POLB — 16 ClinVar variants
All ClinVar germline POLB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
16 Uncertain significance
Full POLB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- POLB p.Arg254Ile Uncertain significance Single submitter
- POLB p.Glu316Lys Uncertain significance Single submitter
- POLB p.Glu335Lys Uncertain significance Single submitter
- POLB p.Lys248Glu Uncertain significance Single submitter
- POLB p.Lys262Glu Uncertain significance Single submitter
- POLB p.Met191Ile Uncertain significance Single submitter
- POLB p.Met191Val Uncertain significance Single submitter
- POLB p.Phe200Val Uncertain significance Single submitter
- POLB p.Pro151Arg Uncertain significance Single submitter
- POLB p.Tyr322Asp Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- POLB p.Ala185Thr Uncertain significance Single submitter
- POLB p.Ala23Ser Uncertain significance Single submitter
- POLB p.Glu129Gly Uncertain significance Single submitter
- POLB p.His212Tyr Uncertain significance Single submitter
- POLB p.Ile119Val Uncertain significance Single submitter
- POLB p.Ser171Phe Uncertain significance Single submitter
All POLB variants
Uncertain significance 16
- p.Ala185Thr Single submitter ⚠
- p.Ala23Ser Single submitter ⚠
- p.Arg254Ile Single submitter ⚠
- p.Glu129Gly Single submitter ⚠
- p.Glu316Lys Single submitter ⚠
- p.Glu335Lys Single submitter ⚠
- p.His212Tyr Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Lys248Glu Single submitter ⚠
- p.Lys262Glu Single submitter ⚠
- p.Met191Ile Single submitter ⚠
- p.Met191Val Single submitter ⚠
- p.Phe200Val Single submitter ⚠
- p.Pro151Arg Single submitter ⚠
- p.Ser171Phe Single submitter ⚠
- p.Tyr322Asp Single submitter ⚠