PDK4 — 60 ClinVar variants
All ClinVar germline PDK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Benign · 2 Likely benign · 57 Uncertain significance
Full PDK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDK4 p.Ala66Thr Uncertain significance Single submitter
- PDK4 p.Arg161Gln Uncertain significance Single submitter
- PDK4 p.Arg166His Uncertain significance Single submitter
- PDK4 p.Arg323Gln Uncertain significance Single submitter
- PDK4 p.Arg323Leu Uncertain significance Single submitter
- PDK4 p.Arg5His Uncertain significance Single submitter
- PDK4 p.Asn174Lys Uncertain significance Single submitter
- PDK4 p.Asn324His Uncertain significance Single submitter
- PDK4 p.Asn404Lys Uncertain significance Single submitter
- PDK4 p.Asp236Glu Uncertain significance Single submitter
- PDK4 p.Asp347Glu Uncertain significance Single submitter
- PDK4 p.Gln110Pro Uncertain significance Single submitter
- PDK4 p.Gln136His Uncertain significance Single submitter
- PDK4 p.Glu25Ala Uncertain significance Single submitter
- PDK4 p.Glu60Gln Uncertain significance Single submitter
- PDK4 p.Gly18Asp Uncertain significance Single submitter
- PDK4 p.Gly333Ser Uncertain significance Single submitter
- PDK4 p.Gly355Ala Uncertain significance Single submitter
- PDK4 p.Ile121Met Uncertain significance Single submitter
- PDK4 p.Ile191Thr Uncertain significance Single submitter
- PDK4 p.Ile68Val Uncertain significance Single submitter
- PDK4 p.Leu178Ile Uncertain significance Single submitter
- PDK4 p.Leu287Ile Uncertain significance Single submitter
- PDK4 p.Lys284Asn Uncertain significance Single submitter
- PDK4 p.Lys2Gln Uncertain significance Single submitter
- PDK4 p.Met411Thr Uncertain significance Single submitter
- PDK4 p.Phe158Leu Uncertain significance Single submitter
- PDK4 p.Phe234Val Uncertain significance Single submitter
- PDK4 p.Phe330Cys Uncertain significance Single submitter
- PDK4 p.Phe6Leu Uncertain significance Single submitter
- PDK4 p.Pro21His Uncertain significance Single submitter
- PDK4 p.Ser10Arg Uncertain significance Single submitter
- PDK4 p.Ser28Trp Uncertain significance Single submitter
- PDK4 p.Ser95Asn Uncertain significance Single submitter
- PDK4 p.Thr316Arg Uncertain significance Single submitter
- PDK4 p.Thr316Met Uncertain significance Single submitter
- PDK4 p.Thr77Ile Uncertain significance Single submitter
- PDK4 p.Tyr309Cys Uncertain significance Single submitter
- PDK4 p.Val117Glu Uncertain significance Single submitter
- PDK4 p.Val117Ile Uncertain significance Single submitter
- PDK4 p.Val230Met Uncertain significance Single submitter
- PDK4 p.Val377Ile Uncertain significance Single submitter
-
PDK4 p.Val20Gly
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 11
The independent predictors disagree with each other — read with care.
- PDK4 p.Met134Val Benign Multiple submitters
- PDK4 p.Arg323Trp Uncertain significance Single submitter
- PDK4 p.Cys210Arg Uncertain significance Single submitter
- PDK4 p.Gln217Lys Uncertain significance Single submitter
- PDK4 p.Glu140Asp Uncertain significance Single submitter
- PDK4 p.His240Leu Uncertain significance Single submitter
- PDK4 p.His240Tyr Uncertain significance Single submitter
- PDK4 p.Pro275Ser Uncertain significance Single submitter
- PDK4 p.Ser211Leu Uncertain significance Single submitter
- PDK4 p.Ser221Pro Uncertain significance Single submitter
- PDK4 p.Ser31Arg Uncertain significance Single submitter
All PDK4 variants
Benign 1
- p.Met134Val Multiple submitters ⚠
Likely benign 2
- c.870+10C>G Single submitter
- p.Met411Val Single submitter
Uncertain significance 57
- p.Ala66Thr Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg323Leu Single submitter ⚠
- p.Arg323Trp Single submitter ⚠
- p.Arg58Ter Single submitter
- p.Arg5His Single submitter ⚠
- p.Asn174Lys Single submitter ⚠
- p.Asn324His Single submitter ⚠
- p.Asn404Lys Single submitter ⚠
- p.Asp236Glu Single submitter ⚠
- p.Asp347Glu Single submitter ⚠
- p.Cys210Arg Single submitter ⚠
- p.Gln110Pro Single submitter ⚠
- p.Gln136His Single submitter ⚠
- p.Gln217Lys Single submitter ⚠
- p.Glu140Asp Single submitter ⚠
- p.Glu25Ala Single submitter ⚠
- p.Glu60Gln Single submitter ⚠
- p.Gly18Asp Single submitter ⚠
- p.Gly296Ser Single submitter
- p.Gly333Ser Single submitter ⚠
- p.Gly355Ala Single submitter ⚠
- p.His240Leu Single submitter ⚠
- p.His240Tyr Single submitter ⚠
- p.Ile121Met Single submitter ⚠
- p.Ile191Thr Single submitter ⚠
- p.Ile68Val Single submitter ⚠
- p.Leu178Ile Single submitter ⚠
- p.Leu287Ile Single submitter ⚠
- p.Leu300Pro Single submitter
- p.Lys284Asn Single submitter ⚠
- p.Lys2Gln Single submitter ⚠
- p.Met411Thr Single submitter ⚠
- p.Phe158Leu Single submitter ⚠
- p.Phe234Val Single submitter ⚠
- p.Phe330Cys Single submitter ⚠
- p.Phe6Leu Single submitter ⚠
- p.Pro132Ser Single submitter
- p.Pro21His Single submitter ⚠
- p.Pro275Ser Single submitter ⚠
- p.Ser10Arg Single submitter ⚠
- p.Ser211Leu Single submitter ⚠
- p.Ser221Pro Single submitter ⚠
- p.Ser28Trp Single submitter ⚠
- p.Ser31Arg Single submitter ⚠
- p.Ser95Asn Single submitter ⚠
- p.Thr316Arg Single submitter ⚠
- p.Thr316Met Single submitter ⚠
- p.Thr77Ile Single submitter ⚠
- p.Tyr309Cys Single submitter ⚠
- p.Val117Glu Single submitter ⚠
- p.Val117Ile Single submitter ⚠
- p.Val230Met Single submitter ⚠
- p.Val377Ile Single submitter ⚠
- p.Val20Gly No assertion criteria prostate cancer ⚠