PIN4 — 16 ClinVar variants
All ClinVar germline PIN4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
16 Uncertain significance
Full PIN4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All PIN4 variants
Uncertain significance 16
- c.41T>G Single submitter
- c.-16A>T Single submitter
- c.-21G>C Single submitter
- c.-2A>G Single submitter
- c.-5C>G Single submitter
- p.Arg12Gly Single submitter
- p.Gly30Val Single submitter ⚠
- p.Leu82Val Single submitter ⚠
- p.Met3Arg Single submitter
- p.Met3Leu Single submitter
- p.Met3Thr Single submitter
- p.Met55Val Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro93Gln Single submitter ⚠
- p.Val116Ile Single submitter ⚠
- p.Val11Ile Single submitter