PLA2G12B — 21 ClinVar variants
All ClinVar germline PLA2G12B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Likely benign · 20 Uncertain significance
Full PLA2G12B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLA2G12B p.Arg128His Uncertain significance Single submitter
- PLA2G12B p.Arg134Gln Uncertain significance Single submitter
- PLA2G12B p.Arg146Gln Uncertain significance Single submitter
- PLA2G12B p.Arg37Gln Uncertain significance Single submitter
- PLA2G12B p.Arg69Gln Uncertain significance Single submitter
- PLA2G12B p.Cys136Phe Uncertain significance Single submitter
- PLA2G12B p.Cys88Arg Uncertain significance Single submitter
- PLA2G12B p.Glu28Gly Uncertain significance Single submitter
- PLA2G12B p.Gly87Cys Uncertain significance Single submitter
- PLA2G12B p.Pro98Ser Uncertain significance Single submitter
- PLA2G12B p.Ser139Leu Uncertain significance Single submitter
- PLA2G12B p.Ser13Gly Uncertain significance Single submitter
- PLA2G12B p.Ser24Arg Uncertain significance Single submitter
- PLA2G12B p.Thr23Met Uncertain significance Single submitter
- PLA2G12B p.Val46Ile Uncertain significance Single submitter
- PLA2G12B p.Val63Phe Uncertain significance Single submitter
- PLA2G12B p.Val97Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All PLA2G12B variants
Likely benign 1
- p.Gly89Ser Single submitter
Uncertain significance 20
- p.Arg128His Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg37Gln Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Asp33Tyr Single submitter ⚠
- p.Asp51Glu Single submitter
- p.Asp51Tyr Single submitter ⚠
- p.Cys136Phe Single submitter ⚠
- p.Cys88Arg Single submitter ⚠
- p.Glu28Gly Single submitter ⚠
- p.Gly87Cys Single submitter ⚠
- p.Pro98Ser Single submitter ⚠
- p.Ser139Leu Single submitter ⚠
- p.Ser13Gly Single submitter ⚠
- p.Ser24Arg Single submitter ⚠
- p.Thr23Met Single submitter ⚠
- p.Val46Ile Single submitter ⚠
- p.Val63Phe Single submitter ⚠
- p.Val97Ile Single submitter ⚠