PIM3 — 41 ClinVar variants
All ClinVar germline PIM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
4 Benign · 1 Likely benign · 36 Uncertain significance
Full PIM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PIM3 p.Ala103Val Uncertain significance Single submitter
- PIM3 p.Ala31Gly Uncertain significance Single submitter
- PIM3 p.Ala31Val Uncertain significance Single submitter
- PIM3 p.Arg104Cys Uncertain significance Single submitter
- PIM3 p.Arg181Pro Uncertain significance Single submitter
- PIM3 p.Arg255Leu Uncertain significance Single submitter
- PIM3 p.Arg307Gly Uncertain significance Single submitter
- PIM3 p.Asp117Tyr Uncertain significance Single submitter
- PIM3 p.Asp170Gly Uncertain significance Single submitter
- PIM3 p.Asp312Asn Uncertain significance Single submitter
- PIM3 p.Glu249Ala Uncertain significance Single submitter
- PIM3 p.Glu302Ala Uncertain significance Single submitter
- PIM3 p.Gly101Ala Uncertain significance Single submitter
- PIM3 p.Gly118Ser Uncertain significance Single submitter
- PIM3 p.Gly84Asp Uncertain significance Single submitter
- PIM3 p.His162Gln Uncertain significance Single submitter
- PIM3 p.Leu234Val Uncertain significance Single submitter
- PIM3 p.Lys33Arg Uncertain significance Single submitter
- PIM3 p.Phe204Leu Uncertain significance Single submitter
- PIM3 p.Pro145Ala Uncertain significance Single submitter
- PIM3 p.Pro291Ala Uncertain significance Single submitter
- PIM3 p.Thr310Ile Uncertain significance Single submitter
- PIM3 p.Thr320Met Uncertain significance Single submitter
- PIM3 p.Val106Ile Uncertain significance Single submitter
- PIM3 p.Val167Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- PIM3 p.Arg108His Uncertain significance Single submitter
- PIM3 p.Arg259Gln Uncertain significance Single submitter
- PIM3 p.Arg277Trp Uncertain significance Single submitter
- PIM3 p.Asp143Asn Uncertain significance Single submitter
- PIM3 p.Glu114Gln Uncertain significance Single submitter
- PIM3 p.Glu249Lys Uncertain significance Single submitter
- PIM3 p.Gly57Ser Uncertain significance Single submitter
- PIM3 p.Gly80Ser Uncertain significance Single submitter
- PIM3 p.Leu196Val Uncertain significance Single submitter
- PIM3 p.Trp272Gly Uncertain significance Single submitter
All PIM3 variants
Benign 4
- p.Asp32Glu Multiple submitters
- p.His222= Multiple submitters
- p.Pro313Ser Multiple submitters
- p.Val300Ala Multiple submitters
Likely benign 1
- p.Glu302Asp Single submitter
Uncertain significance 36
- p.Ala103Val Single submitter ⚠
- p.Ala31Gly Single submitter ⚠
- p.Ala31Val Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg181Pro Single submitter ⚠
- p.Arg255Leu Single submitter ⚠
- p.Arg259Gln Single submitter ⚠
- p.Arg277Trp Single submitter ⚠
- p.Arg307Gly Single submitter ⚠
- p.Asp117Tyr Single submitter ⚠
- p.Asp143Asn Single submitter ⚠
- p.Asp170Gly Single submitter ⚠
- p.Asp312Asn Single submitter ⚠
- p.Glu114Gln Single submitter ⚠
- p.Glu249Ala Single submitter ⚠
- p.Glu249Lys Single submitter ⚠
- p.Glu302Ala Single submitter ⚠
- p.Gly101Ala Single submitter ⚠
- p.Gly118Ser Single submitter ⚠
- p.Gly57Ser Single submitter ⚠
- p.Gly80Ser Single submitter ⚠
- p.Gly84Asp Single submitter ⚠
- p.His162Gln Single submitter ⚠
- p.Leu196Val Single submitter ⚠
- p.Leu234Val Single submitter ⚠
- p.Lys33Arg Single submitter ⚠
- p.Phe204Leu Single submitter ⚠
- p.Pro145Ala Single submitter ⚠
- p.Pro291Ala Single submitter ⚠
- p.Thr310Ile Single submitter ⚠
- p.Thr320Met Single submitter ⚠
- p.Trp272Gly Single submitter ⚠
- p.Val106Ile Single submitter ⚠
- p.Val158fs Single submitter
- p.Val167Leu Single submitter ⚠