PLA2G4C — 108 ClinVar variants
All ClinVar germline PLA2G4C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 99 flagged for review →
4 Benign · 5 Likely benign · 99 Uncertain significance
Full PLA2G4C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 99
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 73
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLA2G4C p.Ala139Val Uncertain significance Single submitter
- PLA2G4C p.Ala204Val Uncertain significance Single submitter
- PLA2G4C p.Ala207Thr Uncertain significance Single submitter
- PLA2G4C p.Ala352Thr Uncertain significance Single submitter
- PLA2G4C p.Ala451Thr Uncertain significance Single submitter
- PLA2G4C p.Ala474Ser Uncertain significance Single submitter
- PLA2G4C p.Ala481Glu Uncertain significance Single submitter
- PLA2G4C p.Ala541Thr Uncertain significance Single submitter
- PLA2G4C p.Arg108Gln Uncertain significance Single submitter
- PLA2G4C p.Arg222Thr Uncertain significance Single submitter
- PLA2G4C p.Arg22Ser Uncertain significance Single submitter
- PLA2G4C p.Arg267Lys Uncertain significance Single submitter
- PLA2G4C p.Arg283Gln Uncertain significance Single submitter
- PLA2G4C p.Arg283Leu Uncertain significance Single submitter
- PLA2G4C p.Arg319Gly Uncertain significance Single submitter
- PLA2G4C p.Arg422Gln Uncertain significance Single submitter
- PLA2G4C p.Arg429Cys Uncertain significance Single submitter
- PLA2G4C p.Arg429His Uncertain significance Single submitter
- PLA2G4C p.Arg430His Uncertain significance Single submitter
- PLA2G4C p.Asn157His Uncertain significance Single submitter
- PLA2G4C p.Asn94Ser Uncertain significance Single submitter
- PLA2G4C p.Asp487Asn Uncertain significance Single submitter
- PLA2G4C p.Glu113Lys Uncertain significance Single submitter
- PLA2G4C p.Glu152Lys Uncertain significance Single submitter
- PLA2G4C p.Glu194Lys Uncertain significance Single submitter
- PLA2G4C p.Glu289Gly Uncertain significance Single submitter
- PLA2G4C p.Glu289Val Uncertain significance Single submitter
- PLA2G4C p.Glu315Lys Uncertain significance Single submitter
- PLA2G4C p.Glu440Lys Uncertain significance Single submitter
- PLA2G4C p.Glu480Asp Uncertain significance Single submitter
- PLA2G4C p.Glu5Ala Uncertain significance Single submitter
- PLA2G4C p.Glu99Gln Uncertain significance Single submitter
- PLA2G4C p.Gly215Arg Uncertain significance Single submitter
- PLA2G4C p.Gly277Glu Uncertain significance Single submitter
- PLA2G4C p.Gly302Ser Uncertain significance Single submitter
- PLA2G4C p.Gly303Ser Uncertain significance Single submitter
- PLA2G4C p.Gly415Arg Uncertain significance Single submitter
- PLA2G4C p.Gly48Cys Uncertain significance Single submitter
- PLA2G4C p.Gly50Arg Uncertain significance Single submitter
- PLA2G4C p.Gly51Arg Uncertain significance Single submitter
- PLA2G4C p.Gly527Arg Uncertain significance Single submitter
- PLA2G4C p.Gly83Glu Uncertain significance Single submitter
- PLA2G4C p.His213Arg Uncertain significance Single submitter
- PLA2G4C p.His213Tyr Uncertain significance Single submitter
- PLA2G4C p.Ile276Thr Uncertain significance Single submitter
- PLA2G4C p.Ile88Val Uncertain significance Single submitter
- PLA2G4C p.Ile8Val Uncertain significance Single submitter
- PLA2G4C p.Leu205Arg Uncertain significance Single submitter
- PLA2G4C p.Leu504Val Uncertain significance Single submitter
- PLA2G4C p.Lys159Glu Uncertain significance Single submitter
- PLA2G4C p.Lys274Glu Uncertain significance Single submitter
- PLA2G4C p.Lys354Asn Uncertain significance Single submitter
- PLA2G4C p.Lys373Asn Uncertain significance Single submitter
- PLA2G4C p.Lys509Asn Uncertain significance Single submitter
- PLA2G4C p.Met98Thr Uncertain significance Single submitter
- PLA2G4C p.Pro170Leu Uncertain significance Single submitter
- PLA2G4C p.Pro181Arg Uncertain significance Single submitter
- PLA2G4C p.Pro181His Uncertain significance Single submitter
- PLA2G4C p.Pro197Leu Uncertain significance Single submitter
- PLA2G4C p.Pro297Ser Uncertain significance Single submitter
- PLA2G4C p.Pro400Leu Uncertain significance Single submitter
- PLA2G4C p.Pro531Leu Uncertain significance Single submitter
- PLA2G4C p.Ser203Cys Uncertain significance Single submitter
- PLA2G4C p.Ser275Arg Uncertain significance Single submitter
- PLA2G4C p.Ser339Gly Uncertain significance Single submitter
- PLA2G4C p.Ser452Gly Uncertain significance Single submitter
- PLA2G4C p.Thr360Ile Uncertain significance Single submitter
- PLA2G4C p.Thr76Met Uncertain significance Single submitter
- PLA2G4C p.Val270Ala Uncertain significance Single submitter
- PLA2G4C p.Val270Phe Uncertain significance Single submitter
- PLA2G4C p.Val499Met Uncertain significance Single submitter
- PLA2G4C p.Val511Ile Uncertain significance Single submitter
- PLA2G4C p.Val75Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- PLA2G4C p.Asp411Asn Benign Multiple submitters
- PLA2G4C p.Ala526Asp Uncertain significance Single submitter
- PLA2G4C p.Ala74Asp Uncertain significance Single submitter
- PLA2G4C p.Arg23Gln Uncertain significance Single submitter
- PLA2G4C p.Arg378Trp Uncertain significance Single submitter
- PLA2G4C p.Arg402Gln Uncertain significance Single submitter
- PLA2G4C p.Arg54Gln Uncertain significance Single submitter
- PLA2G4C p.Arg54Trp Uncertain significance Single submitter
- PLA2G4C p.Asn391Ser Uncertain significance Single submitter
- PLA2G4C p.Asn471Asp Uncertain significance Single submitter
- PLA2G4C p.Asn514Asp Uncertain significance Single submitter
- PLA2G4C p.Cys351Tyr Uncertain significance Single submitter
- PLA2G4C p.Glu16Gln Uncertain significance Single submitter
- PLA2G4C p.Gly387Ala Uncertain significance Single submitter
- PLA2G4C p.Gly387Ser Uncertain significance Single submitter
- PLA2G4C p.His382Gln Uncertain significance Single submitter
- PLA2G4C p.His56Pro Uncertain significance Single submitter
- PLA2G4C p.Ile88Thr Uncertain significance Single submitter
- PLA2G4C p.Leu443Pro Uncertain significance Single submitter
- PLA2G4C p.Met465Ile Uncertain significance Single submitter
- PLA2G4C p.Phe214Leu Uncertain significance Single submitter
- PLA2G4C p.Pro434Leu Uncertain significance Single submitter
- PLA2G4C p.Thr359Ile Uncertain significance Single submitter
- PLA2G4C p.Thr488Ile Uncertain significance Single submitter
- PLA2G4C p.Val397Met Uncertain significance Single submitter
- PLA2G4C p.Val62Phe Uncertain significance Single submitter
All PLA2G4C variants
Benign 4
- p.Asn316= Multiple submitters
- p.Asp411Asn Multiple submitters ⚠
- p.Pro161Ala Multiple submitters
- p.Ser133= Multiple submitters
Likely benign 5
- p.Ala18Val Single submitter
- p.Asn340Asp Single submitter
- p.Ile472Thr Single submitter
- p.Lys106Arg Single submitter
- p.Pro10Leu No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 99
- p.Ala139Val Single submitter ⚠
- p.Ala204Val Single submitter ⚠
- p.Ala207Thr Single submitter ⚠
- p.Ala352Thr Single submitter ⚠
- p.Ala451Thr Single submitter ⚠
- p.Ala474Ser Single submitter ⚠
- p.Ala481Glu Single submitter ⚠
- p.Ala526Asp Single submitter ⚠
- p.Ala541Thr Single submitter ⚠
- p.Ala74Asp Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg222Thr Single submitter ⚠
- p.Arg22Ser Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg267Lys Single submitter ⚠
- p.Arg283Gln Single submitter ⚠
- p.Arg283Leu Single submitter ⚠
- p.Arg319Gly Single submitter ⚠
- p.Arg378Trp Single submitter ⚠
- p.Arg402Gln Single submitter ⚠
- p.Arg422Gln Single submitter ⚠
- p.Arg429Cys Single submitter ⚠
- p.Arg429His Single submitter ⚠
- p.Arg430His Single submitter ⚠
- p.Arg54Gln Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Asn157His Single submitter ⚠
- p.Asn391Ser Single submitter ⚠
- p.Asn471Asp Single submitter ⚠
- p.Asn514Asp Single submitter ⚠
- p.Asn94Ser Single submitter ⚠
- p.Asp487Asn Single submitter ⚠
- p.Cys351Tyr Single submitter ⚠
- p.Glu113Lys Single submitter ⚠
- p.Glu152Lys Single submitter ⚠
- p.Glu16Gln Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu289Gly Single submitter ⚠
- p.Glu289Val Single submitter ⚠
- p.Glu315Lys Single submitter ⚠
- p.Glu440Lys Single submitter ⚠
- p.Glu480Asp Single submitter ⚠
- p.Glu5Ala Single submitter ⚠
- p.Glu99Gln Single submitter ⚠
- p.Gly215Arg Single submitter ⚠
- p.Gly277Glu Single submitter ⚠
- p.Gly302Ser Single submitter ⚠
- p.Gly303Ser Single submitter ⚠
- p.Gly387Ala Single submitter ⚠
- p.Gly387Ser Single submitter ⚠
- p.Gly415Arg Single submitter ⚠
- p.Gly48Cys Single submitter ⚠
- p.Gly50Arg Single submitter ⚠
- p.Gly51Arg Single submitter ⚠
- p.Gly527Arg Single submitter ⚠
- p.Gly83Glu Single submitter ⚠
- p.His213Arg Single submitter ⚠
- p.His213Tyr Single submitter ⚠
- p.His382Gln Single submitter ⚠
- p.His56Pro Single submitter ⚠
- p.Ile276Thr Single submitter ⚠
- p.Ile88Thr Single submitter ⚠
- p.Ile88Val Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu205Arg Single submitter ⚠
- p.Leu443Pro Single submitter ⚠
- p.Leu504Val Single submitter ⚠
- p.Lys159Glu Single submitter ⚠
- p.Lys274Glu Single submitter ⚠
- p.Lys354Asn Single submitter ⚠
- p.Lys373Asn Single submitter ⚠
- p.Lys509Asn Single submitter ⚠
- p.Met465Ile Single submitter ⚠
- p.Met98Thr Single submitter ⚠
- p.Phe214Leu Single submitter ⚠
- p.Pro170Leu Single submitter ⚠
- p.Pro181Arg Single submitter ⚠
- p.Pro181His Single submitter ⚠
- p.Pro197Leu Single submitter ⚠
- p.Pro297Ser Single submitter ⚠
- p.Pro400Leu Single submitter ⚠
- p.Pro434Leu Single submitter ⚠
- p.Pro531Leu Single submitter ⚠
- p.Ser203Cys Single submitter ⚠
- p.Ser275Arg Single submitter ⚠
- p.Ser339Gly Single submitter ⚠
- p.Ser452Gly Single submitter ⚠
- p.Ser84Thr Single submitter
- p.Thr359Ile Single submitter ⚠
- p.Thr360Ile Single submitter ⚠
- p.Thr488Ile Single submitter ⚠
- p.Thr76Met Single submitter ⚠
- p.Val270Ala Single submitter ⚠
- p.Val270Phe Single submitter ⚠
- p.Val397Met Single submitter ⚠
- p.Val499Met Single submitter ⚠
- p.Val511Ile Single submitter ⚠
- p.Val62Phe Single submitter ⚠
- p.Val75Ile Single submitter ⚠