PLA2G12A — 40 ClinVar variants
All ClinVar germline PLA2G12A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
1 Likely benign · 39 Uncertain significance
Full PLA2G12A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLA2G12A p.Ala8Val Uncertain significance Single submitter
- PLA2G12A p.Arg137Gln Uncertain significance Single submitter
- PLA2G12A p.Arg6Leu Uncertain significance Single submitter
- PLA2G12A p.Arg76Cys Uncertain significance Single submitter
- PLA2G12A p.Asn97Ser Uncertain significance Single submitter
- PLA2G12A p.Asp125Asn Uncertain significance Single submitter
- PLA2G12A p.Asp60Asn Uncertain significance Single submitter
- PLA2G12A p.Cys107Trp Uncertain significance Single submitter
- PLA2G12A p.Cys117Trp Uncertain significance Single submitter
- PLA2G12A p.Cys131Phe Uncertain significance Single submitter
- PLA2G12A p.Cys179Ser Uncertain significance Single submitter
- PLA2G12A p.Glu157Gly Uncertain significance Single submitter
- PLA2G12A p.Glu185Gly Uncertain significance Single submitter
- PLA2G12A p.Gly86Ala Uncertain significance Single submitter
- PLA2G12A p.His43Arg Uncertain significance Single submitter
- PLA2G12A p.Ile100Val Uncertain significance Single submitter
- PLA2G12A p.Ile164Val Uncertain significance Single submitter
- PLA2G12A p.Ile98Val Uncertain significance Single submitter
- PLA2G12A p.Leu11Phe Uncertain significance Single submitter
- PLA2G12A p.Leu4Pro Uncertain significance Single submitter
- PLA2G12A p.Lys80Arg Uncertain significance Single submitter
- PLA2G12A p.Pro73Thr Uncertain significance Single submitter
- PLA2G12A p.Thr146Ile Uncertain significance Single submitter
- PLA2G12A p.Thr28Asn Uncertain significance Single submitter
- PLA2G12A p.Thr28Ile Uncertain significance Single submitter
- PLA2G12A p.Thr28Ser Uncertain significance Single submitter
- PLA2G12A p.Thr47Met Uncertain significance Single submitter
- PLA2G12A p.Tyr114Cys Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- PLA2G12A p.Ala33Pro Uncertain significance Single submitter
- PLA2G12A p.Arg76His Uncertain significance Single submitter
- PLA2G12A p.Asp54Asn Uncertain significance Single submitter
- PLA2G12A p.Asp54Glu Uncertain significance Single submitter
- PLA2G12A p.Cys107Tyr Uncertain significance Single submitter
- PLA2G12A p.Gly144Arg Uncertain significance Single submitter
- PLA2G12A p.Ile164Lys Uncertain significance Single submitter
- PLA2G12A p.Leu55Pro Uncertain significance Single submitter
- PLA2G12A p.Lys105Asn Uncertain significance Single submitter
- PLA2G12A p.Ser5Trp Uncertain significance Single submitter
All PLA2G12A variants
Likely benign 1
- p.Gln25Glu Single submitter
Uncertain significance 39
- p.Ala33Pro Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg6Leu Single submitter ⚠
- p.Arg76Cys Single submitter ⚠
- p.Arg76His Single submitter ⚠
- p.Asn97Ser Single submitter ⚠
- p.Asp125Asn Single submitter ⚠
- p.Asp54Asn Single submitter ⚠
- p.Asp54Glu Single submitter ⚠
- p.Asp60Asn Single submitter ⚠
- p.Asp69Gly Single submitter
- p.Cys107Trp Single submitter ⚠
- p.Cys107Tyr Single submitter ⚠
- p.Cys117Trp Single submitter ⚠
- p.Cys131Phe Single submitter ⚠
- p.Cys179Ser Single submitter ⚠
- p.Glu157Gly Single submitter ⚠
- p.Glu185Gly Single submitter ⚠
- p.Gly144Arg Single submitter ⚠
- p.Gly86Ala Single submitter ⚠
- p.His43Arg Single submitter ⚠
- p.Ile100Val Single submitter ⚠
- p.Ile164Lys Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile98Val Single submitter ⚠
- p.Leu11Phe Single submitter ⚠
- p.Leu4Pro Single submitter ⚠
- p.Leu55Pro Single submitter ⚠
- p.Lys105Asn Single submitter ⚠
- p.Lys80Arg Single submitter ⚠
- p.Pro73Thr Single submitter ⚠
- p.Ser5Trp Single submitter ⚠
- p.Thr146Ile Single submitter ⚠
- p.Thr28Asn Single submitter ⚠
- p.Thr28Ile Single submitter ⚠
- p.Thr28Ser Single submitter ⚠
- p.Thr47Met Single submitter ⚠
- p.Tyr114Cys Single submitter ⚠