POLM — 78 ClinVar variants
All ClinVar germline POLM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
2 Benign · 8 Likely benign · 68 Uncertain significance
Full POLM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- POLM p.Ala384Thr Uncertain significance Single submitter
- POLM p.Ala400Gly Uncertain significance Single submitter
- POLM p.Ala51Glu Uncertain significance Single submitter
- POLM p.Ala61Ser Uncertain significance Single submitter
- POLM p.Ala61Val Uncertain significance Single submitter
- POLM p.Arg122Cys Uncertain significance Single submitter
- POLM p.Arg122His Uncertain significance Single submitter
- POLM p.Arg145His Uncertain significance Single submitter
- POLM p.Arg292Gln Uncertain significance Single submitter
- POLM p.Arg375Cys Uncertain significance Single submitter
- POLM p.Arg375Pro Uncertain significance Single submitter
- POLM p.Arg41Leu Uncertain significance Single submitter
- POLM p.Arg442Gln Uncertain significance Single submitter
- POLM p.Arg446Cys Uncertain significance Single submitter
- POLM p.Arg446Ser Uncertain significance Single submitter
- POLM p.Arg449Gln Uncertain significance Single submitter
- POLM p.Arg52His Uncertain significance Single submitter
- POLM p.Arg85His Uncertain significance Single submitter
- POLM p.Arg86Lys Uncertain significance Single submitter
- POLM p.Arg86Ser Uncertain significance Single submitter
- POLM p.Asp294Asn Uncertain significance Single submitter
- POLM p.Asp294Tyr Uncertain significance Single submitter
- POLM p.Asp463His Uncertain significance Single submitter
- POLM p.Asp60Asn Uncertain significance Single submitter
- POLM p.Gln242His Uncertain significance Single submitter
- POLM p.Glu207Gly Uncertain significance Single submitter
- POLM p.Glu371Asp Uncertain significance Single submitter
- POLM p.Glu490Gly Uncertain significance Single submitter
- POLM p.Gly155Asp Uncertain significance Single submitter
- POLM p.Gly403Glu Uncertain significance Single submitter
- POLM p.Gly93Asp Uncertain significance Single submitter
- POLM p.Ile360Met Uncertain significance Single submitter
- POLM p.Leu176Arg Uncertain significance Single submitter
- POLM p.Leu177Phe Uncertain significance Single submitter
- POLM p.Leu202His Uncertain significance Single submitter
- POLM p.Met382Val Uncertain significance Single submitter
- POLM p.Pro464Leu Uncertain significance Single submitter
- POLM p.Ser172Asn Uncertain significance Single submitter
- POLM p.Ser184Leu Uncertain significance Single submitter
- POLM p.Ser24Ala Uncertain significance Single submitter
- POLM p.Ser411Cys Uncertain significance Single submitter
- POLM p.Ser81Arg Uncertain significance Single submitter
- POLM p.Ser81Thr Uncertain significance Single submitter
- POLM p.Thr236Ala Uncertain significance Single submitter
- POLM p.Thr314Ala Uncertain significance Single submitter
- POLM p.Thr406Met Uncertain significance Single submitter
- POLM p.Thr95Ile Uncertain significance Single submitter
- POLM p.Trp137Arg Uncertain significance Single submitter
- POLM p.Val415Met Uncertain significance Single submitter
- POLM p.Val80Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- POLM p.Ala183Val Uncertain significance Single submitter
- POLM p.Arg122Gly Uncertain significance Single submitter
- POLM p.Arg175Cys Uncertain significance Single submitter
- POLM p.Arg256Trp Uncertain significance Single submitter
- POLM p.Arg292Gly Uncertain significance Single submitter
- POLM p.Arg292Trp Uncertain significance Single submitter
- POLM p.Arg442Trp Uncertain significance Single submitter
- POLM p.Arg445His Uncertain significance Single submitter
- POLM p.Arg5Trp Uncertain significance Single submitter
- POLM p.Gly220Ala Likely benign Single submitter
- POLM p.Leu482Met Uncertain significance Single submitter
- POLM p.Lys187Gln Uncertain significance Single submitter
- POLM p.Met237Thr Uncertain significance Single submitter
- POLM p.Met39Lys Uncertain significance Single submitter
- POLM p.Met71Ile Uncertain significance Single submitter
- POLM p.Pro289Ser Uncertain significance Single submitter
- POLM p.Pro97Gln Uncertain significance Single submitter
- POLM p.Ser19Tyr Uncertain significance Single submitter
All POLM variants
Benign 2
- c.1399-21del Single submitter
- p.Glu158= Single submitter
Likely benign 8
- p.Ala422Thr Single submitter
- p.Ala472Val Single submitter
- p.Arg230Cys Single submitter
- p.Cys62Tyr Single submitter
- p.Gly220Ala Single submitter ⚠
- p.Thr147= Single submitter
- p.Val221= Single submitter
- p.Val424Ile Single submitter
Uncertain significance 68
- p.Ala183Val Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Ala400Gly Single submitter ⚠
- p.Ala51Glu Single submitter ⚠
- p.Ala61Ser Single submitter ⚠
- p.Ala61Val Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg122Gly Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg175Cys Single submitter ⚠
- p.Arg256Trp Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg292Gly Single submitter ⚠
- p.Arg292Trp Single submitter ⚠
- p.Arg375Cys Single submitter ⚠
- p.Arg375Pro Single submitter ⚠
- p.Arg41Leu Single submitter ⚠
- p.Arg442Gln Single submitter ⚠
- p.Arg442Trp Single submitter ⚠
- p.Arg445His Single submitter ⚠
- p.Arg446Cys Single submitter ⚠
- p.Arg446Ser Single submitter ⚠
- p.Arg449Gln Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Arg85His Single submitter ⚠
- p.Arg86Lys Single submitter ⚠
- p.Arg86Ser Single submitter ⚠
- p.Asp294Asn Single submitter ⚠
- p.Asp294Tyr Single submitter ⚠
- p.Asp463His Single submitter ⚠
- p.Asp60Asn Single submitter ⚠
- p.Gln242His Single submitter ⚠
- p.Glu207Gly Single submitter ⚠
- p.Glu371Asp Single submitter ⚠
- p.Glu490Gly Single submitter ⚠
- p.Gly155Asp Single submitter ⚠
- p.Gly403Glu Single submitter ⚠
- p.Gly93Asp Single submitter ⚠
- p.Ile360Met Single submitter ⚠
- p.Leu176Arg Single submitter ⚠
- p.Leu177Phe Single submitter ⚠
- p.Leu202His Single submitter ⚠
- p.Leu482Met Single submitter ⚠
- p.Lys187Gln Single submitter ⚠
- p.Met237Thr Single submitter ⚠
- p.Met382Val Single submitter ⚠
- p.Met39Lys Single submitter ⚠
- p.Met71Ile Single submitter ⚠
- p.Pro289Ser Single submitter ⚠
- p.Pro464Leu Single submitter ⚠
- p.Pro97Gln Single submitter ⚠
- p.Ser172Asn Single submitter ⚠
- p.Ser184Leu Single submitter ⚠
- p.Ser19Tyr Single submitter ⚠
- p.Ser24Ala Single submitter ⚠
- p.Ser411Cys Single submitter ⚠
- p.Ser81Arg Single submitter ⚠
- p.Ser81Thr Single submitter ⚠
- p.Thr236Ala Single submitter ⚠
- p.Thr241Ile Single submitter
- p.Thr314Ala Single submitter ⚠
- p.Thr406Met Single submitter ⚠
- p.Thr95Ile Single submitter ⚠
- p.Trp137Arg Single submitter ⚠
- p.Val415Met Single submitter ⚠
- p.Val80Ile Single submitter ⚠