PIM1 — 12 ClinVar variants
All ClinVar germline PIM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
2 Benign · 1 Likely benign · 9 Uncertain significance
Full PIM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All PIM1 variants
Likely benign 1
- p.Asn160Ser Single submitter
Uncertain significance 9
- p.Asp131Glu Single submitter ⚠
- p.Glu282Ala Single submitter ⚠
- p.Glu301Asp Single submitter ⚠
- p.His11Leu Single submitter ⚠
- p.Ile240Val Single submitter ⚠
- p.Leu143Gln Single submitter ⚠
- p.Pro309Gln Single submitter ⚠
- p.Ser308Leu Single submitter ⚠
- p.Val259Ile Single submitter ⚠