PLK3 — 96 ClinVar variants

All ClinVar germline PLK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →

7 Benign · 4 Likely benign · 85 Uncertain significance

Full PLK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 83

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 61

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 22

The independent predictors disagree with each other — read with care.

All PLK3 variants

Benign 7

p.Gln383= Multiple submitters
c.949-4C>T Single submitter
p.Ala148= Single submitter
p.Ala496= Single submitter
p.Arg179= Single submitter
p.Glu267= Single submitter
p.Ser284= Single submitter

Likely benign 4

p.Ala292= Single submitter
p.Ala536Thr Single submitter
p.Ile325Val Single submitter
p.Val380Ile Single submitter

Uncertain significance 85

p.Ala293Ser Single submitter ⚠
p.Ala293Thr Single submitter ⚠
p.Ala415Gly Single submitter ⚠
p.Ala448Val Single submitter ⚠
p.Ala453Pro Single submitter ⚠
p.Ala572Gly Single submitter ⚠
p.Arg120Cys Single submitter ⚠
p.Arg154Gln Single submitter ⚠
p.Arg163Leu Single submitter ⚠
p.Arg167Gln Single submitter ⚠
p.Arg167Trp Single submitter ⚠
p.Arg179Cys Single submitter ⚠
p.Arg179His Single submitter ⚠
p.Arg184Trp Single submitter ⚠
p.Arg209Gln Single submitter ⚠
p.Arg288Leu Single submitter ⚠
p.Arg302Cys Single submitter ⚠
p.Arg302His Single submitter ⚠
p.Arg310Cys Single submitter ⚠
p.Arg310His Single submitter ⚠
p.Arg411Cys Single submitter ⚠
p.Arg411His Single submitter ⚠
p.Arg483Cys Single submitter ⚠
p.Arg483His Single submitter ⚠
p.Arg484Cys Single submitter ⚠
p.Arg51Pro Single submitter ⚠
p.Arg523Gln Single submitter ⚠
p.Arg523Pro Single submitter ⚠
p.Arg533Gln Single submitter ⚠
p.Arg533Trp Single submitter ⚠
p.Arg608Leu Single submitter ⚠
p.Arg641Leu Single submitter ⚠
p.Arg66Cys Single submitter ⚠
p.Arg75Gly Single submitter ⚠
p.Asp116Tyr Single submitter ⚠
p.Asp264Asn Single submitter ⚠
p.Asp384Val Single submitter ⚠
p.Cys271Tyr Single submitter ⚠
p.Cys613Gly Single submitter ⚠
p.Gln118Leu Single submitter ⚠
p.Gln457His Single submitter ⚠
p.Glu78Lys Single submitter ⚠
p.Gly202Trp Single submitter ⚠
p.Gly256Arg Single submitter ⚠
p.Gly370Ser Single submitter ⚠
p.Gly412Arg Single submitter ⚠
p.Gly588Arg Single submitter ⚠
p.Ile220Phe Single submitter ⚠
p.Leu309Pro Single submitter ⚠
p.Leu563Met Single submitter ⚠
p.Leu602Val Single submitter ⚠
p.Leu68Phe Single submitter ⚠
p.Lys273Glu Single submitter ⚠
p.Phe138Cys Single submitter ⚠
p.Phe204Leu Single submitter ⚠
p.Phe605Ser Single submitter ⚠
p.Pro101Arg Single submitter ⚠
p.Pro213Leu Single submitter ⚠
p.Pro299His Single submitter ⚠
p.Pro387Leu Single submitter ⚠
p.Pro452Leu Single submitter ⚠
p.Ser171Cys Single submitter ⚠
p.Ser257Asn Single submitter ⚠
p.Ser326Ile Single submitter ⚠
p.Ser482Arg Single submitter ⚠
p.Ser86Arg Single submitter ⚠
p.Thr262Ala Single submitter
p.Thr262Met Single submitter ⚠
p.Thr268Met Single submitter ⚠
p.Thr503Ile Single submitter ⚠
p.Thr569Met Single submitter ⚠
p.Thr614Ala Single submitter ⚠
p.Thr61Ser Single submitter ⚠
p.Tyr77Cys Single submitter ⚠
p.Tyr77His Single submitter ⚠
p.Tyr88Cys Single submitter ⚠
p.Val243Leu Single submitter ⚠
p.Val275Phe Single submitter
p.Val427Met Single submitter ⚠
p.Val468Leu Single submitter ⚠
p.Val521Ala Single submitter ⚠
p.Val555Ala Single submitter ⚠
p.Val557Ile Single submitter ⚠
p.Val582Ile Single submitter ⚠
p.Val606Gly Single submitter ⚠