PLAUR — 64 ClinVar variants
All ClinVar germline PLAUR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
1 Benign · 1 Benign/Likely benign · 10 Likely benign · 52 Uncertain significance
Full PLAUR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLAUR p.Ala106Asp Uncertain significance Single submitter
- PLAUR p.Arg113His Uncertain significance Single submitter
- PLAUR p.Arg131Gly Uncertain significance Single submitter
- PLAUR p.Arg164Cys Uncertain significance Single submitter
- PLAUR p.Arg52Leu Uncertain significance Single submitter
- PLAUR p.Asn102Lys Uncertain significance Single submitter
- PLAUR p.Asn212Ser Uncertain significance Single submitter
- PLAUR p.Cys127Ser Uncertain significance Single submitter
- PLAUR p.Cys137Gly Uncertain significance Single submitter
- PLAUR p.Cys137Tyr Uncertain significance Single submitter
- PLAUR p.Cys28Tyr Uncertain significance Single submitter
- PLAUR p.Cys39Gly Uncertain significance Single submitter
- PLAUR p.Cys93Tyr Uncertain significance Single submitter
- PLAUR p.Glu200Lys Uncertain significance Single submitter
- PLAUR p.Glu230Gly Uncertain significance Single submitter
- PLAUR p.Glu56Val Uncertain significance Single submitter
- PLAUR p.Glu59Gly Uncertain significance Single submitter
- PLAUR p.Glu59Val Uncertain significance Single submitter
- PLAUR p.Glu61Asp Uncertain significance Single submitter
- PLAUR p.Glu90Gly Uncertain significance Single submitter
- PLAUR p.Gly170Asp Uncertain significance Single submitter
- PLAUR p.Gly239Ala Uncertain significance Single submitter
- PLAUR p.Gly239Val Uncertain significance Single submitter
- PLAUR p.Gly311Arg Uncertain significance Single submitter
- PLAUR p.Gly330Val Uncertain significance Single submitter
- PLAUR p.Gly82Ala Uncertain significance Single submitter
- PLAUR p.Ile283Thr Uncertain significance Single submitter
- PLAUR p.Ile85Val Uncertain significance Single submitter
- PLAUR p.Leu204Pro Uncertain significance Single submitter
- PLAUR p.Leu317Ile Uncertain significance Single submitter
- PLAUR p.Leu41Val Uncertain significance Single submitter
- PLAUR p.Met241Thr Uncertain significance Single submitter
- PLAUR p.Pro176Leu Uncertain significance Single submitter
- PLAUR p.Pro308Ser Uncertain significance Single submitter
- PLAUR p.Pro312His Uncertain significance Single submitter
- PLAUR p.Ser123Pro Uncertain significance Single submitter
- PLAUR p.Ser139Arg Uncertain significance Single submitter
- PLAUR p.Ser304Ile Uncertain significance Single submitter
- PLAUR p.Thr73Asn Uncertain significance Single submitter
- PLAUR p.Val91Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- PLAUR p.Arg113Cys Uncertain significance Single submitter
- PLAUR p.Arg167Cys Uncertain significance Single submitter
- PLAUR p.Arg214Cys Uncertain significance Single submitter
- PLAUR p.Arg80Pro Uncertain significance Single submitter
- PLAUR p.Asp124His Uncertain significance Single submitter
- PLAUR p.Glu90Lys Uncertain significance Single submitter
- PLAUR p.Gly101Cys Uncertain significance Single submitter
- PLAUR p.Ile85Thr Uncertain significance Single submitter
- PLAUR p.Leu321Arg Uncertain significance Single submitter
- PLAUR p.Met241Val Uncertain significance Single submitter
- PLAUR p.Ser87Arg Uncertain significance Single submitter
All PLAUR variants
Benign 1
- p.Thr248= Single submitter
Benign/Likely benign 1
- p.Pro8= Multiple submitters
Likely benign 10
- p.His251= Multiple submitters
- p.Met268Val Multiple submitters
- c.55+6G>T Single submitter
- p.Arg159His Single submitter
- p.Asn179Ser Single submitter
- p.Asp276= Single submitter
- p.Lys220Gln Single submitter
- p.Pro176= Single submitter
- p.Pro253Leu Single submitter
- p.Gly94Glu No assertion criteria PLAUR-related disorder
Uncertain significance 52
- p.Ala106Asp Single submitter ⚠
- p.Arg113Cys Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg131Gly Single submitter ⚠
- p.Arg164Cys Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg214Cys Single submitter ⚠
- p.Arg52Leu Single submitter ⚠
- p.Arg80Pro Single submitter ⚠
- p.Asn102Lys Single submitter ⚠
- p.Asn212Ser Single submitter ⚠
- p.Asp124His Single submitter ⚠
- p.Cys127Ser Single submitter ⚠
- p.Cys137Gly Single submitter ⚠
- p.Cys137Tyr Single submitter ⚠
- p.Cys28Tyr Single submitter ⚠
- p.Cys39Gly Single submitter ⚠
- p.Cys93Tyr Single submitter ⚠
- p.Glu200Lys Single submitter ⚠
- p.Glu230Gly Single submitter ⚠
- p.Glu38Gly Single submitter
- p.Glu56Val Single submitter ⚠
- p.Glu59Gly Single submitter ⚠
- p.Glu59Val Single submitter ⚠
- p.Glu61Asp Single submitter ⚠
- p.Glu90Gly Single submitter ⚠
- p.Glu90Lys Single submitter ⚠
- p.Gly101Cys Single submitter ⚠
- p.Gly170Asp Single submitter ⚠
- p.Gly239Ala Single submitter ⚠
- p.Gly239Val Single submitter ⚠
- p.Gly311Arg Single submitter ⚠
- p.Gly330Val Single submitter ⚠
- p.Gly82Ala Single submitter ⚠
- p.Ile283Thr Single submitter ⚠
- p.Ile85Thr Single submitter ⚠
- p.Ile85Val Single submitter ⚠
- p.Leu204Pro Single submitter ⚠
- p.Leu317Ile Single submitter ⚠
- p.Leu321Arg Single submitter ⚠
- p.Leu41Val Single submitter ⚠
- p.Met241Thr Single submitter ⚠
- p.Met241Val Single submitter ⚠
- p.Pro176Leu Single submitter ⚠
- p.Pro308Ser Single submitter ⚠
- p.Pro312His Single submitter ⚠
- p.Ser123Pro Single submitter ⚠
- p.Ser139Arg Single submitter ⚠
- p.Ser304Ile Single submitter ⚠
- p.Ser87Arg Single submitter ⚠
- p.Thr73Asn Single submitter ⚠
- p.Val91Leu Single submitter ⚠