PIK3R3 — 4 ClinVar variants
All ClinVar germline PIK3R3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
1 Likely benign · 3 Uncertain significance
Full PIK3R3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All PIK3R3 variants
Likely benign 1
- c.764+2dup No assertion criteria
Uncertain significance 3
- p.Ala92Val Single submitter ⚠
- p.Lys387Arg Single submitter ⚠
- p.Arg266His No assertion criteria hereditary breast carcinoma ⚠