PLA2R1 — 198 ClinVar variants
All ClinVar germline PLA2R1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 170 flagged for review →
5 Benign · 21 Likely benign · 172 Uncertain significance
Full PLA2R1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 170
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 158
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 158
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PLA2R1 p.Pro29Arg
Uncertain significance
Multiple submitters
kidney disorder
- PLA2R1 p.Ala1000Thr Uncertain significance Single submitter
- PLA2R1 p.Ala1068Thr Uncertain significance Single submitter
- PLA2R1 p.Ala1212Val Uncertain significance Single submitter
- PLA2R1 p.Ala133Val Uncertain significance Single submitter
- PLA2R1 p.Ala1388Val Uncertain significance Single submitter
- PLA2R1 p.Ala301Thr Uncertain significance Single submitter
- PLA2R1 p.Ala340Pro Uncertain significance Single submitter
- PLA2R1 p.Ala340Val Uncertain significance Single submitter
- PLA2R1 p.Ala434Thr Uncertain significance Single submitter
- PLA2R1 p.Ala653Ser Uncertain significance Single submitter
- PLA2R1 p.Ala822Gly Uncertain significance Single submitter
- PLA2R1 p.Ala882Val Uncertain significance Single submitter
- PLA2R1 p.Arg1167Gln Uncertain significance Single submitter
- PLA2R1 p.Arg17Pro Uncertain significance Single submitter
- PLA2R1 p.Arg194Cys Uncertain significance Single submitter
- PLA2R1 p.Arg194His Uncertain significance Single submitter
- PLA2R1 p.Arg209Cys Uncertain significance Single submitter
- PLA2R1 p.Arg344Gln Uncertain significance Single submitter
- PLA2R1 p.Arg344Trp Uncertain significance Single submitter
- PLA2R1 p.Arg474Gly Uncertain significance Single submitter
- PLA2R1 p.Arg534Gln Uncertain significance Single submitter
- PLA2R1 p.Arg621Gln Uncertain significance Single submitter
- PLA2R1 p.Arg628His Uncertain significance Single submitter
- PLA2R1 p.Arg628Leu Uncertain significance Single submitter
- PLA2R1 p.Arg635Trp Uncertain significance Single submitter
- PLA2R1 p.Arg693Ile Uncertain significance Single submitter
- PLA2R1 p.Arg792Cys Uncertain significance Single submitter
- PLA2R1 p.Arg792His Uncertain significance Single submitter
- PLA2R1 p.Asn1013Tyr Uncertain significance Single submitter
- PLA2R1 p.Asn1181Ser Uncertain significance Single submitter
- PLA2R1 p.Asn1316Ser Uncertain significance Single submitter
- PLA2R1 p.Asn277Ser Uncertain significance Single submitter
- PLA2R1 p.Asn295Ser Uncertain significance Single submitter
- PLA2R1 p.Asn444Asp Uncertain significance Single submitter
- PLA2R1 p.Asn492Lys Uncertain significance Single submitter
- PLA2R1 p.Asn584Ser Uncertain significance Single submitter
- PLA2R1 p.Asn607Ser Uncertain significance Single submitter
- PLA2R1 p.Asn649Tyr Uncertain significance Single submitter
- PLA2R1 p.Asn745Thr Uncertain significance Single submitter
- PLA2R1 p.Asn883Ser Uncertain significance Single submitter
- PLA2R1 p.Asp1457Asn Uncertain significance Single submitter
- PLA2R1 p.Asp298Ala Uncertain significance Single submitter
- PLA2R1 p.Asp585Val Uncertain significance Single submitter
- PLA2R1 p.Asp753Gly Uncertain significance Single submitter
- PLA2R1 p.Asp813Gly Uncertain significance Single submitter
- PLA2R1 p.Asp821Asn Uncertain significance Single submitter
- PLA2R1 p.Asp884Gly Uncertain significance Single submitter
- PLA2R1 p.Cys1414Gly Uncertain significance Single submitter
- PLA2R1 p.Cys242Tyr Uncertain significance Single submitter
- PLA2R1 p.Cys330Arg Uncertain significance Single submitter
-
PLA2R1 p.Cys699Tyr
Uncertain significance
Single submitter
kidney disorder
- PLA2R1 p.Gln187Arg Uncertain significance Single submitter
- PLA2R1 p.Gln954Arg Uncertain significance Single submitter
- PLA2R1 p.Glu1224Lys Uncertain significance Single submitter
- PLA2R1 p.Glu379Lys Uncertain significance Single submitter
- PLA2R1 p.Glu520Lys Uncertain significance Single submitter
- PLA2R1 p.Glu599Gly Uncertain significance Single submitter
- PLA2R1 p.Glu885Gly Uncertain significance Single submitter
- PLA2R1 p.Glu994Ala Uncertain significance Single submitter
- PLA2R1 p.Gly1091Asp Uncertain significance Single submitter
- PLA2R1 p.Gly1091Ser Uncertain significance Single submitter
- PLA2R1 p.Gly1207Ser Uncertain significance Single submitter
- PLA2R1 p.Gly1340Val Uncertain significance Single submitter
- PLA2R1 p.Gly155Ala Uncertain significance Single submitter
- PLA2R1 p.Gly381Asp Uncertain significance Single submitter
- PLA2R1 p.Gly789Ser Uncertain significance Single submitter
- PLA2R1 p.Gly86Arg Uncertain significance Single submitter
- PLA2R1 p.Gly915Ser Uncertain significance Single submitter
- PLA2R1 p.His134Tyr Uncertain significance Single submitter
- PLA2R1 p.His1352Tyr Uncertain significance Single submitter
- PLA2R1 p.His1384Asp Uncertain significance Single submitter
- PLA2R1 p.His189Arg Uncertain significance Single submitter
- PLA2R1 p.His282Tyr Uncertain significance Single submitter
- PLA2R1 p.His469Arg Uncertain significance Single submitter
- PLA2R1 p.His506Tyr Uncertain significance Single submitter
- PLA2R1 p.His662Tyr Uncertain significance Single submitter
- PLA2R1 p.His723Arg Uncertain significance Single submitter
- PLA2R1 p.Ile1023Val Uncertain significance Single submitter
- PLA2R1 p.Ile1252Val Uncertain significance Single submitter
- PLA2R1 p.Ile1326Leu Uncertain significance Single submitter
- PLA2R1 p.Ile1326Thr Uncertain significance Single submitter
- PLA2R1 p.Ile1326Val Uncertain significance Single submitter
- PLA2R1 p.Ile1383Ser Uncertain significance Single submitter
- PLA2R1 p.Ile149Thr Uncertain significance Single submitter
- PLA2R1 p.Ile169Met Uncertain significance Single submitter
- PLA2R1 p.Ile500Val Uncertain significance Single submitter
- PLA2R1 p.Ile736Leu Uncertain significance Single submitter
- PLA2R1 p.Leu358Pro Uncertain significance Single submitter
- PLA2R1 p.Leu466Pro Uncertain significance Single submitter
- PLA2R1 p.Leu923Phe Uncertain significance Single submitter
- PLA2R1 p.Lys1037Asn Uncertain significance Single submitter
- PLA2R1 p.Lys1089Glu Uncertain significance Single submitter
- PLA2R1 p.Lys1146Glu Uncertain significance Single submitter
- PLA2R1 p.Lys147Glu Uncertain significance Single submitter
- PLA2R1 p.Lys38Glu Uncertain significance Single submitter
- PLA2R1 p.Lys445Glu Uncertain significance Single submitter
- PLA2R1 p.Lys638Arg Uncertain significance Single submitter
- PLA2R1 p.Lys940Arg Uncertain significance Single submitter
- PLA2R1 p.Lys940Glu Uncertain significance Single submitter
- PLA2R1 p.Met1112Ile Uncertain significance Single submitter
- PLA2R1 p.Met1115Val Uncertain significance Single submitter
- PLA2R1 p.Met1144Ile Uncertain significance Single submitter
- PLA2R1 p.Met121Val Uncertain significance Single submitter
- PLA2R1 p.Met292Thr Uncertain significance Single submitter
- PLA2R1 p.Met688Ile Uncertain significance Single submitter
- PLA2R1 p.Met933Val Uncertain significance Single submitter
- PLA2R1 p.Phe726Ile Uncertain significance Single submitter
- PLA2R1 p.Pro1368Arg Uncertain significance Single submitter
- PLA2R1 p.Pro1368Leu Uncertain significance Single submitter
- PLA2R1 p.Pro1440Thr Uncertain significance Single submitter
- PLA2R1 p.Pro29Leu Uncertain significance Single submitter
- PLA2R1 p.Pro318Ala Uncertain significance Single submitter
- PLA2R1 p.Pro338Ala Uncertain significance Single submitter
- PLA2R1 p.Pro5Arg Uncertain significance Single submitter
- PLA2R1 p.Pro600Gln Uncertain significance Single submitter
- PLA2R1 p.Pro600Leu Uncertain significance Single submitter
- PLA2R1 p.Pro663Arg Uncertain significance Single submitter
- PLA2R1 p.Pro978Thr Uncertain significance Single submitter
- PLA2R1 p.Ser1110Ala Uncertain significance Single submitter
- PLA2R1 p.Ser1151Asn Uncertain significance Single submitter
- PLA2R1 p.Ser1204Phe Uncertain significance Single submitter
- PLA2R1 p.Ser1461Thr Uncertain significance Single submitter
- PLA2R1 p.Ser150Pro Uncertain significance Single submitter
- PLA2R1 p.Ser249Leu Uncertain significance Single submitter
- PLA2R1 p.Ser285Arg Uncertain significance Single submitter
- PLA2R1 p.Ser343Asn Uncertain significance Single submitter
- PLA2R1 p.Ser760Leu Uncertain significance Single submitter
- PLA2R1 p.Ser831Leu Uncertain significance Single submitter
- PLA2R1 p.Ser926Thr Uncertain significance Single submitter
- PLA2R1 p.Ser979Asn Uncertain significance Single submitter
- PLA2R1 p.Thr1057Ile Uncertain significance Single submitter
- PLA2R1 p.Thr1134Ser Uncertain significance Single submitter
- PLA2R1 p.Thr1266Ile Uncertain significance Single submitter
- PLA2R1 p.Thr1346Ala Uncertain significance Single submitter
- PLA2R1 p.Thr1415Ala Uncertain significance Single submitter
- PLA2R1 p.Thr28Ala Uncertain significance Single submitter
- PLA2R1 p.Thr309Met Uncertain significance Single submitter
- PLA2R1 p.Thr417Asn Uncertain significance Single submitter
- PLA2R1 p.Thr465Ile Uncertain significance Single submitter
- PLA2R1 p.Thr691Ile Uncertain significance Single submitter
- PLA2R1 p.Thr957Met Uncertain significance Single submitter
- PLA2R1 p.Thr985Lys Uncertain significance Single submitter
- PLA2R1 p.Trp115Arg Uncertain significance Single submitter
- PLA2R1 p.Trp488Cys Uncertain significance Single submitter
- PLA2R1 p.Trp519Arg Uncertain significance Single submitter
- PLA2R1 p.Tyr1421Cys Uncertain significance Single submitter
- PLA2R1 p.Tyr161Cys Uncertain significance Single submitter
- PLA2R1 p.Tyr373His Uncertain significance Single submitter
- PLA2R1 p.Tyr869Cys Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- PLA2R1 p.Arg628Cys Uncertain significance Single submitter
- PLA2R1 p.Asp199Val Uncertain significance Single submitter
- PLA2R1 p.Gly175Arg Uncertain significance Single submitter
- PLA2R1 p.Gly995Ala Likely benign Single submitter
- PLA2R1 p.His605Pro Likely benign Single submitter
- PLA2R1 p.Ile1001Thr Uncertain significance Single submitter
- PLA2R1 p.Ile1128Thr Uncertain significance Single submitter
- PLA2R1 p.Ile439Thr Uncertain significance Single submitter
- PLA2R1 p.Ser1204Cys Uncertain significance Single submitter
- PLA2R1 p.Ser405Pro Uncertain significance Single submitter
- PLA2R1 p.Ser47Cys Uncertain significance Single submitter
- PLA2R1 p.Thr193Ile Uncertain significance Single submitter
All PLA2R1 variants
Benign 5
- p.Ala653fs Single submitter kidney disorder
- p.Gly1106Ser Single submitter atypical hemolytic-uremic syndrome
- p.His300Asp Single submitter atypical hemolytic-uremic syndrome
- p.Lys652Asn Single submitter kidney disorder
- p.Met292Val Single submitter atypical hemolytic-uremic syndrome
Likely benign 21
- p.Leu294= Multiple submitters
- c.-127del Single submitter kidney disorder
- p.Ala1000Ser Single submitter
- p.Ala370= Single submitter
- p.Ala408Ser Single submitter
- p.Ala412Thr Single submitter
- p.Arg116His Single submitter
- p.Arg1217His Single submitter
- p.Arg142Gln Single submitter kidney disorder
- p.Arg1435Gln Single submitter
- p.Asn1215= Single submitter
- p.Asp272= Single submitter kidney disorder
- p.Glu1201Asp Single submitter
- p.Glu1242Gly Single submitter
- p.Gly995Ala Single submitter ⚠
- p.His1105Arg Single submitter
- p.His605Pro Single submitter ⚠
- p.Ile232Val Single submitter
- p.Ser1003Asn Single submitter
- p.Ser1054Asn Single submitter
- p.Val111Ile Single submitter
Uncertain significance 172
- p.Pro29Arg Multiple submitters kidney disorder ⚠
- p.Ala1000Thr Single submitter ⚠
- p.Ala1068Thr Single submitter ⚠
- p.Ala1212Val Single submitter ⚠
- p.Ala133Val Single submitter ⚠
- p.Ala1388Val Single submitter ⚠
- p.Ala1402Glu Single submitter
- p.Ala301Thr Single submitter ⚠
- p.Ala340Pro Single submitter ⚠
- p.Ala340Val Single submitter ⚠
- p.Ala434Thr Single submitter ⚠
- p.Ala653Ser Single submitter ⚠
- p.Ala822Gly Single submitter ⚠
- p.Ala882Val Single submitter ⚠
- p.Arg1167Gln Single submitter ⚠
- p.Arg17Pro Single submitter ⚠
- p.Arg194Cys Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg344Gln Single submitter ⚠
- p.Arg344Trp Single submitter ⚠
- p.Arg474Gly Single submitter ⚠
- p.Arg534Gln Single submitter ⚠
- p.Arg621Gln Single submitter ⚠
- p.Arg628Cys Single submitter ⚠
- p.Arg628His Single submitter ⚠
- p.Arg628Leu Single submitter ⚠
- p.Arg635Trp Single submitter ⚠
- p.Arg693Ile Single submitter ⚠
- p.Arg792Cys Single submitter ⚠
- p.Arg792His Single submitter ⚠
- p.Asn1013Tyr Single submitter ⚠
- p.Asn1181Ser Single submitter ⚠
- p.Asn1286fs Single submitter kidney disorder
- p.Asn1316Ser Single submitter ⚠
- p.Asn277Ser Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asn444Asp Single submitter ⚠
- p.Asn492Lys Single submitter ⚠
- p.Asn584Ser Single submitter ⚠
- p.Asn607Ser Single submitter ⚠
- p.Asn649Tyr Single submitter ⚠
- p.Asn745Thr Single submitter ⚠
- p.Asn883Ser Single submitter ⚠
- p.Asp1457Asn Single submitter ⚠
- p.Asp199Val Single submitter ⚠
- p.Asp298Ala Single submitter ⚠
- p.Asp585Val Single submitter ⚠
- p.Asp753Gly Single submitter ⚠
- p.Asp813Gly Single submitter ⚠
- p.Asp821Asn Single submitter ⚠
- p.Asp884Gly Single submitter ⚠
- p.Cys1414Gly Single submitter ⚠
- p.Cys242Tyr Single submitter ⚠
- p.Cys330Arg Single submitter ⚠
- p.Cys699Tyr Single submitter kidney disorder ⚠
- p.Gln187Arg Single submitter ⚠
- p.Gln954Arg Single submitter ⚠
- p.Glu1224Lys Single submitter ⚠
- p.Glu379Lys Single submitter ⚠
- p.Glu520Lys Single submitter ⚠
- p.Glu599Gly Single submitter ⚠
- p.Glu885Gly Single submitter ⚠
- p.Glu994Ala Single submitter ⚠
- p.Gly1091Asp Single submitter ⚠
- p.Gly1091Ser Single submitter ⚠
- p.Gly1190= Single submitter kidney disorder
- p.Gly1207Ser Single submitter ⚠
- p.Gly1340Val Single submitter ⚠
- p.Gly155Ala Single submitter ⚠
- p.Gly175Arg Single submitter ⚠
- p.Gly381Asp Single submitter ⚠
- p.Gly789Ser Single submitter ⚠
- p.Gly86Arg Single submitter ⚠
- p.Gly915Ser Single submitter ⚠
- p.His134Tyr Single submitter ⚠
- p.His1352Tyr Single submitter ⚠
- p.His1384Asp Single submitter ⚠
- p.His189Arg Single submitter ⚠
- p.His282Tyr Single submitter ⚠
- p.His469Arg Single submitter ⚠
- p.His506Tyr Single submitter ⚠
- p.His662Tyr Single submitter ⚠
- p.His723Arg Single submitter ⚠
- p.Ile1001Thr Single submitter ⚠
- p.Ile1023Val Single submitter ⚠
- p.Ile1128Thr Single submitter ⚠
- p.Ile1252Val Single submitter ⚠
- p.Ile1326Leu Single submitter ⚠
- p.Ile1326Thr Single submitter ⚠
- p.Ile1326Val Single submitter ⚠
- p.Ile1383Ser Single submitter ⚠
- p.Ile149Thr Single submitter ⚠
- p.Ile169Met Single submitter ⚠
- p.Ile439Thr Single submitter ⚠
- p.Ile500Val Single submitter ⚠
- p.Ile736Leu Single submitter ⚠
- p.Leu358Pro Single submitter ⚠
- p.Leu466Pro Single submitter ⚠
- p.Leu923Phe Single submitter ⚠
- p.Lys1037Asn Single submitter ⚠
- p.Lys1089Glu Single submitter ⚠
- p.Lys1146Glu Single submitter ⚠
- p.Lys147Glu Single submitter ⚠
- p.Lys38Glu Single submitter ⚠
- p.Lys445Glu Single submitter ⚠
- p.Lys638Arg Single submitter ⚠
- p.Lys940Arg Single submitter ⚠
- p.Lys940Glu Single submitter ⚠
- p.Met1112Ile Single submitter ⚠
- p.Met1115Val Single submitter ⚠
- p.Met1144Ile Single submitter ⚠
- p.Met121Val Single submitter ⚠
- p.Met292Thr Single submitter ⚠
- p.Met688Ile Single submitter ⚠
- p.Met933Val Single submitter ⚠
- p.Phe278Ser Single submitter
- p.Phe726Ile Single submitter ⚠
- p.Pro1368Arg Single submitter ⚠
- p.Pro1368Leu Single submitter ⚠
- p.Pro1440Thr Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Pro318Ala Single submitter ⚠
- p.Pro338Ala Single submitter ⚠
- p.Pro5Arg Single submitter ⚠
- p.Pro600Gln Single submitter ⚠
- p.Pro600Leu Single submitter ⚠
- p.Pro663Arg Single submitter ⚠
- p.Pro978Thr Single submitter ⚠
- p.Ser1110Ala Single submitter ⚠
- p.Ser1151Asn Single submitter ⚠
- p.Ser1204Cys Single submitter ⚠
- p.Ser1204Phe Single submitter ⚠
- p.Ser1461Thr Single submitter ⚠
- p.Ser150Pro Single submitter ⚠
- p.Ser249Leu Single submitter ⚠
- p.Ser285Arg Single submitter ⚠
- p.Ser343Asn Single submitter ⚠
- p.Ser405Pro Single submitter ⚠
- p.Ser47Cys Single submitter ⚠
- p.Ser760Leu Single submitter ⚠
- p.Ser831Leu Single submitter ⚠
- p.Ser926Thr Single submitter ⚠
- p.Ser979Asn Single submitter ⚠
- p.Thr1057Ile Single submitter ⚠
- p.Thr1134Ser Single submitter ⚠
- p.Thr1266Ile Single submitter ⚠
- p.Thr1346Ala Single submitter ⚠
- p.Thr1415Ala Single submitter ⚠
- p.Thr193Ile Single submitter ⚠
- p.Thr28Ala Single submitter ⚠
- p.Thr309Met Single submitter ⚠
- p.Thr417Asn Single submitter ⚠
- p.Thr465Ile Single submitter ⚠
- p.Thr691Ile Single submitter ⚠
- p.Thr957Met Single submitter ⚠
- p.Thr985Lys Single submitter ⚠
- p.Trp115Arg Single submitter ⚠
- p.Trp488Cys Single submitter ⚠
- p.Trp519Arg Single submitter ⚠
- p.Tyr1421Cys Single submitter ⚠
- p.Tyr161Cys Single submitter ⚠
- p.Tyr373His Single submitter ⚠
- p.Tyr869Cys Single submitter ⚠
- p.Tyr964Cys Single submitter ⚠
- p.Val1060Ile Single submitter ⚠
- p.Val1210Ile Single submitter ⚠
- p.Val458Leu Single submitter ⚠
- p.Val532Ile Single submitter ⚠
- p.Val757Phe Single submitter ⚠
- p.Val802Met Single submitter ⚠
- p.Val999Ala Single submitter ⚠