PIM2 — 17 ClinVar variants
All ClinVar germline PIM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
1 Likely benign · 16 Uncertain significance
Full PIM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PIM2 p.Arg101Cys Uncertain significance Single submitter
- PIM2 p.Arg264Cys Uncertain significance Single submitter
- PIM2 p.Arg274Gln Uncertain significance Single submitter
- PIM2 p.Asp191Asn Uncertain significance Single submitter
- PIM2 p.Asp196Tyr Uncertain significance Single submitter
- PIM2 p.Gly138Ala Uncertain significance Single submitter
- PIM2 p.Gly138Asp Uncertain significance Single submitter
- PIM2 p.His215Arg Uncertain significance Single submitter
- PIM2 p.Pro36Ser Uncertain significance Single submitter
- PIM2 p.Ser72Cys Uncertain significance Single submitter
- PIM2 p.Thr288Ile Uncertain significance Single submitter
- PIM2 p.Trp307Cys Uncertain significance Single submitter
- PIM2 p.Tyr128Cys Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All PIM2 variants
Likely benign 1
- p.Tyr203= Single submitter
Uncertain significance 16
- p.Ala122Thr Single submitter ⚠
- p.Arg101Cys Single submitter ⚠
- p.Arg141Cys Single submitter ⚠
- p.Arg264Cys Single submitter ⚠
- p.Arg274Gln Single submitter ⚠
- p.Asp191Asn Single submitter ⚠
- p.Asp196Tyr Single submitter ⚠
- p.Gly138Ala Single submitter ⚠
- p.Gly138Asp Single submitter ⚠
- p.His215Arg Single submitter ⚠
- p.Pro289Ser Single submitter ⚠
- p.Pro36Ser Single submitter ⚠
- p.Ser72Cys Single submitter ⚠
- p.Thr288Ile Single submitter ⚠
- p.Trp307Cys Single submitter ⚠
- p.Tyr128Cys Single submitter ⚠