PLK2 — 37 ClinVar variants
All ClinVar germline PLK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Likely benign · 36 Uncertain significance
Full PLK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PLK2 p.Ala12Thr Uncertain significance Single submitter
- PLK2 p.Ala12Val Uncertain significance Single submitter
- PLK2 p.Ala434Thr Uncertain significance Single submitter
- PLK2 p.Ala54Val Uncertain significance Single submitter
- PLK2 p.Ala55Val Uncertain significance Single submitter
- PLK2 p.Arg596Gln Uncertain significance Single submitter
- PLK2 p.Asn105Ser Uncertain significance Single submitter
- PLK2 p.Asn647Ser Uncertain significance Single submitter
- PLK2 p.Asp29Asn Uncertain significance Single submitter
- PLK2 p.Cys96Phe Uncertain significance Single submitter
- PLK2 p.Gly25Cys Uncertain significance Single submitter
- PLK2 p.Ile113Thr Uncertain significance Single submitter
- PLK2 p.Ile441Thr Uncertain significance Single submitter
- PLK2 p.Ile492Val Uncertain significance Single submitter
- PLK2 p.Leu497Met Uncertain significance Single submitter
- PLK2 p.Lys33Gln Uncertain significance Single submitter
- PLK2 p.Lys494Glu Uncertain significance Single submitter
- PLK2 p.Lys542Glu Uncertain significance Single submitter
- PLK2 p.Met468Val Uncertain significance Single submitter
- PLK2 p.Met535Thr Uncertain significance Single submitter
- PLK2 p.Pro35Leu Uncertain significance Single submitter
- PLK2 p.Pro36Leu Uncertain significance Single submitter
- PLK2 p.Ser498Asn Uncertain significance Single submitter
- PLK2 p.Ser554Ala Uncertain significance Single submitter
- PLK2 p.Val435Ala Uncertain significance Single submitter
-
PLK2 p.Thr350Ile
Uncertain significance
No assertion criteria
esophageal atresia
Predictors split 9
The independent predictors disagree with each other — read with care.
- PLK2 p.Glu639Ala Uncertain significance Single submitter
- PLK2 p.Glu668Lys Uncertain significance Single submitter
- PLK2 p.His138Tyr Uncertain significance Single submitter
- PLK2 p.Leu479Phe Uncertain significance Single submitter
- PLK2 p.Leu642Val Uncertain significance Single submitter
- PLK2 p.Ser536Asn Uncertain significance Single submitter
- PLK2 p.Thr654Ala Uncertain significance Single submitter
- PLK2 p.Val51Met Uncertain significance Single submitter
- PLK2 p.Val525Ile Uncertain significance Single submitter
All PLK2 variants
Likely benign 1
- p.Ile595Thr Multiple submitters
Uncertain significance 36
- p.Ala12Thr Single submitter ⚠
- p.Ala12Val Single submitter ⚠
- p.Ala434Thr Single submitter ⚠
- p.Ala54Val Single submitter ⚠
- p.Ala55Val Single submitter ⚠
- p.Arg183Ter Single submitter
- p.Arg596Gln Single submitter ⚠
- p.Asn105Ser Single submitter ⚠
- p.Asn647Ser Single submitter ⚠
- p.Asp29Asn Single submitter ⚠
- p.Cys96Phe Single submitter ⚠
- p.Glu639Ala Single submitter ⚠
- p.Glu668Lys Single submitter ⚠
- p.Gly25Cys Single submitter ⚠
- p.His138Tyr Single submitter ⚠
- p.Ile113Thr Single submitter ⚠
- p.Ile441Thr Single submitter ⚠
- p.Ile492Val Single submitter ⚠
- p.Leu479Phe Single submitter ⚠
- p.Leu497Met Single submitter ⚠
- p.Leu642Val Single submitter ⚠
- p.Lys33Gln Single submitter ⚠
- p.Lys494Glu Single submitter ⚠
- p.Lys542Glu Single submitter ⚠
- p.Met468Val Single submitter ⚠
- p.Met535Thr Single submitter ⚠
- p.Pro35Leu Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Ser498Asn Single submitter ⚠
- p.Ser536Asn Single submitter ⚠
- p.Ser554Ala Single submitter ⚠
- p.Thr654Ala Single submitter ⚠
- p.Val435Ala Single submitter ⚠
- p.Val51Met Single submitter ⚠
- p.Val525Ile Single submitter ⚠
- p.Thr350Ile No assertion criteria esophageal atresia ⚠