PGR — 133 ClinVar variants

All ClinVar germline PGR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →

14 Benign · 1 Benign/Likely benign · 7 Likely benign · 111 Uncertain significance

Full PGR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 106

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 101

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 5

The independent predictors disagree with each other — read with care.

All PGR variants

Benign 14

p.Arg187= Multiple submitters
p.Arg623= Multiple submitters
p.Cys347Ser Multiple submitters
p.Gln536Pro Multiple submitters
p.Gln868= Multiple submitters
p.Gly263= Multiple submitters
p.Gly661= Multiple submitters
p.His204= Multiple submitters
p.Leu651Val Multiple submitters
p.Ser49= Multiple submitters
c.1789+8C>T Single submitter
p.Ala120Val Single submitter
p.Ile51Thr Single submitter
p.Pro52= Single submitter

Benign/Likely benign 1

p.Lys183= Multiple submitters

Likely benign 7

p.Gln75Lys Multiple submitters
p.Gly435= Multiple submitters
p.Ala441= Single submitter
p.Glu786= Single submitter
p.Leu311= Single submitter
p.Pro132= Single submitter
p.Tyr525= Single submitter

Uncertain significance 111

p.Ala248Glu Single submitter ⚠
p.Ala248Val Single submitter ⚠
p.Ala254Pro Single submitter ⚠
p.Ala254Thr Single submitter ⚠
p.Ala261Gly Single submitter ⚠
p.Ala277Gly Single submitter ⚠
p.Ala281Ser Single submitter ⚠
p.Ala338Thr Single submitter ⚠
p.Ala398Thr Single submitter ⚠
p.Ala407Val Single submitter ⚠
p.Ala482Thr Single submitter ⚠
p.Ala500Asp Single submitter
p.Ala503Thr Single submitter ⚠
p.Ala507Ser Single submitter ⚠
p.Ala50Asp Single submitter ⚠
p.Ala510Gly Single submitter ⚠
p.Ala510Thr Single submitter ⚠
p.Ala92Pro Single submitter ⚠
p.Arg10Gln Single submitter ⚠
p.Arg274Cys Single submitter ⚠
p.Arg293Ser Single submitter ⚠
p.Arg492Leu Single submitter ⚠
p.Arg615His Single submitter ⚠
p.Asn518Ser Single submitter ⚠
p.Asn543Ser Single submitter ⚠
p.Asn643Asp Single submitter ⚠
p.Asp326Asn Single submitter ⚠
p.Asp360Gly Single submitter ⚠
p.Asp360Val Single submitter ⚠
p.Asp379Asn Single submitter ⚠
p.Cys29Arg Single submitter ⚠
p.Cys480Gly Single submitter ⚠
p.Gln667His Single submitter ⚠
p.Gln787His Single submitter
p.Gln803His Single submitter ⚠
p.Glu224Val Single submitter ⚠
p.Glu231Lys Single submitter ⚠
p.Glu395Ala Single submitter ⚠
p.Glu395Gly Single submitter ⚠
p.Glu436Lys Single submitter ⚠
p.Glu560Lys Single submitter ⚠
p.Gly125Glu Single submitter ⚠
p.Gly173Arg Single submitter ⚠
p.Gly188Ser Single submitter ⚠
p.Gly246Ser Single submitter ⚠
p.Gly251Glu Single submitter ⚠
p.Gly331Ser Single submitter ⚠
p.Gly408Asp Single submitter ⚠
p.Gly467Cys Single submitter ⚠
p.Gly473Ser Single submitter ⚠
p.Gly484Cys Single submitter ⚠
p.Gly487Ser Single submitter ⚠
p.Gly494Ser Single submitter ⚠
p.Gly661Asp Single submitter ⚠
p.Gly66Ala Single submitter ⚠
p.His703Arg Single submitter ⚠
p.Ile856Thr Single submitter ⚠
p.Leu111Pro Single submitter ⚠
p.Leu164Ile Single submitter ⚠
p.Leu917Ser Single submitter ⚠
p.Lys270Arg Single submitter ⚠
p.Lys731Arg Single submitter ⚠
p.Lys769Glu Single submitter ⚠
p.Met289Lys Single submitter ⚠
p.Met595Val Single submitter ⚠
p.Met692Ile Single submitter ⚠
p.Met775Val Single submitter
p.Phe414Ser Single submitter ⚠
p.Pro124Ser Single submitter ⚠
p.Pro129Ser Single submitter ⚠
p.Pro148Ser Single submitter ⚠
p.Pro151Gln Single submitter ⚠
p.Pro214Ala Single submitter ⚠
p.Pro21Ser Single submitter ⚠
p.Pro235Leu Single submitter ⚠
p.Pro288Arg Single submitter ⚠
p.Pro346Leu Single submitter ⚠
p.Pro359Ser Single submitter ⚠
p.Pro37Leu Single submitter ⚠
p.Pro382Leu Single submitter ⚠
p.Pro411Ala Single submitter ⚠
p.Pro415Arg Single submitter ⚠
p.Pro415Leu Single submitter ⚠
p.Pro424Arg Single submitter ⚠
p.Pro434Arg Single submitter ⚠
p.Pro491Arg Single submitter ⚠
p.Pro491Ser Single submitter ⚠
p.Pro539Ser Single submitter ⚠
p.Pro540Thr Single submitter ⚠
p.Pro708Ser Single submitter
p.Pro927His Single submitter ⚠
p.Ser138Asn Single submitter ⚠
p.Ser175Gly Single submitter ⚠
p.Ser202Gly Single submitter ⚠
p.Ser294Tyr Single submitter ⚠
p.Ser345Leu Single submitter ⚠
p.Ser693Gly Single submitter ⚠
p.Thr117Pro Single submitter
p.Thr299Lys Single submitter ⚠
p.Thr41Ile Single submitter ⚠
p.Thr457Asn Single submitter ⚠
p.Tyr374Asp Single submitter ⚠
p.Tyr538Cys Single submitter ⚠
p.Tyr557Cys Single submitter ⚠
p.Tyr871Cys Single submitter ⚠
p.Tyr87Asn Single submitter ⚠
p.Val160Ala Single submitter ⚠
p.Val221Asp Single submitter ⚠
p.Val221Ile Single submitter ⚠
p.Val448Ala Single submitter ⚠
p.Val662Leu Single submitter ⚠