PGF — 33 ClinVar variants
All ClinVar germline PGF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Likely benign · 32 Uncertain significance
Full PGF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PGF p.Ala21Thr Uncertain significance Single submitter
- PGF p.Ala54Val Uncertain significance Single submitter
- PGF p.Arg127His Uncertain significance Single submitter
- PGF p.Arg134Gln Uncertain significance Single submitter
- PGF p.Arg134Trp Uncertain significance Single submitter
- PGF p.Arg169Trp Uncertain significance Single submitter
- PGF p.Arg53Gln Uncertain significance Single submitter
- PGF p.Arg57Met Uncertain significance Single submitter
- PGF p.Arg5Lys Uncertain significance Single submitter
- PGF p.Asp113Asn Uncertain significance Single submitter
- PGF p.Asp165Asn Uncertain significance Single submitter
- PGF p.Gln12Pro Uncertain significance Single submitter
- PGF p.Glu98Gly Uncertain significance Single submitter
- PGF p.Gly164Arg Uncertain significance Single submitter
- PGF p.Gly16Ala Uncertain significance Single submitter
- PGF p.Leu133Gln Uncertain significance Single submitter
- PGF p.Pro23Ala Uncertain significance Single submitter
- PGF p.Pro23Leu Uncertain significance Single submitter
- PGF p.Ser79Pro Uncertain significance Single submitter
- PGF p.Thr99Met Uncertain significance Single submitter
- PGF p.Val118Met Uncertain significance Single submitter
- PGF p.Val126Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PGF variants
Likely benign 1
- p.Val61Ile Single submitter
Uncertain significance 32
- p.Ala21Thr Single submitter ⚠
- p.Ala54Val Single submitter ⚠
- p.Arg110Leu Single submitter ⚠
- p.Arg114Trp Single submitter ⚠
- p.Arg127Cys Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg169Trp Single submitter ⚠
- p.Arg49His Single submitter ⚠
- p.Arg53Gln Single submitter ⚠
- p.Arg57Met Single submitter ⚠
- p.Arg5Lys Single submitter ⚠
- p.Asp113Asn Single submitter ⚠
- p.Asp165Asn Single submitter ⚠
- p.Cys160Arg Single submitter
- p.Gln12Pro Single submitter ⚠
- p.Glu129Lys Single submitter
- p.Glu98Gly Single submitter ⚠
- p.Gly148Glu Single submitter
- p.Gly164Arg Single submitter ⚠
- p.Gly16Ala Single submitter ⚠
- p.Leu133Gln Single submitter ⚠
- p.Pro144Ser Single submitter
- p.Pro23Ala Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Ser79Pro Single submitter ⚠
- p.Thr121Met Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Val118Met Single submitter ⚠
- p.Val126Ile Single submitter ⚠
- p.Val40Ala Single submitter