PGK2 — 70 ClinVar variants
All ClinVar germline PGK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
70 Uncertain significance
Full PGK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PGK2 p.Ala102Thr Uncertain significance Single submitter
- PGK2 p.Ala172Thr Uncertain significance Single submitter
- PGK2 p.Arg171Cys Uncertain significance Single submitter
- PGK2 p.Arg171His Uncertain significance Single submitter
- PGK2 p.Arg18Gln Uncertain significance Single submitter
- PGK2 p.Arg22Thr Uncertain significance Single submitter
- PGK2 p.Asn110Asp Uncertain significance Single submitter
- PGK2 p.Asn121Lys Uncertain significance Single submitter
- PGK2 p.Asn180Asp Uncertain significance Single submitter
- PGK2 p.Asn321Lys Uncertain significance Single submitter
- PGK2 p.Asn337Lys Uncertain significance Single submitter
- PGK2 p.Asp13His Uncertain significance Single submitter
- PGK2 p.Asp145Glu Uncertain significance Single submitter
- PGK2 p.Asp24His Uncertain significance Single submitter
- PGK2 p.Gln33Lys Uncertain significance Single submitter
- PGK2 p.Glu252Lys Uncertain significance Single submitter
- PGK2 p.Gly101Ala Uncertain significance Single submitter
- PGK2 p.Gly137Ala Uncertain significance Single submitter
- PGK2 p.Gly239Arg Uncertain significance Single submitter
- PGK2 p.Gly317Val Uncertain significance Single submitter
- PGK2 p.Gly366Val Uncertain significance Single submitter
- PGK2 p.Ile20Met Uncertain significance Single submitter
- PGK2 p.Leu212Phe Uncertain significance Single submitter
- PGK2 p.Leu9Ser Uncertain significance Single submitter
- PGK2 p.Lys216Asn Uncertain significance Single submitter
- PGK2 p.Lys225Arg Uncertain significance Single submitter
- PGK2 p.Met227Ile Uncertain significance Single submitter
- PGK2 p.Met29Leu Uncertain significance Single submitter
- PGK2 p.Phe124Val Uncertain significance Single submitter
- PGK2 p.Phe292Leu Uncertain significance Single submitter
- PGK2 p.Pro135Thr Uncertain significance Single submitter
- PGK2 p.Pro28Leu Uncertain significance Single submitter
- PGK2 p.Pro339Leu Uncertain significance Single submitter
- PGK2 p.Ser174Arg Uncertain significance Single submitter
- PGK2 p.Ser186Thr Uncertain significance Single submitter
- PGK2 p.Ser320Asn Uncertain significance Single submitter
- PGK2 p.Ser364Pro Uncertain significance Single submitter
- PGK2 p.Ser390Asn Uncertain significance Single submitter
- PGK2 p.Ser415Cys Uncertain significance Single submitter
- PGK2 p.Thr363Ile Uncertain significance Single submitter
- PGK2 p.Tyr161His Uncertain significance Single submitter
- PGK2 p.Tyr76His Uncertain significance Single submitter
- PGK2 p.Val100Ala Uncertain significance Single submitter
- PGK2 p.Val104Ala Uncertain significance Single submitter
- PGK2 p.Val266Phe Uncertain significance Single submitter
- PGK2 p.Val27Phe Uncertain significance Single submitter
- PGK2 p.Val389Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- PGK2 p.Ala109Asp Uncertain significance Single submitter
- PGK2 p.Ala210Ser Uncertain significance Single submitter
- PGK2 p.Ala55Gly Uncertain significance Single submitter
- PGK2 p.Ala55Ser Uncertain significance Single submitter
- PGK2 p.Asn110Lys Uncertain significance Single submitter
- PGK2 p.Asn37Ser Uncertain significance Single submitter
- PGK2 p.Asn53Asp Uncertain significance Single submitter
- PGK2 p.Asp13Gly Uncertain significance Single submitter
- PGK2 p.Asp259Glu Uncertain significance Single submitter
- PGK2 p.Asp387Gly Uncertain significance Single submitter
- PGK2 p.Asp74Asn Uncertain significance Single submitter
- PGK2 p.Gly114Asp Uncertain significance Single submitter
- PGK2 p.Gly277Cys Uncertain significance Single submitter
- PGK2 p.His324Arg Uncertain significance Single submitter
- PGK2 p.Ile20Thr Uncertain significance Single submitter
- PGK2 p.Ile265Asn Uncertain significance Single submitter
- PGK2 p.Leu248Phe Uncertain significance Single submitter
- PGK2 p.Pro80Thr Uncertain significance Single submitter
- PGK2 p.Ser87Phe Uncertain significance Single submitter
- PGK2 p.Thr35Ile Uncertain significance Single submitter
- PGK2 p.Val58Ile Uncertain significance Single submitter
- PGK2 p.Val93Ile Uncertain significance Single submitter
All PGK2 variants
Uncertain significance 70
- p.Ala102Thr Single submitter ⚠
- p.Ala109Asp Single submitter ⚠
- p.Ala172Thr Single submitter ⚠
- p.Ala210Ser Single submitter ⚠
- p.Ala55Gly Single submitter ⚠
- p.Ala55Ser Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg171His Single submitter ⚠
- p.Arg18Gln Single submitter ⚠
- p.Arg22Thr Single submitter ⚠
- p.Asn110Asp Single submitter ⚠
- p.Asn110Lys Single submitter ⚠
- p.Asn121Lys Single submitter ⚠
- p.Asn180Asp Single submitter ⚠
- p.Asn321Lys Single submitter ⚠
- p.Asn337Lys Single submitter ⚠
- p.Asn37Ser Single submitter ⚠
- p.Asn53Asp Single submitter ⚠
- p.Asp13Gly Single submitter ⚠
- p.Asp13His Single submitter ⚠
- p.Asp145Glu Single submitter ⚠
- p.Asp24His Single submitter ⚠
- p.Asp259Glu Single submitter ⚠
- p.Asp387Gly Single submitter ⚠
- p.Asp74Asn Single submitter ⚠
- p.Gln33Lys Single submitter ⚠
- p.Glu233Gly Single submitter
- p.Glu252Lys Single submitter ⚠
- p.Gly101Ala Single submitter ⚠
- p.Gly114Asp Single submitter ⚠
- p.Gly137Ala Single submitter ⚠
- p.Gly239Arg Single submitter ⚠
- p.Gly277Cys Single submitter ⚠
- p.Gly317Val Single submitter ⚠
- p.Gly366Val Single submitter ⚠
- p.His324Arg Single submitter ⚠
- p.Ile20Met Single submitter ⚠
- p.Ile20Thr Single submitter ⚠
- p.Ile265Asn Single submitter ⚠
- p.Leu212Phe Single submitter ⚠
- p.Leu248Phe Single submitter ⚠
- p.Leu9Ser Single submitter ⚠
- p.Lys216Asn Single submitter ⚠
- p.Lys225Arg Single submitter ⚠
- p.Met227Ile Single submitter ⚠
- p.Met29Leu Single submitter ⚠
- p.Phe124Val Single submitter ⚠
- p.Phe292Leu Single submitter ⚠
- p.Pro135Thr Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro339Leu Single submitter ⚠
- p.Pro80Thr Single submitter ⚠
- p.Ser174Arg Single submitter ⚠
- p.Ser186Thr Single submitter ⚠
- p.Ser320Asn Single submitter ⚠
- p.Ser364Pro Single submitter ⚠
- p.Ser390Asn Single submitter ⚠
- p.Ser415Cys Single submitter ⚠
- p.Ser87Phe Single submitter ⚠
- p.Thr35Ile Single submitter ⚠
- p.Thr363Ile Single submitter ⚠
- p.Tyr161His Single submitter ⚠
- p.Tyr76His Single submitter ⚠
- p.Val100Ala Single submitter ⚠
- p.Val104Ala Single submitter ⚠
- p.Val266Phe Single submitter ⚠
- p.Val27Phe Single submitter ⚠
- p.Val389Leu Single submitter ⚠
- p.Val58Ile Single submitter ⚠
- p.Val93Ile Single submitter ⚠