PPARD — 39 ClinVar variants
All ClinVar germline PPARD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
1 Likely benign · 38 Uncertain significance
Full PPARD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPARD p.Ala209Val Uncertain significance Single submitter
- PPARD p.Ala21Pro Uncertain significance Single submitter
- PPARD p.Ala292Thr Uncertain significance Single submitter
- PPARD p.Ala392Asp Uncertain significance Single submitter
- PPARD p.Arg103His Uncertain significance Single submitter
- PPARD p.Arg379His Uncertain significance Single submitter
- PPARD p.Asn30His Uncertain significance Single submitter
- PPARD p.Asp215Asn Uncertain significance Single submitter
- PPARD p.Gln171Glu Uncertain significance Single submitter
- PPARD p.Glu109Lys Uncertain significance Single submitter
- PPARD p.Glu426Gln Uncertain significance Single submitter
- PPARD p.Gly165Arg Uncertain significance Single submitter
- PPARD p.Gly68Ser Uncertain significance Single submitter
- PPARD p.Gly78Arg Uncertain significance Single submitter
- PPARD p.Ile241Met Uncertain significance Single submitter
- PPARD p.Ile297Val Uncertain significance Single submitter
- PPARD p.Lys398Met Uncertain significance Single submitter
- PPARD p.Met192Val Uncertain significance Single submitter
- PPARD p.Ser114Arg Uncertain significance Single submitter
- PPARD p.Ser66Ala Uncertain significance Single submitter
- PPARD p.Ser69Ile Uncertain significance Single submitter
- PPARD p.Thr208Arg Uncertain significance Single submitter
- PPARD p.Thr376Ser Uncertain significance Single submitter
- PPARD p.Val279Ala Uncertain significance Single submitter
- PPARD p.Val298Ile Uncertain significance Single submitter
- PPARD p.Val367Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- PPARD p.Ala158Val Uncertain significance Single submitter
- PPARD p.Arg113His Uncertain significance Single submitter
- PPARD p.Arg12Trp Uncertain significance Single submitter
- PPARD p.Arg318His Uncertain significance Single submitter
- PPARD p.Arg75Gln Uncertain significance Single submitter
- PPARD p.Asn169Lys Uncertain significance Single submitter
- PPARD p.Asn184Lys Uncertain significance Single submitter
- PPARD p.Glu412Lys Uncertain significance Single submitter
- PPARD p.Ile355Met Uncertain significance Single submitter
- PPARD p.Met403Thr Uncertain significance Single submitter
- PPARD p.Ser40Asn Uncertain significance Single submitter
- PPARD p.Tyr168Cys Uncertain significance Single submitter
All PPARD variants
Likely benign 1
- p.Ser428Leu Single submitter
Uncertain significance 38
- p.Ala158Val Single submitter ⚠
- p.Ala209Val Single submitter ⚠
- p.Ala21Pro Single submitter ⚠
- p.Ala292Thr Single submitter ⚠
- p.Ala392Asp Single submitter ⚠
- p.Arg103His Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg12Trp Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg379His Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Asn169Lys Single submitter ⚠
- p.Asn184Lys Single submitter ⚠
- p.Asn30His Single submitter ⚠
- p.Asp215Asn Single submitter ⚠
- p.Gln171Glu Single submitter ⚠
- p.Glu109Lys Single submitter ⚠
- p.Glu412Lys Single submitter ⚠
- p.Glu426Gln Single submitter ⚠
- p.Gly165Arg Single submitter ⚠
- p.Gly68Ser Single submitter ⚠
- p.Gly78Arg Single submitter ⚠
- p.Ile241Met Single submitter ⚠
- p.Ile297Val Single submitter ⚠
- p.Ile355Met Single submitter ⚠
- p.Lys398Met Single submitter ⚠
- p.Met192Val Single submitter ⚠
- p.Met403Thr Single submitter ⚠
- p.Ser114Arg Single submitter ⚠
- p.Ser40Asn Single submitter ⚠
- p.Ser66Ala Single submitter ⚠
- p.Ser69Ile Single submitter ⚠
- p.Thr208Arg Single submitter ⚠
- p.Thr376Ser Single submitter ⚠
- p.Tyr168Cys Single submitter ⚠
- p.Val279Ala Single submitter ⚠
- p.Val298Ile Single submitter ⚠
- p.Val367Ile Single submitter ⚠