PDLIM5 — 86 ClinVar variants
All ClinVar germline PDLIM5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
2 Benign · 6 Likely benign · 78 Uncertain significance
Full PDLIM5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDLIM5 p.Ala155Val Uncertain significance Single submitter
- PDLIM5 p.Ala187Val Uncertain significance Single submitter
- PDLIM5 p.Ala196Thr Uncertain significance Single submitter
- PDLIM5 p.Ala200Glu Uncertain significance Single submitter
- PDLIM5 p.Ala317Gly Uncertain significance Single submitter
- PDLIM5 p.Ala476Val Uncertain significance Single submitter
- PDLIM5 p.Ala66Thr Uncertain significance Single submitter
- PDLIM5 p.Ala87Val Uncertain significance Single submitter
- PDLIM5 p.Arg130Gln Uncertain significance Single submitter
- PDLIM5 p.Arg130Leu Uncertain significance Single submitter
- PDLIM5 p.Arg205Trp Uncertain significance Single submitter
- PDLIM5 p.Arg246Cys Uncertain significance Single submitter
- PDLIM5 p.Arg324Gln Uncertain significance Single submitter
- PDLIM5 p.Arg337Ser Uncertain significance Single submitter
- PDLIM5 p.Arg484Lys Uncertain significance Single submitter
- PDLIM5 p.Asn184Ser Uncertain significance Single submitter
- PDLIM5 p.Asn378Ser Uncertain significance Single submitter
- PDLIM5 p.Asn424Ser Uncertain significance Single submitter
- PDLIM5 p.Asn445Ser Uncertain significance Single submitter
- PDLIM5 p.Asn595Lys Uncertain significance Single submitter
- PDLIM5 p.Asp35Asn Uncertain significance Single submitter
- PDLIM5 p.Asp48Asn Uncertain significance Single submitter
- PDLIM5 p.Asp48His Uncertain significance Single submitter
- PDLIM5 p.Glu215Lys Uncertain significance Single submitter
- PDLIM5 p.Glu91Ala Uncertain significance Single submitter
- PDLIM5 p.Gly21Ser Uncertain significance Single submitter
- PDLIM5 p.Gly75Ser Uncertain significance Single submitter
- PDLIM5 p.His256Arg Uncertain significance Single submitter
- PDLIM5 p.His422Arg Uncertain significance Single submitter
- PDLIM5 p.Ile243Thr Uncertain significance Single submitter
- PDLIM5 p.Ile376Val Uncertain significance Single submitter
- PDLIM5 p.Ile537Leu Uncertain significance Single submitter
- PDLIM5 p.Ile537Val Uncertain significance Single submitter
- PDLIM5 p.Leu220Ile Uncertain significance Single submitter
- PDLIM5 p.Lys38Asn Uncertain significance Single submitter
- PDLIM5 p.Lys450Arg Uncertain significance Single submitter
- PDLIM5 p.Met123Ile Uncertain significance Single submitter
- PDLIM5 p.Met419Leu Uncertain significance Single submitter
- PDLIM5 p.Pro152Leu Uncertain significance Single submitter
- PDLIM5 p.Pro254Leu Uncertain significance Single submitter
- PDLIM5 p.Pro273Thr Uncertain significance Single submitter
- PDLIM5 p.Pro314Leu Uncertain significance Single submitter
- PDLIM5 p.Pro418Leu Uncertain significance Single submitter
- PDLIM5 p.Pro441Arg Uncertain significance Single submitter
- PDLIM5 p.Pro88Ser Uncertain significance Single submitter
- PDLIM5 p.Pro90Ser Uncertain significance Single submitter
- PDLIM5 p.Ser119Phe Uncertain significance Single submitter
- PDLIM5 p.Ser136Ala Uncertain significance Single submitter
- PDLIM5 p.Ser147Leu Uncertain significance Single submitter
- PDLIM5 p.Ser148Cys Uncertain significance Single submitter
- PDLIM5 p.Ser164Leu Uncertain significance Single submitter
- PDLIM5 p.Ser325Thr Uncertain significance Single submitter
- PDLIM5 p.Ser360Ala Uncertain significance Single submitter
- PDLIM5 p.Thr156Ser Uncertain significance Single submitter
- PDLIM5 p.Thr208Ala Uncertain significance Single submitter
- PDLIM5 p.Thr452Ala Uncertain significance Single submitter
- PDLIM5 p.Tyr251Cys Uncertain significance Single submitter
- PDLIM5 p.Val166Met Uncertain significance Single submitter
- PDLIM5 p.Val169Ala Uncertain significance Single submitter
- PDLIM5 p.Val169Ile Uncertain significance Single submitter
- PDLIM5 p.Val44Ile Uncertain significance Single submitter
- PDLIM5 p.Val490Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- PDLIM5 p.Tyr557Cys Likely benign Multiple submitters
- PDLIM5 p.Ala493Val Uncertain significance Single submitter
- PDLIM5 p.Arg272His Uncertain significance Single submitter
- PDLIM5 p.Arg284Gln Uncertain significance Single submitter
- PDLIM5 p.Arg365Trp Uncertain significance Single submitter
- PDLIM5 p.Arg513Gln Uncertain significance Single submitter
- PDLIM5 p.Cys570Tyr Uncertain significance Single submitter
- PDLIM5 p.Gly36Val Uncertain significance Single submitter
- PDLIM5 p.Gly37Ser Uncertain significance Single submitter
- PDLIM5 p.His539Gln Uncertain significance Single submitter
- PDLIM5 p.Leu533Val Uncertain significance Single submitter
- PDLIM5 p.Lys241Ile Uncertain significance Single submitter
- PDLIM5 p.Met419Thr Uncertain significance Single submitter
- PDLIM5 p.Ser572Gly Uncertain significance Single submitter
All PDLIM5 variants
Likely benign 6
- p.Tyr557Cys Multiple submitters ⚠
- c.96+871G>A Single submitter
- p.Glu409= Single submitter
- p.Leu173Pro Single submitter
- p.Thr334Ala Single submitter
- p.Val357Ile Single submitter
Uncertain significance 78
- p.Ala155Val Single submitter ⚠
- p.Ala187Val Single submitter ⚠
- p.Ala196Thr Single submitter ⚠
- p.Ala200Glu Single submitter ⚠
- p.Ala317Gly Single submitter ⚠
- p.Ala476Val Single submitter ⚠
- p.Ala493Val Single submitter ⚠
- p.Ala66Thr Single submitter ⚠
- p.Ala87Val Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg130Leu Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg246Cys Single submitter ⚠
- p.Arg272His Single submitter ⚠
- p.Arg284Gln Single submitter ⚠
- p.Arg324Gln Single submitter ⚠
- p.Arg337Ser Single submitter ⚠
- p.Arg365Trp Single submitter ⚠
- p.Arg484Lys Single submitter ⚠
- p.Arg513Gln Single submitter ⚠
- p.Asn184Ser Single submitter ⚠
- p.Asn378Ser Single submitter ⚠
- p.Asn424Ser Single submitter ⚠
- p.Asn445Ser Single submitter ⚠
- p.Asn595Lys Single submitter ⚠
- p.Asp35Asn Single submitter ⚠
- p.Asp48Asn Single submitter ⚠
- p.Asp48His Single submitter ⚠
- p.Cys570Tyr Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu91Ala Single submitter ⚠
- p.Gly21Ser Single submitter ⚠
- p.Gly36Val Single submitter ⚠
- p.Gly37Ser Single submitter ⚠
- p.Gly75Ser Single submitter ⚠
- p.His256Arg Single submitter ⚠
- p.His422Arg Single submitter ⚠
- p.His539Gln Single submitter ⚠
- p.Ile243Thr Single submitter ⚠
- p.Ile376Val Single submitter ⚠
- p.Ile537Leu Single submitter ⚠
- p.Ile537Val Single submitter ⚠
- p.Leu220Ile Single submitter ⚠
- p.Leu533Val Single submitter ⚠
- p.Lys241Ile Single submitter ⚠
- p.Lys38Asn Single submitter ⚠
- p.Lys450Arg Single submitter ⚠
- p.Met123Ile Single submitter ⚠
- p.Met419Leu Single submitter ⚠
- p.Met419Thr Single submitter ⚠
- p.Met453Val Single submitter
- p.Pro131Thr Single submitter
- p.Pro152Leu Single submitter ⚠
- p.Pro254Leu Single submitter ⚠
- p.Pro273Thr Single submitter ⚠
- p.Pro314Leu Single submitter ⚠
- p.Pro418Leu Single submitter ⚠
- p.Pro441Arg Single submitter ⚠
- p.Pro88Ser Single submitter ⚠
- p.Pro90Ser Single submitter ⚠
- p.Ser119Phe Single submitter ⚠
- p.Ser136Ala Single submitter ⚠
- p.Ser147Leu Single submitter ⚠
- p.Ser148Cys Single submitter ⚠
- p.Ser164Leu Single submitter ⚠
- p.Ser325Thr Single submitter ⚠
- p.Ser360Ala Single submitter ⚠
- p.Ser572Gly Single submitter ⚠
- p.Thr156Ser Single submitter ⚠
- p.Thr208Ala Single submitter ⚠
- p.Thr268Ala Single submitter
- p.Thr452Ala Single submitter ⚠
- p.Tyr251Cys Single submitter ⚠
- p.Val166Met Single submitter ⚠
- p.Val169Ala Single submitter ⚠
- p.Val169Ile Single submitter ⚠
- p.Val44Ile Single submitter ⚠
- p.Val490Ala Single submitter ⚠