PLK1 — 63 ClinVar variants
All ClinVar germline PLK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
1 Benign · 62 Uncertain significance
Full PLK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLK1 p.Ile327Thr Uncertain significance Multiple submitters
- PLK1 p.Ala34Pro Uncertain significance Single submitter
- PLK1 p.Ala583Thr Uncertain significance Single submitter
- PLK1 p.Arg135Trp Uncertain significance Single submitter
- PLK1 p.Arg354Leu Uncertain significance Single submitter
- PLK1 p.Arg356Gln Uncertain significance Single submitter
- PLK1 p.Arg364Gln Uncertain significance Single submitter
- PLK1 p.Arg560His Uncertain significance Single submitter
- PLK1 p.Arg594Cys Uncertain significance Single submitter
- PLK1 p.Arg594His Uncertain significance Single submitter
- PLK1 p.Arg599Cys Uncertain significance Single submitter
- PLK1 p.Asn297Ser Uncertain significance Single submitter
- PLK1 p.Asp376Glu Uncertain significance Single submitter
- PLK1 p.Asp588Glu Uncertain significance Single submitter
- PLK1 p.Gly205Trp Uncertain significance Single submitter
- PLK1 p.Gly21Val Uncertain significance Single submitter
- PLK1 p.His373Tyr Uncertain significance Single submitter
- PLK1 p.Ile296Val Uncertain significance Single submitter
- PLK1 p.Ile408Val Uncertain significance Single submitter
- PLK1 p.Ile553Phe Uncertain significance Single submitter
- PLK1 p.Ile83Val Uncertain significance Single submitter
- PLK1 p.Lys601Thr Uncertain significance Single submitter
- PLK1 p.Met100Leu Uncertain significance Single submitter
- PLK1 p.Pro17Ser Uncertain significance Single submitter
- PLK1 p.Pro28Ala Uncertain significance Single submitter
- PLK1 p.Ser331Asn Uncertain significance Single submitter
- PLK1 p.Ser390Leu Uncertain significance Single submitter
- PLK1 p.Val362Leu Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- PLK1 p.Ala26Thr Uncertain significance Single submitter
- PLK1 p.Ala279Thr Uncertain significance Single submitter
- PLK1 p.Ala30Thr Uncertain significance Single submitter
- PLK1 p.Ala386Val Uncertain significance Single submitter
- PLK1 p.Ala4Ser Uncertain significance Single submitter
- PLK1 p.Arg171Leu Uncertain significance Single submitter
- PLK1 p.Arg313Ser Uncertain significance Single submitter
- PLK1 p.Arg356Trp Uncertain significance Single submitter
- PLK1 p.Arg392Cys Uncertain significance Single submitter
- PLK1 p.Arg392His Uncertain significance Single submitter
- PLK1 p.Arg441His Uncertain significance Single submitter
- PLK1 p.Arg456His Uncertain significance Single submitter
- PLK1 p.Arg483His Uncertain significance Single submitter
- PLK1 p.Arg557Gln Uncertain significance Single submitter
- PLK1 p.Arg563Cys Uncertain significance Single submitter
- PLK1 p.Arg563His Uncertain significance Single submitter
- PLK1 p.Arg584Cys Uncertain significance Single submitter
- PLK1 p.Asn275Lys Uncertain significance Single submitter
- PLK1 p.Asn297Lys Uncertain significance Single submitter
- PLK1 p.Asp554Gly Uncertain significance Single submitter
- PLK1 p.Glu202Lys Uncertain significance Single submitter
- PLK1 p.Gly458Ser Uncertain significance Single submitter
- PLK1 p.Gly528Ser Uncertain significance Single submitter
- PLK1 p.Ile282Val Uncertain significance Single submitter
- PLK1 p.Leu505Phe Uncertain significance Single submitter
- PLK1 p.Pro36Leu Uncertain significance Single submitter
- PLK1 p.Pro499Leu Uncertain significance Single submitter
- PLK1 p.Pro92Arg Uncertain significance Single submitter
- PLK1 p.Ser466Arg Uncertain significance Single submitter
- PLK1 p.Thr498Lys Uncertain significance Single submitter
- PLK1 p.Val384Phe Uncertain significance Single submitter
- PLK1 p.Val530Met Uncertain significance Single submitter
-
PLK1 p.Val43Ala
Uncertain significance
No assertion criteria
Recurrent spontaneous abortion
All PLK1 variants
Benign 1
- p.Glu140= Multiple submitters
Uncertain significance 62
- p.Ile327Thr Multiple submitters ⚠
- p.Ala26Thr Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Ala34Pro Single submitter ⚠
- p.Ala386Val Single submitter ⚠
- p.Ala4Ser Single submitter ⚠
- p.Ala583Thr Single submitter ⚠
- p.Arg135Trp Single submitter ⚠
- p.Arg171Leu Single submitter ⚠
- p.Arg313Ser Single submitter ⚠
- p.Arg354Leu Single submitter ⚠
- p.Arg356Gln Single submitter ⚠
- p.Arg356Trp Single submitter ⚠
- p.Arg364Gln Single submitter ⚠
- p.Arg392Cys Single submitter ⚠
- p.Arg392His Single submitter ⚠
- p.Arg441His Single submitter ⚠
- p.Arg456His Single submitter ⚠
- p.Arg483His Single submitter ⚠
- p.Arg557Gln Single submitter ⚠
- p.Arg560His Single submitter ⚠
- p.Arg563Cys Single submitter ⚠
- p.Arg563His Single submitter ⚠
- p.Arg584Cys Single submitter ⚠
- p.Arg594Cys Single submitter ⚠
- p.Arg594His Single submitter ⚠
- p.Arg599Cys Single submitter ⚠
- p.Asn275Lys Single submitter ⚠
- p.Asn297Lys Single submitter ⚠
- p.Asn297Ser Single submitter ⚠
- p.Asp376Glu Single submitter ⚠
- p.Asp554Gly Single submitter ⚠
- p.Asp588Glu Single submitter ⚠
- p.Glu202Lys Single submitter ⚠
- p.Gly205Trp Single submitter ⚠
- p.Gly21Val Single submitter ⚠
- p.Gly458Ser Single submitter ⚠
- p.Gly528Ser Single submitter ⚠
- p.His373Tyr Single submitter ⚠
- p.Ile282Val Single submitter ⚠
- p.Ile296Val Single submitter ⚠
- p.Ile408Val Single submitter ⚠
- p.Ile553Phe Single submitter ⚠
- p.Ile83Val Single submitter ⚠
- p.Leu505Phe Single submitter ⚠
- p.Lys601Thr Single submitter ⚠
- p.Met100Leu Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro28Ala Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Pro499Leu Single submitter ⚠
- p.Pro92Arg Single submitter ⚠
- p.Ser331Asn Single submitter ⚠
- p.Ser390Leu Single submitter ⚠
- p.Ser439Ter Single submitter trichothiodystrophy
- p.Ser466Arg Single submitter ⚠
- p.Thr498Lys Single submitter ⚠
- p.Val362Leu Single submitter ⚠
- p.Val384Phe Single submitter ⚠
- p.Val530Met Single submitter ⚠
- p.Val43Ala No assertion criteria Recurrent spontaneous abortion ⚠