PLD4 — 104 ClinVar variants
All ClinVar germline PLD4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
8 Likely benign · 96 Uncertain significance
Full PLD4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLD4 p.Ala109Val Uncertain significance Single submitter
- PLD4 p.Ala121Val Uncertain significance Single submitter
- PLD4 p.Ala177Thr Uncertain significance Single submitter
- PLD4 p.Ala195Thr Uncertain significance Single submitter
- PLD4 p.Ala245Thr Uncertain significance Single submitter
- PLD4 p.Ala326Val Uncertain significance Single submitter
- PLD4 p.Ala331Ser Uncertain significance Single submitter
- PLD4 p.Ala402Thr Uncertain significance Single submitter
- PLD4 p.Ala497Val Uncertain significance Single submitter
- PLD4 p.Ala79Val Uncertain significance Single submitter
- PLD4 p.Ala85Thr Uncertain significance Single submitter
- PLD4 p.Arg185Lys Uncertain significance Single submitter
- PLD4 p.Arg201Gln Uncertain significance Single submitter
- PLD4 p.Arg207Leu Uncertain significance Single submitter
- PLD4 p.Arg207Trp Uncertain significance Single submitter
- PLD4 p.Arg210Ser Uncertain significance Single submitter
- PLD4 p.Arg288His Uncertain significance Single submitter
- PLD4 p.Arg319Leu Uncertain significance Single submitter
- PLD4 p.Arg483Pro Uncertain significance Single submitter
- PLD4 p.Arg56Gly Uncertain significance Single submitter
- PLD4 p.Asn231His Uncertain significance Single submitter
- PLD4 p.Asn287Ser Uncertain significance Single submitter
- PLD4 p.Asp407Glu Uncertain significance Single submitter
- PLD4 p.Gln166Lys Uncertain significance Single submitter
- PLD4 p.Gln255Arg Uncertain significance Single submitter
- PLD4 p.Gln395Leu Uncertain significance Single submitter
- PLD4 p.Gln496Arg Uncertain significance Single submitter
- PLD4 p.Gln90Glu Uncertain significance Single submitter
- PLD4 p.Glu158Asp Uncertain significance Single submitter
- PLD4 p.Gly148Arg Uncertain significance Single submitter
- PLD4 p.Gly268Arg Uncertain significance Single submitter
- PLD4 p.Gly316Asp Uncertain significance Single submitter
- PLD4 p.Gly368Arg Uncertain significance Single submitter
- PLD4 p.Gly378Ala Uncertain significance Single submitter
- PLD4 p.Gly416Glu Uncertain significance Single submitter
- PLD4 p.Gly416Val Uncertain significance Single submitter
- PLD4 p.Gly455Glu Uncertain significance Single submitter
- PLD4 p.Ile440Val Uncertain significance Single submitter
- PLD4 p.Leu160Val Uncertain significance Single submitter
- PLD4 p.Leu164Met Uncertain significance Single submitter
- PLD4 p.Leu376Pro Uncertain significance Single submitter
- PLD4 p.Leu394Pro Uncertain significance Single submitter
- PLD4 p.Leu5Val Uncertain significance Single submitter
- PLD4 p.Lys369Asn Uncertain significance Single submitter
- PLD4 p.Met205Ile Uncertain significance Single submitter
- PLD4 p.Met227Thr Uncertain significance Single submitter
- PLD4 p.Pro204Leu Uncertain significance Single submitter
- PLD4 p.Pro352Thr Uncertain significance Single submitter
- PLD4 p.Pro400Ser Uncertain significance Single submitter
- PLD4 p.Pro82Ser Uncertain significance Single submitter
- PLD4 p.Ser108Thr Uncertain significance Single submitter
- PLD4 p.Ser215Ala Uncertain significance Single submitter
- PLD4 p.Ser229Arg Uncertain significance Single submitter
- PLD4 p.Thr345Ile Uncertain significance Single submitter
- PLD4 p.Thr442Ile Uncertain significance Single submitter
- PLD4 p.Thr472Arg Uncertain significance Single submitter
- PLD4 p.Trp140Arg Uncertain significance Single submitter
- PLD4 p.Trp60Cys Uncertain significance Single submitter
- PLD4 p.Trp60Ser Uncertain significance Single submitter
- PLD4 p.Tyr354Asp Uncertain significance Single submitter
- PLD4 p.Val133Ile Uncertain significance Single submitter
- PLD4 p.Val149Ile Uncertain significance Single submitter
- PLD4 p.Val269Leu Uncertain significance Single submitter
- PLD4 p.Val299Leu Uncertain significance Single submitter
- PLD4 p.Val339Leu Uncertain significance Single submitter
- PLD4 p.Val33Ile Uncertain significance Single submitter
- PLD4 p.Val408Met Uncertain significance Single submitter
- PLD4 p.Val415Gly Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- PLD4 p.Ala307Glu Uncertain significance Single submitter
- PLD4 p.Ala331Thr Uncertain significance Single submitter
- PLD4 p.Ala454Val Uncertain significance Single submitter
- PLD4 p.Arg223Trp Uncertain significance Single submitter
- PLD4 p.Arg235Gln Uncertain significance Single submitter
- PLD4 p.Arg347Pro Uncertain significance Single submitter
- PLD4 p.Asn360Ile Uncertain significance Single submitter
- PLD4 p.Asp189Asn Uncertain significance Single submitter
- PLD4 p.Asp484Glu Uncertain significance Single submitter
- PLD4 p.Leu123Pro Uncertain significance Single submitter
- PLD4 p.Leu161Arg Uncertain significance Single submitter
- PLD4 p.Leu167Pro Uncertain significance Single submitter
- PLD4 p.Phe296Leu Uncertain significance Single submitter
- PLD4 p.Phe343Leu Uncertain significance Single submitter
- PLD4 p.Pro181Leu Uncertain significance Single submitter
- PLD4 p.Pro314Leu Uncertain significance Single submitter
- PLD4 p.Ser152Trp Uncertain significance Single submitter
- PLD4 p.Ser153Phe Uncertain significance Single submitter
- PLD4 p.Ser338Thr Uncertain significance Single submitter
- PLD4 p.Val203Met Uncertain significance Single submitter
- PLD4 p.Val212Phe Uncertain significance Single submitter
- PLD4 p.Val339Met Uncertain significance Single submitter
- PLD4 p.Val456Met Uncertain significance Single submitter
- PLD4 p.Val459Met Uncertain significance Single submitter
All PLD4 variants
Likely benign 8
- c.468+4C>T Multiple submitters
- p.Ala36Val Single submitter
- p.Arg207Gln Single submitter
- p.Gln315His Single submitter
- p.His199Gln Single submitter
- p.His293Arg Single submitter
- p.Pro113Leu Single submitter
- p.Val45Met Single submitter
Uncertain significance 96
- p.Ala109Val Single submitter ⚠
- p.Ala121Val Single submitter ⚠
- p.Ala177Thr Single submitter ⚠
- p.Ala195Thr Single submitter ⚠
- p.Ala245Thr Single submitter ⚠
- p.Ala307Glu Single submitter ⚠
- p.Ala326Val Single submitter ⚠
- p.Ala331Ser Single submitter ⚠
- p.Ala331Thr Single submitter ⚠
- p.Ala402Thr Single submitter ⚠
- p.Ala454Val Single submitter ⚠
- p.Ala497Val Single submitter ⚠
- p.Ala79Val Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Arg185Lys Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Arg207Leu Single submitter ⚠
- p.Arg207Trp Single submitter ⚠
- p.Arg210Ser Single submitter ⚠
- p.Arg223Trp Single submitter ⚠
- p.Arg235Gln Single submitter ⚠
- p.Arg288His Single submitter ⚠
- p.Arg317His Single submitter
- p.Arg319fs Single submitter
- p.Arg319Leu Single submitter ⚠
- p.Arg347Pro Single submitter ⚠
- p.Arg483Pro Single submitter ⚠
- p.Arg56Gly Single submitter ⚠
- p.Asn231His Single submitter ⚠
- p.Asn287Ser Single submitter ⚠
- p.Asn360Ile Single submitter ⚠
- p.Asp189Asn Single submitter ⚠
- p.Asp407Glu Single submitter ⚠
- p.Asp484Glu Single submitter ⚠
- p.Gln166Lys Single submitter ⚠
- p.Gln255Arg Single submitter ⚠
- p.Gln395Leu Single submitter ⚠
- p.Gln496Arg Single submitter ⚠
- p.Gln90Glu Single submitter ⚠
- p.Glu158Asp Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.Gly268Arg Single submitter ⚠
- p.Gly316Asp Single submitter ⚠
- p.Gly368Arg Single submitter ⚠
- p.Gly378Ala Single submitter ⚠
- p.Gly416Glu Single submitter ⚠
- p.Gly416Val Single submitter ⚠
- p.Gly455Glu Single submitter ⚠
- p.His293Leu Single submitter systemic lupus erythematosus 18
- p.Ile440Val Single submitter ⚠
- p.Leu123Pro Single submitter ⚠
- p.Leu160Val Single submitter ⚠
- p.Leu161Arg Single submitter ⚠
- p.Leu164Met Single submitter ⚠
- p.Leu167Pro Single submitter ⚠
- p.Leu376Pro Single submitter ⚠
- p.Leu394Pro Single submitter ⚠
- p.Leu458Trp Single submitter
- p.Leu5Val Single submitter ⚠
- p.Lys369Asn Single submitter ⚠
- p.Met205Ile Single submitter ⚠
- p.Met227Thr Single submitter ⚠
- p.Phe296Leu Single submitter ⚠
- p.Phe343Leu Single submitter ⚠
- p.Pro181Leu Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Pro314Leu Single submitter ⚠
- p.Pro352Thr Single submitter ⚠
- p.Pro400Ser Single submitter ⚠
- p.Pro82Ser Single submitter ⚠
- p.Ser108Thr Single submitter ⚠
- p.Ser152Trp Single submitter ⚠
- p.Ser153Phe Single submitter ⚠
- p.Ser215Ala Single submitter ⚠
- p.Ser229Arg Single submitter ⚠
- p.Ser338Thr Single submitter ⚠
- p.Thr345Ile Single submitter ⚠
- p.Thr442Ile Single submitter ⚠
- p.Thr472Arg Single submitter ⚠
- p.Trp140Arg Single submitter ⚠
- p.Trp60Cys Single submitter ⚠
- p.Trp60Ser Single submitter ⚠
- p.Tyr354Asp Single submitter ⚠
- p.Val133Ile Single submitter ⚠
- p.Val149Ile Single submitter ⚠
- p.Val203Met Single submitter ⚠
- p.Val212Phe Single submitter ⚠
- p.Val269Leu Single submitter ⚠
- p.Val299Leu Single submitter ⚠
- p.Val339Leu Single submitter ⚠
- p.Val339Met Single submitter ⚠
- p.Val33Ile Single submitter ⚠
- p.Val408Met Single submitter ⚠
- p.Val415Gly Single submitter ⚠
- p.Val456Met Single submitter ⚠
- p.Val459Met Single submitter ⚠