PLA2G3 — 92 ClinVar variants
All ClinVar germline PLA2G3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
14 Likely benign · 78 Uncertain significance
Full PLA2G3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLA2G3 p.Ala252Thr Uncertain significance Single submitter
- PLA2G3 p.Ala341Asp Uncertain significance Single submitter
- PLA2G3 p.Ala388Val Uncertain significance Single submitter
- PLA2G3 p.Ala5Pro Uncertain significance Single submitter
- PLA2G3 p.Ala88Asp Uncertain significance Single submitter
- PLA2G3 p.Arg132Gln Uncertain significance Single submitter
- PLA2G3 p.Arg182Gln Uncertain significance Single submitter
- PLA2G3 p.Arg186Cys Uncertain significance Single submitter
- PLA2G3 p.Arg204Gln Uncertain significance Single submitter
- PLA2G3 p.Arg25Cys Uncertain significance Single submitter
- PLA2G3 p.Arg272Cys Uncertain significance Single submitter
- PLA2G3 p.Arg276Thr Uncertain significance Single submitter
- PLA2G3 p.Arg295Trp Uncertain significance Single submitter
- PLA2G3 p.Arg362His Uncertain significance Single submitter
- PLA2G3 p.Arg365His Uncertain significance Single submitter
- PLA2G3 p.Arg366His Uncertain significance Single submitter
- PLA2G3 p.Arg366Leu Uncertain significance Single submitter
- PLA2G3 p.Arg378Trp Uncertain significance Single submitter
- PLA2G3 p.Arg403His Uncertain significance Single submitter
- PLA2G3 p.Arg403Leu Uncertain significance Single submitter
- PLA2G3 p.Arg452Gln Uncertain significance Single submitter
- PLA2G3 p.Arg452Leu Uncertain significance Single submitter
- PLA2G3 p.Arg455Trp Uncertain significance Single submitter
- PLA2G3 p.Asn325Asp Uncertain significance Single submitter
- PLA2G3 p.Asn415Ser Uncertain significance Single submitter
- PLA2G3 p.Asp470Glu Uncertain significance Single submitter
- PLA2G3 p.Cys180Gly Uncertain significance Single submitter
- PLA2G3 p.Cys262Phe Uncertain significance Single submitter
- PLA2G3 p.Cys262Tyr Uncertain significance Single submitter
- PLA2G3 p.Cys434Gly Uncertain significance Single submitter
- PLA2G3 p.Gln189Lys Uncertain significance Single submitter
- PLA2G3 p.Gln306Arg Uncertain significance Single submitter
- PLA2G3 p.Gln349Arg Uncertain significance Single submitter
- PLA2G3 p.Gln374His Uncertain significance Single submitter
- PLA2G3 p.Gln459Arg Uncertain significance Single submitter
- PLA2G3 p.Glu103Lys Uncertain significance Single submitter
- PLA2G3 p.Glu372Lys Uncertain significance Single submitter
- PLA2G3 p.Glu412Lys Uncertain significance Single submitter
- PLA2G3 p.Glu419Val Uncertain significance Single submitter
- PLA2G3 p.Gly143Val Uncertain significance Single submitter
- PLA2G3 p.Gly311Val Uncertain significance Single submitter
- PLA2G3 p.Gly356Asp Uncertain significance Single submitter
- PLA2G3 p.His59Arg Uncertain significance Single submitter
- PLA2G3 p.Leu104Pro Uncertain significance Single submitter
- PLA2G3 p.Leu157Pro Uncertain significance Single submitter
- PLA2G3 p.Leu329Phe Uncertain significance Single submitter
- PLA2G3 p.Leu384Pro Uncertain significance Single submitter
- PLA2G3 p.Leu464Pro Uncertain significance Single submitter
- PLA2G3 p.Leu48Pro Uncertain significance Single submitter
- PLA2G3 p.Lys130Arg Uncertain significance Single submitter
- PLA2G3 p.Lys50Asn Uncertain significance Single submitter
- PLA2G3 p.Met153Ile Uncertain significance Single submitter
- PLA2G3 p.Met264Arg Uncertain significance Single submitter
- PLA2G3 p.Met264Ile Uncertain significance Single submitter
- PLA2G3 p.Pro302Leu Uncertain significance Single submitter
- PLA2G3 p.Pro348Leu Uncertain significance Single submitter
- PLA2G3 p.Pro430Leu Uncertain significance Single submitter
- PLA2G3 p.Ser168Phe Uncertain significance Single submitter
- PLA2G3 p.Ser229Leu Uncertain significance Single submitter
- PLA2G3 p.Ser296Arg Uncertain significance Single submitter
- PLA2G3 p.Ser387Gly Uncertain significance Single submitter
- PLA2G3 p.Thr29Asn Uncertain significance Single submitter
- PLA2G3 p.Trp475Gly Uncertain significance Single submitter
- PLA2G3 p.Tyr198Cys Uncertain significance Single submitter
- PLA2G3 p.Val232Met Uncertain significance Single submitter
- PLA2G3 p.Val413Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- PLA2G3 p.Ala446Thr Uncertain significance Single submitter
- PLA2G3 p.Arg182Trp Uncertain significance Single submitter
- PLA2G3 p.Arg399Cys Uncertain significance Single submitter
- PLA2G3 p.Asn386Ser Uncertain significance Single submitter
- PLA2G3 p.Cys440Tyr Uncertain significance Single submitter
- PLA2G3 p.Ile375Thr Uncertain significance Single submitter
- PLA2G3 p.Ile58Thr Uncertain significance Single submitter
- PLA2G3 p.Leu392Phe Uncertain significance Single submitter
- PLA2G3 p.Leu491Pro Uncertain significance Single submitter
- PLA2G3 p.Phe364Ser Uncertain significance Single submitter
All PLA2G3 variants
Likely benign 14
- p.Ala328Val Single submitter
- p.Arg186His Single submitter
- p.Arg286Pro Single submitter
- p.Arg286Trp Single submitter
- p.Arg295Gln Single submitter
- p.Arg303Gln Single submitter
- p.Arg320His Single submitter
- p.Arg358His Single submitter
- p.Arg61His Single submitter
- p.Gly6Val Single submitter
- p.Gly84Ser Single submitter
- p.Met333Val Single submitter
- p.Met484Val Single submitter
- p.Pro100= Single submitter
Uncertain significance 78
- p.Ala252Thr Single submitter ⚠
- p.Ala341Asp Single submitter ⚠
- p.Ala388Val Single submitter ⚠
- p.Ala446Thr Single submitter ⚠
- p.Ala5Pro Single submitter ⚠
- p.Ala88Asp Single submitter ⚠
- p.Arg132Gln Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg182Trp Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg25Cys Single submitter ⚠
- p.Arg272Cys Single submitter ⚠
- p.Arg276Thr Single submitter ⚠
- p.Arg295Trp Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg366His Single submitter ⚠
- p.Arg366Leu Single submitter ⚠
- p.Arg378Trp Single submitter ⚠
- p.Arg399Cys Single submitter ⚠
- p.Arg403His Single submitter ⚠
- p.Arg403Leu Single submitter ⚠
- p.Arg452Gln Single submitter ⚠
- p.Arg452Leu Single submitter ⚠
- p.Arg455Trp Single submitter ⚠
- p.Asn325Asp Single submitter ⚠
- p.Asn386Ser Single submitter ⚠
- p.Asn415Ser Single submitter ⚠
- p.Asp470Glu Single submitter ⚠
- p.Cys180Gly Single submitter ⚠
- p.Cys262Phe Single submitter ⚠
- p.Cys262Tyr Single submitter ⚠
- p.Cys434Gly Single submitter ⚠
- p.Cys434Phe Single submitter
- p.Cys440Tyr Single submitter ⚠
- p.Gln189Lys Single submitter ⚠
- p.Gln306Arg Single submitter ⚠
- p.Gln349Arg Single submitter ⚠
- p.Gln374His Single submitter ⚠
- p.Gln459Arg Single submitter ⚠
- p.Glu103Lys Single submitter ⚠
- p.Glu372Lys Single submitter ⚠
- p.Glu412Lys Single submitter ⚠
- p.Glu419Val Single submitter ⚠
- p.Gly143Val Single submitter ⚠
- p.Gly311Val Single submitter ⚠
- p.Gly356Asp Single submitter ⚠
- p.His59Arg Single submitter ⚠
- p.Ile375Thr Single submitter ⚠
- p.Ile58Thr Single submitter ⚠
- p.Leu104Pro Single submitter ⚠
- p.Leu157Pro Single submitter ⚠
- p.Leu329Phe Single submitter ⚠
- p.Leu384Pro Single submitter ⚠
- p.Leu392Phe Single submitter ⚠
- p.Leu464Pro Single submitter ⚠
- p.Leu48Pro Single submitter ⚠
- p.Leu491Pro Single submitter ⚠
- p.Lys130Arg Single submitter ⚠
- p.Lys50Asn Single submitter ⚠
- p.Met153Ile Single submitter ⚠
- p.Met264Arg Single submitter ⚠
- p.Met264Ile Single submitter ⚠
- p.Phe364Ser Single submitter ⚠
- p.Pro302Leu Single submitter ⚠
- p.Pro348Leu Single submitter ⚠
- p.Pro430Leu Single submitter ⚠
- p.Ser168Phe Single submitter ⚠
- p.Ser229Leu Single submitter ⚠
- p.Ser296Arg Single submitter ⚠
- p.Ser387Gly Single submitter ⚠
- p.Thr29Asn Single submitter ⚠
- p.Trp475Gly Single submitter ⚠
- p.Tyr198Cys Single submitter ⚠
- p.Val232Met Single submitter ⚠
- p.Val413Ile Single submitter ⚠
- c.782+1G>C No assertion criteria essential tremor