PGC — 69 ClinVar variants
All ClinVar germline PGC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
5 Likely benign · 64 Uncertain significance
Full PGC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PGC p.Ala183Thr Uncertain significance Single submitter
- PGC p.Ala186Val Uncertain significance Single submitter
- PGC p.Ala242Val Uncertain significance Single submitter
- PGC p.Ala388Thr Uncertain significance Single submitter
- PGC p.Ala67Gly Uncertain significance Single submitter
- PGC p.Ala67Val Uncertain significance Single submitter
- PGC p.Arg114Cys Uncertain significance Single submitter
- PGC p.Arg30Cys Uncertain significance Single submitter
- PGC p.Arg30Leu Uncertain significance Single submitter
- PGC p.Arg55Gly Uncertain significance Single submitter
- PGC p.Asn126Asp Uncertain significance Single submitter
- PGC p.Asn157Lys Uncertain significance Single submitter
- PGC p.Asn165Ser Uncertain significance Single submitter
- PGC p.Asn315Asp Uncertain significance Single submitter
- PGC p.Asn85Thr Uncertain significance Single submitter
- PGC p.Asn96Lys Uncertain significance Single submitter
- PGC p.Cys10Tyr Uncertain significance Single submitter
- PGC p.Cys343Arg Uncertain significance Single submitter
- PGC p.Gln105Arg Uncertain significance Single submitter
- PGC p.Gln12Arg Uncertain significance Single submitter
- PGC p.Gln133Glu Uncertain significance Single submitter
- PGC p.Glu269Lys Uncertain significance Single submitter
- PGC p.Glu300Gln Uncertain significance Single submitter
- PGC p.Glu327Lys Uncertain significance Single submitter
- PGC p.Gly144Cys Uncertain significance Single submitter
- PGC p.Gly161Ser Uncertain significance Single submitter
- PGC p.Gly222Arg Uncertain significance Single submitter
- PGC p.Gly222Trp Uncertain significance Single submitter
- PGC p.Gly223Ala Uncertain significance Single submitter
- PGC p.Gly260Ser Uncertain significance Single submitter
- PGC p.Gly93Ser Uncertain significance Single submitter
- PGC p.Leu39Arg Uncertain significance Single submitter
- PGC p.Met69Thr Uncertain significance Single submitter
- PGC p.Phe142Val Uncertain significance Single submitter
- PGC p.Pro285Ala Uncertain significance Single submitter
- PGC p.Pro329Ser Uncertain significance Single submitter
- PGC p.Pro82Ala Uncertain significance Single submitter
- PGC p.Ser120Leu Uncertain significance Single submitter
- PGC p.Ser221Arg Uncertain significance Single submitter
- PGC p.Ser290Asn Uncertain significance Single submitter
- PGC p.Ser353Thr Uncertain significance Single submitter
- PGC p.Thr140Ala Uncertain significance Single submitter
- PGC p.Thr62Ile Uncertain significance Single submitter
- PGC p.Tyr63Cys Uncertain significance Single submitter
- PGC p.Val189Met Uncertain significance Single submitter
- PGC p.Val212Ala Uncertain significance Single submitter
- PGC p.Val275Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- PGC p.Ala174Val Uncertain significance Single submitter
- PGC p.Ala224Pro Uncertain significance Single submitter
- PGC p.Gln272Arg Uncertain significance Single submitter
- PGC p.Gly260Cys Uncertain significance Single submitter
- PGC p.Gly270Ser Uncertain significance Single submitter
- PGC p.Gly357Asp Uncertain significance Single submitter
- PGC p.Ile254Thr Uncertain significance Single submitter
- PGC p.Ile362Leu Uncertain significance Single submitter
- PGC p.Leu368Phe Uncertain significance Single submitter
- PGC p.Phe26Leu Uncertain significance Single submitter
- PGC p.Ser207Arg Uncertain significance Single submitter
- PGC p.Ser333Phe Uncertain significance Single submitter
- PGC p.Thr147Asn Uncertain significance Single submitter
All PGC variants
Likely benign 5
- p.Arg55His Single submitter
- p.Asn324Ser Single submitter
- p.Glu256= Single submitter
- p.Met289Leu Single submitter
- p.Ser232Asn Single submitter
Uncertain significance 64
- p.Ala174Val Single submitter ⚠
- p.Ala183Thr Single submitter ⚠
- p.Ala186Val Single submitter ⚠
- p.Ala224Pro Single submitter ⚠
- p.Ala242Val Single submitter ⚠
- p.Ala388Thr Single submitter ⚠
- p.Ala67Gly Single submitter ⚠
- p.Ala67Val Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg30Cys Single submitter ⚠
- p.Arg30Leu Single submitter ⚠
- p.Arg55Gly Single submitter ⚠
- p.Asn126Asp Single submitter ⚠
- p.Asn157Lys Single submitter ⚠
- p.Asn165Ser Single submitter ⚠
- p.Asn315Asp Single submitter ⚠
- p.Asn85Thr Single submitter ⚠
- p.Asn96Lys Single submitter ⚠
- p.Cys10Tyr Single submitter ⚠
- p.Cys343Arg Single submitter ⚠
- p.Gln105Arg Single submitter ⚠
- p.Gln12Arg Single submitter ⚠
- p.Gln133Glu Single submitter ⚠
- p.Gln272Arg Single submitter ⚠
- p.Glu269Lys Single submitter ⚠
- p.Glu300Gln Single submitter ⚠
- p.Glu327Lys Single submitter ⚠
- p.Gly144Cys Single submitter ⚠
- p.Gly161Ser Single submitter ⚠
- p.Gly222Arg Single submitter ⚠
- p.Gly222Trp Single submitter ⚠
- p.Gly223Ala Single submitter ⚠
- p.Gly260Cys Single submitter ⚠
- p.Gly260Ser Single submitter ⚠
- p.Gly270Ser Single submitter ⚠
- p.Gly357Asp Single submitter ⚠
- p.Gly93Ser Single submitter ⚠
- p.Ile254Thr Single submitter ⚠
- p.Ile362Leu Single submitter ⚠
- p.Leu368Phe Single submitter ⚠
- p.Leu39Arg Single submitter ⚠
- p.Leu97Phe Single submitter
- p.Met69Thr Single submitter ⚠
- p.Phe142Val Single submitter ⚠
- p.Phe26Leu Single submitter ⚠
- p.Pro167Arg Single submitter
- p.Pro285Ala Single submitter ⚠
- p.Pro329Ser Single submitter ⚠
- p.Pro82Ala Single submitter ⚠
- p.Ser120Leu Single submitter ⚠
- p.Ser121Phe Single submitter
- p.Ser207Arg Single submitter ⚠
- p.Ser221Arg Single submitter ⚠
- p.Ser290Asn Single submitter ⚠
- p.Ser333Phe Single submitter ⚠
- p.Ser353Thr Single submitter ⚠
- p.Thr140Ala Single submitter ⚠
- p.Thr147Asn Single submitter ⚠
- p.Thr62Ile Single submitter ⚠
- p.Tyr63Cys Single submitter ⚠
- p.Val189Met Single submitter ⚠
- p.Val212Ala Single submitter ⚠
- p.Val275Met Single submitter ⚠
- p.Val308Met Single submitter