Sugi Variant

Sugi Variant/PER3

PER3 — 186 ClinVar variants

All ClinVar germline PER3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 126 flagged for review →

1 Pathogenic · 3 Likely pathogenic · 3 Conflicting · 8 Benign · 2 Benign/Likely benign · 42 Likely benign · 127 Uncertain significance

Full PER3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 126

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 108

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 16

The independent predictors disagree with each other — read with care.

All PER3 variants

Pathogenic 1

Likely pathogenic 3

Conflicting classifications of pathogenicity 3

Benign 8

Benign/Likely benign 2

Likely benign 42

Uncertain significance 127