PKN2 — 79 ClinVar variants
All ClinVar germline PKN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
2 Likely benign · 77 Uncertain significance
Full PKN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PKN2 p.Ala30Thr Uncertain significance Single submitter
- PKN2 p.Ala355Pro Uncertain significance Single submitter
- PKN2 p.Arg130His Uncertain significance Single submitter
- PKN2 p.Arg130Leu Uncertain significance Single submitter
- PKN2 p.Arg20Gln Uncertain significance Single submitter
- PKN2 p.Arg223Lys Uncertain significance Single submitter
- PKN2 p.Arg223Ser Uncertain significance Single submitter
- PKN2 p.Arg381Gln Uncertain significance Single submitter
- PKN2 p.Arg550His Uncertain significance Single submitter
- PKN2 p.Arg580Gln Uncertain significance Single submitter
- PKN2 p.Arg594Gly Uncertain significance Single submitter
- PKN2 p.Arg964Ser Uncertain significance Single submitter
- PKN2 p.Asn280Lys Uncertain significance Single submitter
- PKN2 p.Asn678Ser Uncertain significance Single submitter
- PKN2 p.Asn84Asp Uncertain significance Single submitter
- PKN2 p.Asn895Ser Uncertain significance Single submitter
- PKN2 p.Asp976Ala Uncertain significance Single submitter
- PKN2 p.Gln142Lys Uncertain significance Single submitter
- PKN2 p.Gln181Arg Uncertain significance Single submitter
- PKN2 p.Gln553His Uncertain significance Single submitter
- PKN2 p.Gln647His Uncertain significance Single submitter
- PKN2 p.Glu904Lys Uncertain significance Single submitter
- PKN2 p.Gly600Glu Uncertain significance Single submitter
- PKN2 p.Gly691Glu Uncertain significance Single submitter
- PKN2 p.Ile312Thr Uncertain significance Single submitter
- PKN2 p.Ile341Met Uncertain significance Single submitter
- PKN2 p.Ile495Asn Uncertain significance Single submitter
- PKN2 p.Ile887Val Uncertain significance Single submitter
- PKN2 p.Ile965Thr Uncertain significance Single submitter
- PKN2 p.Leu180His Uncertain significance Single submitter
- PKN2 p.Leu900Val Uncertain significance Single submitter
- PKN2 p.Lys797Thr Uncertain significance Single submitter
- PKN2 p.Lys927Arg Uncertain significance Single submitter
- PKN2 p.Met369Ile Uncertain significance Single submitter
- PKN2 p.Met973Ile Uncertain significance Single submitter
- PKN2 p.Phe607Ser Uncertain significance Single submitter
- PKN2 p.Phe657Cys Uncertain significance Single submitter
- PKN2 p.Phe683Val Uncertain significance Single submitter
- PKN2 p.Pro23Leu Uncertain significance Single submitter
- PKN2 p.Pro541Ser Uncertain significance Single submitter
- PKN2 p.Pro575Thr Uncertain significance Single submitter
- PKN2 p.Pro718Thr Uncertain significance Single submitter
- PKN2 p.Ser289Asn Uncertain significance Single submitter
- PKN2 p.Ser310Thr Uncertain significance Single submitter
- PKN2 p.Ser366Leu Uncertain significance Single submitter
- PKN2 p.Ser582Ala Uncertain significance Single submitter
- PKN2 p.Ser622Pro Uncertain significance Single submitter
- PKN2 p.Ser922Asn Uncertain significance Single submitter
- PKN2 p.Thr13Ala Uncertain significance Single submitter
- PKN2 p.Thr13Arg Uncertain significance Single submitter
- PKN2 p.Thr314Met Uncertain significance Single submitter
- PKN2 p.Thr364Ile Uncertain significance Single submitter
- PKN2 p.Trp437Arg Uncertain significance Single submitter
- PKN2 p.Val282Ile Uncertain significance Single submitter
- PKN2 p.Val354Phe Uncertain significance Single submitter
- PKN2 p.Val544Met Uncertain significance Single submitter
- PKN2 p.Val699Ile Uncertain significance Single submitter
- PKN2 p.Val715Ile Uncertain significance Single submitter
- PKN2 p.Val767Gly Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- PKN2 p.Ala923Thr Uncertain significance Single submitter
- PKN2 p.Arg438His Uncertain significance Single submitter
- PKN2 p.Cys660Trp Uncertain significance Single submitter
- PKN2 p.Glu220Lys Uncertain significance Single submitter
- PKN2 p.Gly378Arg Uncertain significance Single submitter
- PKN2 p.Gly769Ala Uncertain significance Single submitter
- PKN2 p.Leu180Phe Uncertain significance Single submitter
- PKN2 p.Met682Thr Uncertain significance Single submitter
- PKN2 p.Pro914Leu Uncertain significance Single submitter
- PKN2 p.Ser373Arg Uncertain significance Single submitter
- PKN2 p.Ser416Leu Uncertain significance Single submitter
- PKN2 p.Ser535Asn Uncertain significance Single submitter
- PKN2 p.Ser967Leu Uncertain significance Single submitter
- PKN2 p.Tyr318Cys Uncertain significance Single submitter
- PKN2 p.Tyr810Cys Uncertain significance Single submitter
- PKN2 p.Val108Ala Uncertain significance Single submitter
All PKN2 variants
Likely benign 2
- p.Met40Val Single submitter
- p.Val760= Single submitter
Uncertain significance 77
- c.2562+1dup Single submitter
- p.Ala30Thr Single submitter ⚠
- p.Ala355Pro Single submitter ⚠
- p.Ala923Thr Single submitter ⚠
- p.Arg130His Single submitter ⚠
- p.Arg130Leu Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg223Lys Single submitter ⚠
- p.Arg223Ser Single submitter ⚠
- p.Arg381Gln Single submitter ⚠
- p.Arg438His Single submitter ⚠
- p.Arg550His Single submitter ⚠
- p.Arg580Gln Single submitter ⚠
- p.Arg594Gly Single submitter ⚠
- p.Arg964Ser Single submitter ⚠
- p.Asn280Lys Single submitter ⚠
- p.Asn678Ser Single submitter ⚠
- p.Asn84Asp Single submitter ⚠
- p.Asn895Ser Single submitter ⚠
- p.Asp976Ala Single submitter ⚠
- p.Cys660Trp Single submitter ⚠
- p.Gln142Lys Single submitter ⚠
- p.Gln181Arg Single submitter ⚠
- p.Gln553His Single submitter ⚠
- p.Gln647His Single submitter ⚠
- p.Glu220Lys Single submitter ⚠
- p.Glu904Lys Single submitter ⚠
- p.Gly378Arg Single submitter ⚠
- p.Gly600Glu Single submitter ⚠
- p.Gly691Glu Single submitter ⚠
- p.Gly769Ala Single submitter ⚠
- p.Ile312Thr Single submitter ⚠
- p.Ile341Met Single submitter ⚠
- p.Ile495Asn Single submitter ⚠
- p.Ile887Val Single submitter ⚠
- p.Ile965Thr Single submitter ⚠
- p.Leu180His Single submitter ⚠
- p.Leu180Phe Single submitter ⚠
- p.Leu900Val Single submitter ⚠
- p.Lys797Thr Single submitter ⚠
- p.Lys927Arg Single submitter ⚠
- p.Met369Ile Single submitter ⚠
- p.Met682Thr Single submitter ⚠
- p.Met973Ile Single submitter ⚠
- p.Phe479Ser Single submitter
- p.Phe607Ser Single submitter ⚠
- p.Phe657Cys Single submitter ⚠
- p.Phe683Val Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro541Ser Single submitter ⚠
- p.Pro575Thr Single submitter ⚠
- p.Pro718Thr Single submitter ⚠
- p.Pro914Leu Single submitter ⚠
- p.Ser289Asn Single submitter ⚠
- p.Ser310Thr Single submitter ⚠
- p.Ser366Leu Single submitter ⚠
- p.Ser373Arg Single submitter ⚠
- p.Ser416Leu Single submitter ⚠
- p.Ser535Asn Single submitter ⚠
- p.Ser582Ala Single submitter ⚠
- p.Ser622Pro Single submitter ⚠
- p.Ser922Asn Single submitter ⚠
- p.Ser967Leu Single submitter ⚠
- p.Thr13Ala Single submitter ⚠
- p.Thr13Arg Single submitter ⚠
- p.Thr314Met Single submitter ⚠
- p.Thr364Ile Single submitter ⚠
- p.Trp437Arg Single submitter ⚠
- p.Tyr318Cys Single submitter ⚠
- p.Tyr810Cys Single submitter ⚠
- p.Val108Ala Single submitter ⚠
- p.Val282Ile Single submitter ⚠
- p.Val354Phe Single submitter ⚠
- p.Val544Met Single submitter ⚠
- p.Val699Ile Single submitter ⚠
- p.Val715Ile Single submitter ⚠
- p.Val767Gly Single submitter ⚠