POLI — 105 ClinVar variants
All ClinVar germline POLI variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 97 flagged for review →
5 Likely benign · 100 Uncertain significance
Full POLI gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 97
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 84
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- POLI p.Ala23Thr Uncertain significance Single submitter
- POLI p.Ala351Ser Uncertain significance Single submitter
- POLI p.Ala564Asp Uncertain significance Single submitter
- POLI p.Arg126His Uncertain significance Single submitter
- POLI p.Arg126Pro Uncertain significance Single submitter
- POLI p.Arg373Gln Uncertain significance Single submitter
- POLI p.Arg633Gln Uncertain significance Single submitter
- POLI p.Asn259Ser Uncertain significance Single submitter
- POLI p.Asn315Asp Uncertain significance Single submitter
- POLI p.Asn437Asp Uncertain significance Single submitter
- POLI p.Asn442Thr Uncertain significance Single submitter
- POLI p.Asn508Asp Uncertain significance Single submitter
- POLI p.Asn92Lys Uncertain significance Single submitter
- POLI p.Asp20Gly Uncertain significance Single submitter
- POLI p.Asp410His Uncertain significance Single submitter
- POLI p.Asp42Gly Uncertain significance Single submitter
- POLI p.Asp472Glu Uncertain significance Single submitter
- POLI p.Asp472Tyr Uncertain significance Single submitter
- POLI p.Asp579Gly Uncertain significance Single submitter
- POLI p.Asp675Asn Uncertain significance Single submitter
- POLI p.Asp77His Uncertain significance Single submitter
- POLI p.Gln386Arg Uncertain significance Single submitter
- POLI p.Gln578Arg Uncertain significance Single submitter
- POLI p.Gln618Arg Uncertain significance Single submitter
- POLI p.Gln636Pro Uncertain significance Single submitter
- POLI p.Gln663Arg Uncertain significance Single submitter
- POLI p.Glu501Gln Uncertain significance Single submitter
- POLI p.Glu501Lys Uncertain significance Single submitter
- POLI p.Glu550Gly Uncertain significance Single submitter
- POLI p.Glu691Gly Uncertain significance Single submitter
- POLI p.Gly121Glu Uncertain significance Single submitter
- POLI p.Gly13Cys Uncertain significance Single submitter
- POLI p.Gly279Ala Uncertain significance Single submitter
- POLI p.Gly447Arg Uncertain significance Single submitter
- POLI p.His253Tyr Uncertain significance Single submitter
- POLI p.His379Asp Uncertain significance Single submitter
- POLI p.His686Leu Uncertain significance Single submitter
- POLI p.Ile196Met Uncertain significance Single submitter
- POLI p.Ile255Thr Uncertain significance Single submitter
- POLI p.Ile261Leu Uncertain significance Single submitter
- POLI p.Ile346Phe Uncertain significance Single submitter
- POLI p.Ile411Thr Uncertain significance Single submitter
- POLI p.Ile515Val Uncertain significance Single submitter
- POLI p.Ile582Val Uncertain significance Single submitter
- POLI p.Ile70Val Uncertain significance Single submitter
- POLI p.Leu190Val Uncertain significance Single submitter
- POLI p.Leu229Gln Uncertain significance Single submitter
- POLI p.Leu275Arg Uncertain significance Single submitter
- POLI p.Leu667Pro Uncertain significance Single submitter
- POLI p.Lys343Glu Uncertain significance Single submitter
- POLI p.Lys619Glu Uncertain significance Single submitter
- POLI p.Met104Arg Uncertain significance Single submitter
- POLI p.Met130Val Uncertain significance Single submitter
- POLI p.Met408Val Uncertain significance Single submitter
- POLI p.Met470Val Uncertain significance Single submitter
- POLI p.Met615Arg Uncertain significance Single submitter
- POLI p.Phe571Cys Uncertain significance Single submitter
- POLI p.Phe571Ser Uncertain significance Single submitter
- POLI p.Phe572Cys Uncertain significance Single submitter
- POLI p.Phe63Val Uncertain significance Single submitter
- POLI p.Phe713Leu Uncertain significance Single submitter
- POLI p.Pro291Leu Uncertain significance Single submitter
- POLI p.Pro651Arg Uncertain significance Single submitter
- POLI p.Ser142Arg Uncertain significance Single submitter
- POLI p.Ser179Leu Uncertain significance Single submitter
- POLI p.Ser432Asn Uncertain significance Single submitter
- POLI p.Ser570Pro Uncertain significance Single submitter
- POLI p.Ser590Gly Uncertain significance Single submitter
- POLI p.Ser617Thr Uncertain significance Single submitter
- POLI p.Ser669Phe Uncertain significance Single submitter
- POLI p.Ser697Pro Uncertain significance Single submitter
- POLI p.Ser71Leu Uncertain significance Single submitter
- POLI p.Thr125Ser Uncertain significance Single submitter
- POLI p.Thr244Ile Uncertain significance Single submitter
- POLI p.Thr484Arg Uncertain significance Single submitter
- POLI p.Thr674Ile Uncertain significance Single submitter
- POLI p.Thr690Arg Uncertain significance Single submitter
- POLI p.Tyr380Asn Uncertain significance Single submitter
- POLI p.Tyr621Phe Uncertain significance Single submitter
- POLI p.Val237Leu Uncertain significance Single submitter
- POLI p.Val56Leu Uncertain significance Single submitter
- POLI p.Val594Leu Uncertain significance Single submitter
- POLI p.Val597Ala Uncertain significance Single submitter
- POLI p.Val698Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- POLI p.Arg385Cys Uncertain significance Single submitter
- POLI p.Arg417Leu Uncertain significance Single submitter
- POLI p.Gln186Pro Uncertain significance Single submitter
- POLI p.His365Pro Uncertain significance Single submitter
- POLI p.Leu544Pro Uncertain significance Single submitter
- POLI p.Met104Thr Uncertain significance Single submitter
- POLI p.Met419Ile Uncertain significance Single submitter
- POLI p.Pro324Leu Uncertain significance Single submitter
- POLI p.Ser316Cys Uncertain significance Single submitter
- POLI p.Ser565Phe Uncertain significance Single submitter
- POLI p.Tyr374Cys Uncertain significance Single submitter
- POLI p.Tyr86Cys Uncertain significance Single submitter
- POLI p.Val420Glu Uncertain significance Single submitter
All POLI variants
Likely benign 5
- p.Ala655Val Single submitter
- p.Ile188Val Single submitter
- p.Ser591Arg Single submitter
- p.Tyr380Cys Single submitter
- p.Tyr623His Single submitter
Uncertain significance 100
- p.Ala23Thr Single submitter ⚠
- p.Ala351Ser Single submitter ⚠
- p.Ala564Asp Single submitter ⚠
- p.Arg126His Single submitter ⚠
- p.Arg126Pro Single submitter ⚠
- p.Arg373Gln Single submitter ⚠
- p.Arg382His Single submitter
- p.Arg385Cys Single submitter ⚠
- p.Arg417Leu Single submitter ⚠
- p.Arg633Gln Single submitter ⚠
- p.Asn259Ser Single submitter ⚠
- p.Asn315Asp Single submitter ⚠
- p.Asn437Asp Single submitter ⚠
- p.Asn442Thr Single submitter ⚠
- p.Asn508Asp Single submitter ⚠
- p.Asn92Lys Single submitter ⚠
- p.Asp20Gly Single submitter ⚠
- p.Asp410His Single submitter ⚠
- p.Asp42Gly Single submitter ⚠
- p.Asp472Glu Single submitter ⚠
- p.Asp472Tyr Single submitter ⚠
- p.Asp579Gly Single submitter ⚠
- p.Asp675Asn Single submitter ⚠
- p.Asp77His Single submitter ⚠
- p.Cys387Tyr Single submitter
- p.Gln186Pro Single submitter ⚠
- p.Gln386Arg Single submitter ⚠
- p.Gln578Arg Single submitter ⚠
- p.Gln618Arg Single submitter ⚠
- p.Gln636Pro Single submitter ⚠
- p.Gln663Arg Single submitter ⚠
- p.Glu501Gln Single submitter ⚠
- p.Glu501Lys Single submitter ⚠
- p.Glu550Gly Single submitter ⚠
- p.Glu691Gly Single submitter ⚠
- p.Gly121Glu Single submitter ⚠
- p.Gly13Cys Single submitter ⚠
- p.Gly279Ala Single submitter ⚠
- p.Gly447Arg Single submitter ⚠
- p.His253Tyr Single submitter ⚠
- p.His365Pro Single submitter ⚠
- p.His379Asp Single submitter ⚠
- p.His686Leu Single submitter ⚠
- p.Ile196Met Single submitter ⚠
- p.Ile255Thr Single submitter ⚠
- p.Ile261Leu Single submitter ⚠
- p.Ile346Phe Single submitter ⚠
- p.Ile411Thr Single submitter ⚠
- p.Ile515Val Single submitter ⚠
- p.Ile582Val Single submitter ⚠
- p.Ile70Val Single submitter ⚠
- p.Leu190Val Single submitter ⚠
- p.Leu229Gln Single submitter ⚠
- p.Leu275Arg Single submitter ⚠
- p.Leu544Pro Single submitter ⚠
- p.Leu667Pro Single submitter ⚠
- p.Lys343Glu Single submitter ⚠
- p.Lys619Glu Single submitter ⚠
- p.Met104Arg Single submitter ⚠
- p.Met104Thr Single submitter ⚠
- p.Met130Val Single submitter ⚠
- p.Met408Val Single submitter ⚠
- p.Met419Ile Single submitter ⚠
- p.Met419Thr Single submitter
- p.Met470Val Single submitter ⚠
- p.Met615Arg Single submitter ⚠
- p.Phe571Cys Single submitter ⚠
- p.Phe571Ser Single submitter ⚠
- p.Phe572Cys Single submitter ⚠
- p.Phe63Val Single submitter ⚠
- p.Phe713Leu Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Pro651Arg Single submitter ⚠
- p.Ser142Arg Single submitter ⚠
- p.Ser179Leu Single submitter ⚠
- p.Ser316Cys Single submitter ⚠
- p.Ser432Asn Single submitter ⚠
- p.Ser565Phe Single submitter ⚠
- p.Ser570Pro Single submitter ⚠
- p.Ser590Gly Single submitter ⚠
- p.Ser617Thr Single submitter ⚠
- p.Ser669Phe Single submitter ⚠
- p.Ser697Pro Single submitter ⚠
- p.Ser71Leu Single submitter ⚠
- p.Thr125Ser Single submitter ⚠
- p.Thr244Ile Single submitter ⚠
- p.Thr484Arg Single submitter ⚠
- p.Thr674Ile Single submitter ⚠
- p.Thr690Arg Single submitter ⚠
- p.Tyr374Cys Single submitter ⚠
- p.Tyr380Asn Single submitter ⚠
- p.Tyr621Phe Single submitter ⚠
- p.Tyr86Cys Single submitter ⚠
- p.Val237Leu Single submitter ⚠
- p.Val420Glu Single submitter ⚠
- p.Val56Leu Single submitter ⚠
- p.Val594Leu Single submitter ⚠
- p.Val597Ala Single submitter ⚠
- p.Val698Ile Single submitter ⚠