Single submitter ⚠
- p.Pro43Leu Single submitter ⚠
- p.Pro485Thr Single submitter ⚠
- p.Pro513Arg Single submitter ⚠
- p.Pro554Leu Single submitter
- p.Pro583Arg Single submitter ⚠
- p.Pro583Ser Single submitter ⚠
- p.Pro5Arg Single submitter ⚠
- p.Pro765Leu Single submitter ⚠
- p.Ser27Leu Single submitter ⚠
- p.Ser336Phe Single submitter ⚠
- p.Ser359Leu Single submitter ⚠
- p.Ser373Phe Single submitter ⚠
- p.Ser373Thr Single submitter ⚠
- p.Ser379Pro Single submitter ⚠
- p.Ser406Arg Single submitter ⚠
- p.Ser551Phe Single submitter ⚠
- p.Ser552Ala Single submitter ⚠
- p.Ser6Arg Single submitter ⚠
- p.Thr219Ser Single submitter ⚠
- p.Thr345Ala Single submitter ⚠
- p.Thr388Ser Single submitter
- p.Thr465Ala Single submitter ⚠
- p.Thr537Met Single submitter ⚠
- p.Trp541Cys Single submitter ⚠
- p.Tyr319Cys Single submitter ⚠
- p.Tyr570Cys Single submitter ⚠
- p.Tyr654Cys Single submitter ⚠
- p.Val109Ala Single submitter ⚠
- p.Val325Ala Single submitter ⚠
- p.Val325Leu Single submitter ⚠
- p.Val362Ile Single submitter ⚠
- p.Val362Leu Single submitter ⚠
- p.Val587Ile Single submitter ⚠
- p.Val68Met Single submitter ⚠
- p.Val763Leu Single submitter ⚠