PLA2G2C — 16 ClinVar variants
All ClinVar germline PLA2G2C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
3 Likely benign · 13 Uncertain significance
Full PLA2G2C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLA2G2C p.Arg60Trp Uncertain significance Single submitter
- PLA2G2C p.Cys142Tyr Uncertain significance Single submitter
- PLA2G2C p.Glu130Ala Uncertain significance Single submitter
- PLA2G2C p.Glu74Gly Uncertain significance Single submitter
- PLA2G2C p.Leu109Pro Uncertain significance Single submitter
- PLA2G2C p.Leu99Phe Uncertain significance Single submitter
- PLA2G2C p.Lys134Gln Uncertain significance Single submitter
- PLA2G2C p.Ser62Arg Uncertain significance Single submitter
- PLA2G2C p.Val94Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All PLA2G2C variants
Likely benign 3
- p.Ala103Val Single submitter
- p.Gly41Arg Single submitter
- p.Ser65Phe Single submitter
Uncertain significance 13
- c.41-15C>T Single submitter
- p.Arg60Trp Single submitter ⚠
- p.Cys142Tyr Single submitter ⚠
- p.Cys46Gly Single submitter ⚠
- p.Glu130Ala Single submitter ⚠
- p.Glu74Gly Single submitter ⚠
- p.Leu109Pro Single submitter ⚠
- p.Leu99Phe Single submitter ⚠
- p.Lys134Gln Single submitter ⚠
- p.Phe122Leu Single submitter ⚠
- p.Phe133Leu Single submitter ⚠
- p.Ser62Arg Single submitter ⚠
- p.Val94Ile Single submitter ⚠