POLE3 — 6 ClinVar variants
All ClinVar germline POLE3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
6 Uncertain significance
Full POLE3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- POLE3 p.Arg94Leu Uncertain significance Single submitter
- POLE3 p.Asn127Ser Uncertain significance Single submitter
- POLE3 p.Asp111Asn Uncertain significance Single submitter
- POLE3 p.Glu131Lys Uncertain significance Single submitter
- POLE3 p.Glu138Gln Uncertain significance Single submitter
- POLE3 p.Lys121Asn Uncertain significance Single submitter
All POLE3 variants
Uncertain significance 6
- p.Arg94Leu Single submitter ⚠
- p.Asn127Ser Single submitter ⚠
- p.Asp111Asn Single submitter ⚠
- p.Glu131Lys Single submitter ⚠
- p.Glu138Gln Single submitter ⚠
- p.Lys121Asn Single submitter ⚠