PDIA4 — 88 ClinVar variants
All ClinVar germline PDIA4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
1 Benign · 6 Likely benign · 81 Uncertain significance
Full PDIA4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDIA4 p.Ala20Gly Uncertain significance Single submitter
- PDIA4 p.Ala220Thr Uncertain significance Single submitter
- PDIA4 p.Ala237Thr Uncertain significance Single submitter
- PDIA4 p.Ala384Thr Uncertain significance Single submitter
- PDIA4 p.Ala442Val Uncertain significance Single submitter
- PDIA4 p.Ala569Thr Uncertain significance Single submitter
- PDIA4 p.Ala70Val Uncertain significance Single submitter
- PDIA4 p.Arg226His Uncertain significance Single submitter
- PDIA4 p.Arg259Cys Uncertain significance Single submitter
- PDIA4 p.Arg270Gln Uncertain significance Single submitter
- PDIA4 p.Arg400His Uncertain significance Single submitter
- PDIA4 p.Arg408Cys Uncertain significance Single submitter
- PDIA4 p.Arg435Gln Uncertain significance Single submitter
- PDIA4 p.Arg622Gly Uncertain significance Single submitter
- PDIA4 p.Asn588Thr Uncertain significance Single submitter
- PDIA4 p.Asp248Gly Uncertain significance Single submitter
- PDIA4 p.Asp405Asn Uncertain significance Single submitter
- PDIA4 p.Asp457Asn Uncertain significance Single submitter
- PDIA4 p.Asp49Val Uncertain significance Single submitter
- PDIA4 p.Asp55Tyr Uncertain significance Single submitter
- PDIA4 p.Asp610Asn Uncertain significance Single submitter
- PDIA4 p.Gln169His Uncertain significance Single submitter
- PDIA4 p.Gln96Arg Uncertain significance Single submitter
- PDIA4 p.Glu281Lys Uncertain significance Single submitter
- PDIA4 p.Glu39Asp Uncertain significance Single submitter
- PDIA4 p.Glu492Gly Uncertain significance Single submitter
- PDIA4 p.Glu500Lys Uncertain significance Single submitter
- PDIA4 p.Gly310Arg Uncertain significance Single submitter
- PDIA4 p.Gly525Arg Uncertain significance Single submitter
- PDIA4 p.Gly532Glu Uncertain significance Single submitter
- PDIA4 p.Gly574Ser Uncertain significance Single submitter
- PDIA4 p.His338Arg Uncertain significance Single submitter
- PDIA4 p.His93Arg Uncertain significance Single submitter
- PDIA4 p.Ile538Val Uncertain significance Single submitter
- PDIA4 p.Ile603Val Uncertain significance Single submitter
- PDIA4 p.Leu180Phe Uncertain significance Single submitter
- PDIA4 p.Leu467Phe Uncertain significance Single submitter
- PDIA4 p.Leu65Trp Uncertain significance Single submitter
- PDIA4 p.Leu9Phe Uncertain significance Single submitter
- PDIA4 p.Lys210Arg Uncertain significance Single submitter
- PDIA4 p.Lys221Arg Uncertain significance Single submitter
- PDIA4 p.Lys313Asn Uncertain significance Single submitter
- PDIA4 p.Lys443Arg Uncertain significance Single submitter
- PDIA4 p.Lys485Arg Uncertain significance Single submitter
- PDIA4 p.Lys528Arg Uncertain significance Single submitter
- PDIA4 p.Lys611Thr Uncertain significance Single submitter
- PDIA4 p.Phe299Leu Uncertain significance Single submitter
- PDIA4 p.Pro553Ser Uncertain significance Single submitter
- PDIA4 p.Pro89Ala Uncertain significance Single submitter
- PDIA4 p.Ser316Arg Uncertain significance Single submitter
- PDIA4 p.Ser341Gly Uncertain significance Single submitter
- PDIA4 p.Ser436Arg Uncertain significance Single submitter
- PDIA4 p.Thr139Ile Uncertain significance Single submitter
- PDIA4 p.Thr179Met Uncertain significance Single submitter
- PDIA4 p.Thr183Ile Uncertain significance Single submitter
- PDIA4 p.Tyr595Cys Uncertain significance Single submitter
- PDIA4 p.Val181Ala Uncertain significance Single submitter
- PDIA4 p.Val181Met Uncertain significance Single submitter
- PDIA4 p.Val350Leu Uncertain significance Single submitter
- PDIA4 p.Val417Ile Uncertain significance Single submitter
- PDIA4 p.Val462Met Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- PDIA4 p.Ala129Val Uncertain significance Single submitter
- PDIA4 p.Ala581Thr Uncertain significance Single submitter
- PDIA4 p.Ala606Thr Uncertain significance Single submitter
- PDIA4 p.Asn523Ser Uncertain significance Single submitter
- PDIA4 p.Asp305Gly Uncertain significance Single submitter
- PDIA4 p.Asp593Tyr Uncertain significance Single submitter
- PDIA4 p.Glu166Gly Uncertain significance Single submitter
- PDIA4 p.Gly251Ser Uncertain significance Single submitter
- PDIA4 p.Gly284Arg Uncertain significance Single submitter
- PDIA4 p.Ile120Met Uncertain significance Single submitter
- PDIA4 p.Ile196Thr Uncertain significance Single submitter
- PDIA4 p.Met488Val Uncertain significance Single submitter
- PDIA4 p.Phe423Leu Uncertain significance Single submitter
- PDIA4 p.Pro285Arg Uncertain significance Single submitter
- PDIA4 p.Pro446His Uncertain significance Single submitter
- PDIA4 p.Thr241Ile Uncertain significance Single submitter
- PDIA4 p.Val546Ile Uncertain significance Single submitter
- PDIA4 p.Val564Met Uncertain significance Single submitter
- PDIA4 p.Val590Asp Uncertain significance Single submitter
All PDIA4 variants
Benign 1
- p.Thr238= Single submitter
Likely benign 6
- p.Thr241Ala Multiple submitters
- p.Ala393Thr Single submitter
- p.Asn566Ser Single submitter
- p.Asp171Asn Single submitter
- p.Val376Ile Single submitter
- p.Gln17Leu No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 81
- p.Ala129Val Single submitter ⚠
- p.Ala20Gly Single submitter ⚠
- p.Ala220Thr Single submitter ⚠
- p.Ala237Thr Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Ala442Val Single submitter ⚠
- p.Ala569Thr Single submitter ⚠
- p.Ala581Thr Single submitter ⚠
- p.Ala585Thr Single submitter
- p.Ala606Thr Single submitter ⚠
- p.Ala70Val Single submitter ⚠
- p.Arg226His Single submitter ⚠
- p.Arg259Cys Single submitter ⚠
- p.Arg270Gln Single submitter ⚠
- p.Arg400His Single submitter ⚠
- p.Arg408Cys Single submitter ⚠
- p.Arg435Gln Single submitter ⚠
- p.Arg622Gly Single submitter ⚠
- p.Asn523Ser Single submitter ⚠
- p.Asn588Thr Single submitter ⚠
- p.Asp248Gly Single submitter ⚠
- p.Asp305Gly Single submitter ⚠
- p.Asp405Asn Single submitter ⚠
- p.Asp457Asn Single submitter ⚠
- p.Asp49Val Single submitter ⚠
- p.Asp55Tyr Single submitter ⚠
- p.Asp593Tyr Single submitter ⚠
- p.Asp610Asn Single submitter ⚠
- p.Gln169His Single submitter ⚠
- p.Gln96Arg Single submitter ⚠
- p.Glu166Gly Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Glu39Asp Single submitter ⚠
- p.Glu492Gly Single submitter ⚠
- p.Glu500Lys Single submitter ⚠
- p.Gly251Ser Single submitter ⚠
- p.Gly284Arg Single submitter ⚠
- p.Gly310Arg Single submitter ⚠
- p.Gly525Arg Single submitter ⚠
- p.Gly532Glu Single submitter ⚠
- p.Gly574Ser Single submitter ⚠
- p.His338Arg Single submitter ⚠
- p.His93Arg Single submitter ⚠
- p.Ile120Met Single submitter ⚠
- p.Ile196Thr Single submitter ⚠
- p.Ile538Val Single submitter ⚠
- p.Ile603Val Single submitter ⚠
- p.Leu180Phe Single submitter ⚠
- p.Leu467Phe Single submitter ⚠
- p.Leu65Trp Single submitter ⚠
- p.Leu9Phe Single submitter ⚠
- p.Lys210Arg Single submitter ⚠
- p.Lys221Arg Single submitter ⚠
- p.Lys313Asn Single submitter ⚠
- p.Lys443Arg Single submitter ⚠
- p.Lys485Arg Single submitter ⚠
- p.Lys528Arg Single submitter ⚠
- p.Lys611Thr Single submitter ⚠
- p.Met488Val Single submitter ⚠
- p.Phe299Leu Single submitter ⚠
- p.Phe423Leu Single submitter ⚠
- p.Pro285Arg Single submitter ⚠
- p.Pro446His Single submitter ⚠
- p.Pro553Ser Single submitter ⚠
- p.Pro89Ala Single submitter ⚠
- p.Ser316Arg Single submitter ⚠
- p.Ser341Gly Single submitter ⚠
- p.Ser436Arg Single submitter ⚠
- p.Thr139Ile Single submitter ⚠
- p.Thr179Met Single submitter ⚠
- p.Thr183Ile Single submitter ⚠
- p.Thr241Ile Single submitter ⚠
- p.Tyr595Cys Single submitter ⚠
- p.Val181Ala Single submitter ⚠
- p.Val181Met Single submitter ⚠
- p.Val350Leu Single submitter ⚠
- p.Val417Ile Single submitter ⚠
- p.Val462Met Single submitter ⚠
- p.Val546Ile Single submitter ⚠
- p.Val564Met Single submitter ⚠
- p.Val590Asp Single submitter ⚠