PLA2G1B — 22 ClinVar variants
All ClinVar germline PLA2G1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Benign · 1 Likely benign · 20 Uncertain significance
Full PLA2G1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLA2G1B p.Ala115Gly Uncertain significance Single submitter
- PLA2G1B p.Ala15Thr Uncertain significance Single submitter
- PLA2G1B p.Asn123Ser Uncertain significance Single submitter
- PLA2G1B p.Asp121Asn Uncertain significance Single submitter
- PLA2G1B p.Asp121Tyr Uncertain significance Single submitter
- PLA2G1B p.Asp39Glu Uncertain significance Single submitter
- PLA2G1B p.Cys83Arg Uncertain significance Single submitter
- PLA2G1B p.Glu112Gly Uncertain significance Single submitter
- PLA2G1B p.Gly55Asp Uncertain significance Single submitter
- PLA2G1B p.His70Tyr Uncertain significance Single submitter
- PLA2G1B p.Pro90Gln Uncertain significance Single submitter
- PLA2G1B p.Thr58Asn Uncertain significance Single submitter
- PLA2G1B p.Thr92Ile Uncertain significance Single submitter
- PLA2G1B p.Tyr133Cys Uncertain significance Single submitter
- PLA2G1B p.Tyr91Cys Uncertain significance Single submitter
- PLA2G1B p.Val5Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PLA2G1B variants
Benign 1
- p.Arg122His Multiple submitters ⚠
Likely benign 1
- c.195-10C>T Single submitter
Uncertain significance 20
- p.Ala115Gly Single submitter ⚠
- p.Ala15Thr Single submitter ⚠
- p.Asn123Ser Single submitter ⚠
- p.Asp121Asn Single submitter ⚠
- p.Asp121Tyr Single submitter ⚠
- p.Asp39Glu Single submitter ⚠
- p.Cys83Arg Single submitter ⚠
- p.Glu112Gly Single submitter ⚠
- p.Gly55Asp Single submitter ⚠
- p.His70Tyr Single submitter ⚠
- p.Lys65Glu Single submitter ⚠
- p.Lys84Glu Single submitter ⚠
- p.Pro90Gln Single submitter ⚠
- p.Ser102Leu Single submitter ⚠
- p.Thr58Asn Single submitter ⚠
- p.Thr58Ile Single submitter ⚠
- p.Thr92Ile Single submitter ⚠
- p.Tyr133Cys Single submitter ⚠
- p.Tyr91Cys Single submitter ⚠
- p.Val5Ala Single submitter ⚠