PLA2G10 — 9 ClinVar variants
All ClinVar germline PLA2G10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
2 Likely benign · 7 Uncertain significance
Full PLA2G10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLA2G10 p.Asp160Asn Uncertain significance Single submitter
- PLA2G10 p.Cys130Ser Uncertain significance Single submitter
- PLA2G10 p.Cys139Phe Uncertain significance Single submitter
- PLA2G10 p.Lys124Thr Uncertain significance Single submitter
- PLA2G10 p.Pro120Leu Uncertain significance Single submitter
- PLA2G10 p.Pro159Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All PLA2G10 variants
Likely benign 2
- p.Pro120= Multiple submitters
- p.Val116Ile Single submitter
Uncertain significance 7
- p.Asp160Asn Single submitter ⚠
- p.Cys130Ser Single submitter ⚠
- p.Cys139Phe Single submitter ⚠
- p.Leu129Phe Single submitter ⚠
- p.Lys124Thr Single submitter ⚠
- p.Pro120Leu Single submitter ⚠
- p.Pro159Leu Single submitter ⚠