PHLPP2 — 191 ClinVar variants

All ClinVar germline PHLPP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 175 flagged for review →

1 Benign · 8 Likely benign · 182 Uncertain significance

Full PHLPP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 175

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 137

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 38

The independent predictors disagree with each other — read with care.

All PHLPP2 variants

Benign 1

p.His1002= Single submitter

Likely benign 8

p.Ile204Val Multiple submitters
p.Ser1139Cys Multiple submitters
p.Gln471His Single submitter
p.His1285Arg Single submitter
p.Ile316Val Single submitter
p.Leu327= Single submitter
p.Leu514= Single submitter
p.Phe506Ser Single submitter

Uncertain significance 182

p.Asp453Gly Multiple submitters ⚠
p.Ala1008Thr Single submitter ⚠
p.Ala1008Val Single submitter ⚠
p.Ala1270Ser Single submitter ⚠
p.Ala1322Val Single submitter ⚠
p.Ala223Pro Single submitter ⚠
p.Ala581Thr Single submitter ⚠
p.Ala612Thr Single submitter ⚠
p.Ala652Ser Single submitter ⚠
p.Ala652Val Single submitter ⚠
p.Ala73Ser Single submitter ⚠
p.Ala73Val Single submitter ⚠
p.Ala792Ser Single submitter ⚠
p.Ala885Asp Single submitter ⚠
p.Ala888Glu Single submitter ⚠
p.Ala903Glu Single submitter ⚠
p.Arg1116Gln Single submitter ⚠
p.Arg1117His Single submitter ⚠
p.Arg1131Cys Single submitter ⚠
p.Arg1177Trp Single submitter ⚠
p.Arg121Cys Single submitter ⚠
p.Arg121His Single submitter ⚠
p.Arg1302Trp Single submitter ⚠
p.Arg1312Trp Single submitter ⚠
p.Arg172Cys Single submitter ⚠
p.Arg21Gly Single submitter ⚠
p.Arg241Gln Single submitter ⚠
p.Arg3Cys Single submitter ⚠
p.Arg469Gln Single submitter ⚠
p.Arg483Gln Single submitter ⚠
p.Arg483Trp Single submitter
p.Arg823Gln Single submitter ⚠
p.Arg829His Single submitter ⚠
p.Arg82Ile Single submitter ⚠
p.Arg907Gln Single submitter ⚠
p.Arg951Gly Single submitter ⚠
p.Asn1242Ile Single submitter ⚠
p.Asn1242Ser Single submitter ⚠
p.Asn328Ser Single submitter ⚠
p.Asn355Asp Single submitter ⚠
p.Asn401Asp Single submitter ⚠
p.Asn630His Single submitter ⚠
p.Asn701Thr Single submitter ⚠
p.Asn8His Single submitter ⚠
p.Asp1024Gly Single submitter ⚠
p.Asp1150His Single submitter ⚠
p.Asp117Gly Single submitter ⚠
p.Asp1286Val Single submitter ⚠
p.Asp188His Single submitter ⚠
p.Asp336His Single submitter ⚠
p.Asp453Tyr Single submitter ⚠
p.Asp508Gly Single submitter ⚠
p.Asp519Asn Single submitter ⚠
p.Asp724Gly Single submitter ⚠
p.Asp768Gly Single submitter
p.Asp820Val Single submitter ⚠
p.Cys1174Phe Single submitter ⚠
p.Cys258Phe Single submitter
p.Cys319Arg Single submitter ⚠
p.Cys460Arg Single submitter ⚠
p.Cys460Ser Single submitter ⚠
p.Cys522Ser Single submitter ⚠
p.Gln1142His Single submitter ⚠
p.Gln1227Arg Single submitter ⚠
p.Gln655Arg Single submitter ⚠
p.Gln869Arg Single submitter ⚠
p.Gln928Arg Single submitter ⚠
p.Glu1290Val Single submitter ⚠
p.Glu231Asp Single submitter ⚠
p.Glu404Gly Single submitter ⚠
p.Glu573Lys Single submitter ⚠
p.Glu727Lys Single submitter ⚠
p.Glu826Asp Single submitter ⚠
p.Glu826Lys Single submitter ⚠
p.Glu83Gly Single submitter ⚠
p.Gly1039Cys Single submitter ⚠
p.Gly1054Arg Single submitter ⚠
p.Gly1146Ser Single submitter
p.Gly132Ala Single submitter ⚠
p.Gly132Ser Single submitter ⚠
p.Gly908Asp Single submitter ⚠
p.His1285Asn Single submitter ⚠
p.His1308Arg Single submitter ⚠
p.His308Tyr Single submitter ⚠
p.His443Gln Single submitter ⚠
p.His557Asn Single submitter ⚠
p.His559Gln Single submitter ⚠
p.His63Gln Single submitter ⚠
p.His650Gln Single submitter ⚠
p.His753Arg Single submitter ⚠
p.His761Asp Single submitter ⚠
p.His861Asp Single submitter ⚠
p.Ile1061Val Single submitter ⚠
p.Ile182Met Single submitter ⚠
p.Ile383Val Single submitter ⚠
p.Ile968Val Single submitter ⚠
p.Leu277Phe Single submitter ⚠
p.Leu367Val Single submitter ⚠
p.Leu609Ser Single submitter ⚠
p.Leu62Ile Single submitter ⚠
p.Leu62Ser Single submitter ⚠
p.Leu743Val Single submitter ⚠
p.Leu89Val Single submitter ⚠
p.Leu963Phe Single submitter ⚠
p.Leu979Met Single submitter ⚠
p.Lys245Glu Single submitter ⚠
p.Lys310Arg Single submitter ⚠
p.Lys679Asn Single submitter ⚠
p.Lys691Arg Single submitter ⚠
p.Lys931Asn Single submitter ⚠
p.Met1215Val Single submitter ⚠
p.Met134Val Single submitter ⚠
p.Met392Lys Single submitter ⚠
p.Met392Val Single submitter ⚠
p.Met430Thr Single submitter ⚠
p.Met853Ile Single submitter ⚠
p.Met952Ile Single submitter ⚠
p.Phe16Leu Single submitter ⚠
p.Phe808Leu Single submitter ⚠
p.Pro1070Ala Single submitter ⚠
p.Pro1112Leu Single submitter ⚠
p.Pro1122Thr Single submitter ⚠
p.Pro1183Ser Single submitter ⚠
p.Pro1184Ala Single submitter ⚠
p.Pro1284Leu Single submitter
p.Pro1307Leu Single submitter ⚠
p.Pro198Leu Single submitter ⚠
p.Pro315Leu Single submitter ⚠
p.Pro338Leu Single submitter ⚠
p.Pro72Thr Single submitter ⚠
p.Pro731Ala Single submitter ⚠
p.Pro882Ala Single submitter ⚠
p.Pro972Leu Single submitter ⚠
p.Ser1073Asn Single submitter ⚠
p.Ser217Thr Single submitter ⚠
p.Ser229Gly Single submitter ⚠
p.Ser260Arg Single submitter ⚠
p.Ser371Pro Single submitter ⚠
p.Ser478Gly Single submitter ⚠
p.Ser488Gly Single submitter ⚠
p.Ser50Tyr Single submitter ⚠
p.Ser51Phe Single submitter ⚠
p.Ser52Cys Single submitter ⚠
p.Ser547Gly Single submitter ⚠
p.Ser57Phe Single submitter ⚠
p.Ser608Phe Single submitter ⚠
p.Ser60Phe Single submitter ⚠
p.Ser620Arg Single submitter ⚠
p.Ser777Thr Single submitter ⚠
p.Ser84Gly Single submitter ⚠
p.Ser890Gly Single submitter ⚠
p.Thr1058Ala Single submitter ⚠
p.Thr1069Ala Single submitter ⚠
p.Thr1123Pro Single submitter ⚠
p.Thr1125Asn Single submitter ⚠
p.Thr1321Ile Single submitter ⚠
p.Thr191Ser Single submitter ⚠
p.Thr538Ala Single submitter ⚠
p.Thr583Met Single submitter ⚠
p.Thr633Met Single submitter ⚠
p.Thr695Ile Single submitter ⚠
p.Thr774Ser Single submitter ⚠
p.Thr834Met Single submitter
p.Thr900Met Single submitter ⚠
p.Tyr1020Cys Single submitter
p.Tyr108Cys Single submitter ⚠
p.Tyr259Cys Single submitter ⚠
p.Tyr270Cys Single submitter ⚠
p.Tyr276Cys Single submitter ⚠
p.Tyr36Cys Single submitter ⚠
p.Tyr816His Single submitter ⚠
p.Val107Ile Single submitter ⚠
p.Val1089Leu Single submitter ⚠
p.Val1158Ile Single submitter ⚠
p.Val1261Met Single submitter ⚠
p.Val1283Ala Single submitter ⚠
p.Val159Leu Single submitter ⚠
p.Val532Met Single submitter ⚠
p.Val567Ala Single submitter ⚠
p.Val639Phe Single submitter ⚠
p.Val838Ala Single submitter ⚠
p.Val930Met Single submitter ⚠