PPIF — 19 ClinVar variants
All ClinVar germline PPIF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
19 Uncertain significance
Full PPIF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPIF p.Asp108Asn Uncertain significance Single submitter
- PPIF p.Asp162Gly Uncertain significance Single submitter
- PPIF p.Glu128Lys Uncertain significance Single submitter
- PPIF p.Gly117Arg Uncertain significance Single submitter
- PPIF p.Gly89Ser Uncertain significance Single submitter
- PPIF p.Gly92Ala Uncertain significance Single submitter
- PPIF p.Lys160Arg Uncertain significance Single submitter
- PPIF p.Phe109Leu Uncertain significance Single submitter
- PPIF p.Phe154Ile Uncertain significance Single submitter
- PPIF p.Ser152Ala Uncertain significance Single submitter
- PPIF p.Ser93Phe Uncertain significance Single submitter
- PPIF p.Thr110Ala Uncertain significance Single submitter
- PPIF p.Thr161Pro Uncertain significance Single submitter
- PPIF p.Thr83Ala Uncertain significance Single submitter
- PPIF p.Val135Met Uncertain significance Single submitter
- PPIF p.Val71Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All PPIF variants
Uncertain significance 19
- p.Arg124Cys Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp162Gly Single submitter ⚠
- p.Glu128Lys Single submitter ⚠
- p.Gly117Arg Single submitter ⚠
- p.Gly89Ser Single submitter ⚠
- p.Gly92Ala Single submitter ⚠
- p.Lys160Arg Single submitter ⚠
- p.Lys160Glu Single submitter ⚠
- p.Phe109Leu Single submitter ⚠
- p.Phe154Ile Single submitter ⚠
- p.Ser152Ala Single submitter ⚠
- p.Ser93Phe Single submitter ⚠
- p.Thr110Ala Single submitter ⚠
- p.Thr161Pro Single submitter ⚠
- p.Thr83Ala Single submitter ⚠
- p.Val135Met Single submitter ⚠
- p.Val139Ala Single submitter ⚠
- p.Val71Ile Single submitter ⚠