Sugi Variant

Sugi Variant/PLG

PLG — 599 ClinVar variants

All ClinVar germline PLG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 278 flagged for review →

15 Pathogenic · 1 Pathogenic/Likely pathogenic · 14 Likely pathogenic · 15 Conflicting · 65 Benign · 13 Benign/Likely benign · 166 Likely benign · 310 Uncertain significance

Full PLG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 278

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 4

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 10

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 211

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 211

Predictors split 53

The independent predictors disagree with each other — read with care.

All PLG variants

Pathogenic 15

Pathogenic/Likely pathogenic 1

  • p.Lys38Glu Multiple submitters Thrombophilia with a likely monogenic cause ⚠

Likely pathogenic 14

Conflicting classifications of pathogenicity 15

Benign 65

Benign/Likely benign 13

Likely benign 166

Uncertain significance 310

Showing the top 300 by review status; the full set is in the sitemap.