PLIN3 — 97 ClinVar variants
All ClinVar germline PLIN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
2 Benign · 3 Likely benign · 92 Uncertain significance
Full PLIN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 73
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLIN3 p.Ala139Thr Uncertain significance Single submitter
- PLIN3 p.Ala212Val Uncertain significance Single submitter
- PLIN3 p.Ala215Thr Uncertain significance Single submitter
- PLIN3 p.Ala371Ser Uncertain significance Single submitter
- PLIN3 p.Ala397Thr Uncertain significance Single submitter
- PLIN3 p.Ala397Val Uncertain significance Single submitter
- PLIN3 p.Ala62Thr Uncertain significance Single submitter
- PLIN3 p.Ala72Val Uncertain significance Single submitter
- PLIN3 p.Ala73Thr Uncertain significance Single submitter
- PLIN3 p.Arg155His Uncertain significance Single submitter
- PLIN3 p.Arg180His Uncertain significance Single submitter
- PLIN3 p.Arg213His Uncertain significance Single submitter
- PLIN3 p.Arg230Trp Uncertain significance Single submitter
- PLIN3 p.Arg247Gln Uncertain significance Single submitter
- PLIN3 p.Arg264Thr Uncertain significance Single submitter
- PLIN3 p.Arg331Gln Uncertain significance Single submitter
- PLIN3 p.Arg363Cys Uncertain significance Single submitter
- PLIN3 p.Arg363Gly Uncertain significance Single submitter
- PLIN3 p.Arg363His Uncertain significance Single submitter
- PLIN3 p.Arg391Gly Uncertain significance Single submitter
- PLIN3 p.Arg391His Uncertain significance Single submitter
- PLIN3 p.Arg398Cys Uncertain significance Single submitter
- PLIN3 p.Arg398His Uncertain significance Single submitter
- PLIN3 p.Arg398Leu Uncertain significance Single submitter
- PLIN3 p.Arg68Thr Uncertain significance Single submitter
- PLIN3 p.Asp163Asn Uncertain significance Single submitter
- PLIN3 p.Asp402Asn Uncertain significance Single submitter
- PLIN3 p.Asp4His Uncertain significance Single submitter
- PLIN3 p.Asp9Asn Uncertain significance Single submitter
- PLIN3 p.Gln263Arg Uncertain significance Single submitter
- PLIN3 p.Gln321Glu Uncertain significance Single submitter
- PLIN3 p.Gln365Glu Uncertain significance Single submitter
- PLIN3 p.Glu149Asp Uncertain significance Single submitter
- PLIN3 p.Glu149Gln Uncertain significance Single submitter
- PLIN3 p.Glu313Lys Uncertain significance Single submitter
- PLIN3 p.Glu399Lys Uncertain significance Single submitter
- PLIN3 p.Gly156Ser Uncertain significance Single submitter
- PLIN3 p.Gly161Ser Uncertain significance Single submitter
- PLIN3 p.Gly220Val Uncertain significance Single submitter
- PLIN3 p.Gly285Asp Uncertain significance Single submitter
- PLIN3 p.Leu290Arg Uncertain significance Single submitter
- PLIN3 p.Leu337Arg Uncertain significance Single submitter
- PLIN3 p.Leu337Pro Uncertain significance Single submitter
- PLIN3 p.Lys128Glu Uncertain significance Single submitter
- PLIN3 p.Met184Ile Uncertain significance Single submitter
- PLIN3 p.Met329Thr Uncertain significance Single submitter
- PLIN3 p.Met329Val Uncertain significance Single submitter
- PLIN3 p.Met32Val Uncertain significance Single submitter
- PLIN3 p.Pro23Ser Uncertain significance Single submitter
- PLIN3 p.Pro430Leu Uncertain significance Single submitter
- PLIN3 p.Pro80Leu Uncertain significance Single submitter
- PLIN3 p.Ser130Leu Uncertain significance Single submitter
- PLIN3 p.Ser138Arg Uncertain significance Single submitter
- PLIN3 p.Ser148Leu Uncertain significance Single submitter
- PLIN3 p.Ser217Cys Uncertain significance Single submitter
- PLIN3 p.Ser243Leu Uncertain significance Single submitter
- PLIN3 p.Ser273Leu Uncertain significance Single submitter
- PLIN3 p.Ser277Gly Uncertain significance Single submitter
- PLIN3 p.Ser2Pro Uncertain significance Single submitter
- PLIN3 p.Ser347Gly Uncertain significance Single submitter
- PLIN3 p.Ser36Asn Uncertain significance Single submitter
- PLIN3 p.Thr191Arg Uncertain significance Single submitter
- PLIN3 p.Thr191Met Uncertain significance Single submitter
- PLIN3 p.Thr207Met Uncertain significance Single submitter
- PLIN3 p.Thr281Ala Uncertain significance Single submitter
- PLIN3 p.Thr340Ile Uncertain significance Single submitter
- PLIN3 p.Val162Leu Uncertain significance Single submitter
- PLIN3 p.Val168Ile Uncertain significance Single submitter
- PLIN3 p.Val173Ile Uncertain significance Single submitter
- PLIN3 p.Val286Gly Uncertain significance Single submitter
- PLIN3 p.Val286Ile Uncertain significance Single submitter
- PLIN3 p.Val359Glu Uncertain significance Single submitter
- PLIN3 p.Val418Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- PLIN3 p.Ala96Thr Uncertain significance Single submitter
- PLIN3 p.Arg155Cys Uncertain significance Single submitter
- PLIN3 p.Arg180Cys Uncertain significance Single submitter
- PLIN3 p.Arg247Trp Uncertain significance Single submitter
- PLIN3 p.Arg28Cys Uncertain significance Single submitter
- PLIN3 p.Arg28His Uncertain significance Single submitter
- PLIN3 p.Arg331Trp Uncertain significance Single submitter
- PLIN3 p.Arg393Cys Uncertain significance Single submitter
- PLIN3 p.Asp61Asn Uncertain significance Single submitter
- PLIN3 p.Glu197Lys Uncertain significance Single submitter
- PLIN3 p.Gly285Cys Uncertain significance Single submitter
- PLIN3 p.Gly66Glu Uncertain significance Single submitter
- PLIN3 p.Lys57Asn Uncertain significance Single submitter
- PLIN3 p.Ser175Leu Uncertain significance Single submitter
- PLIN3 p.Thr114Met Uncertain significance Single submitter
All PLIN3 variants
Likely benign 3
- p.Ala395Thr Single submitter
- p.Arg259Gln Single submitter
- p.Asp40Asn Single submitter
Uncertain significance 92
- p.Ala139Thr Single submitter ⚠
- p.Ala212Val Single submitter ⚠
- p.Ala215Thr Single submitter ⚠
- p.Ala371Ser Single submitter ⚠
- p.Ala397Thr Single submitter ⚠
- p.Ala397Val Single submitter ⚠
- p.Ala62Thr Single submitter ⚠
- p.Ala72Val Single submitter ⚠
- p.Ala73Thr Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg180Cys Single submitter ⚠
- p.Arg180His Single submitter ⚠
- p.Arg213His Single submitter ⚠
- p.Arg230Trp Single submitter ⚠
- p.Arg238Cys Single submitter
- p.Arg247Gln Single submitter ⚠
- p.Arg247Trp Single submitter ⚠
- p.Arg264Thr Single submitter ⚠
- p.Arg28Cys Single submitter ⚠
- p.Arg28His Single submitter ⚠
- p.Arg331Gln Single submitter ⚠
- p.Arg331Trp Single submitter ⚠
- p.Arg363Cys Single submitter ⚠
- p.Arg363Gly Single submitter ⚠
- p.Arg363His Single submitter ⚠
- p.Arg391Gly Single submitter ⚠
- p.Arg391His Single submitter ⚠
- p.Arg393Cys Single submitter ⚠
- p.Arg398Cys Single submitter ⚠
- p.Arg398His Single submitter ⚠
- p.Arg398Leu Single submitter ⚠
- p.Arg68Thr Single submitter ⚠
- p.Asp163Asn Single submitter ⚠
- p.Asp402Asn Single submitter ⚠
- p.Asp4His Single submitter ⚠
- p.Asp61Asn Single submitter ⚠
- p.Asp9Asn Single submitter ⚠
- p.Cys39Arg Single submitter
- p.Gln263Arg Single submitter ⚠
- p.Gln321Glu Single submitter ⚠
- p.Gln365Glu Single submitter ⚠
- p.Glu149Asp Single submitter ⚠
- p.Glu149Gln Single submitter ⚠
- p.Glu197Lys Single submitter ⚠
- p.Glu313Lys Single submitter ⚠
- p.Glu399Lys Single submitter ⚠
- p.Gly156Ser Single submitter ⚠
- p.Gly161Ser Single submitter ⚠
- p.Gly220Val Single submitter ⚠
- p.Gly285Asp Single submitter ⚠
- p.Gly285Cys Single submitter ⚠
- p.Gly66Glu Single submitter ⚠
- p.Leu290Arg Single submitter ⚠
- p.Leu337Arg Single submitter ⚠
- p.Leu337Pro Single submitter ⚠
- p.Lys128Glu Single submitter ⚠
- p.Lys57Asn Single submitter ⚠
- p.Met184Ile Single submitter ⚠
- p.Met329Thr Single submitter ⚠
- p.Met329Val Single submitter ⚠
- p.Met32Val Single submitter ⚠
- p.Pro108Leu Single submitter
- p.Pro23Ser Single submitter ⚠
- p.Pro352Ser Single submitter
- p.Pro430Leu Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser130Leu Single submitter ⚠
- p.Ser138Arg Single submitter ⚠
- p.Ser148Leu Single submitter ⚠
- p.Ser175Leu Single submitter ⚠
- p.Ser217Cys Single submitter ⚠
- p.Ser243Leu Single submitter ⚠
- p.Ser273Leu Single submitter ⚠
- p.Ser277Gly Single submitter ⚠
- p.Ser2Pro Single submitter ⚠
- p.Ser347Gly Single submitter ⚠
- p.Ser36Asn Single submitter ⚠
- p.Thr114Met Single submitter ⚠
- p.Thr191Arg Single submitter ⚠
- p.Thr191Met Single submitter ⚠
- p.Thr207Met Single submitter ⚠
- p.Thr281Ala Single submitter ⚠
- p.Thr340Ile Single submitter ⚠
- p.Val162Leu Single submitter ⚠
- p.Val168Ile Single submitter ⚠
- p.Val173Ile Single submitter ⚠
- p.Val286Gly Single submitter ⚠
- p.Val286Ile Single submitter ⚠
- p.Val359Glu Single submitter ⚠
- p.Val418Met Single submitter ⚠