PPIG — 76 ClinVar variants
All ClinVar germline PPIG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
5 Benign · 3 Likely benign · 68 Uncertain significance
Full PPIG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPIG p.Ala542Thr Uncertain significance Single submitter
- PPIG p.Arg235Gln Uncertain significance Single submitter
- PPIG p.Arg239Gln Uncertain significance Single submitter
- PPIG p.Arg41His Uncertain significance Single submitter
- PPIG p.Arg436Lys Uncertain significance Single submitter
- PPIG p.Arg473Lys Uncertain significance Single submitter
- PPIG p.Arg600Thr Uncertain significance Single submitter
- PPIG p.Arg610Thr Uncertain significance Single submitter
- PPIG p.Arg625Trp Uncertain significance Single submitter
- PPIG p.Arg629Trp Uncertain significance Single submitter
- PPIG p.Arg669His Uncertain significance Single submitter
- PPIG p.Arg715Ile Uncertain significance Single submitter
- PPIG p.Asn657Asp Uncertain significance Single submitter
- PPIG p.Gln503Pro Uncertain significance Single submitter
- PPIG p.Gln694Leu Uncertain significance Single submitter
- PPIG p.Glu225Lys Uncertain significance Single submitter
- PPIG p.Glu303Asp Uncertain significance Single submitter
- PPIG p.Glu634Val Uncertain significance Single submitter
- PPIG p.Glu648Asp Uncertain significance Single submitter
- PPIG p.Glu710Gln Uncertain significance Single submitter
- PPIG p.Glu721Lys Uncertain significance Single submitter
- PPIG p.His429Asp Uncertain significance Single submitter
- PPIG p.His556Gln Uncertain significance Single submitter
- PPIG p.His580Arg Uncertain significance Single submitter
- PPIG p.His580Tyr Uncertain significance Single submitter
- PPIG p.His591Arg Uncertain significance Single submitter
- PPIG p.His591Tyr Uncertain significance Single submitter
- PPIG p.His671Arg Uncertain significance Single submitter
- PPIG p.His734Arg Uncertain significance Single submitter
- PPIG p.His742Asp Uncertain significance Single submitter
- PPIG p.Ile280Val Uncertain significance Single submitter
- PPIG p.Ile714Met Uncertain significance Single submitter
- PPIG p.Leu177Pro Uncertain significance Single submitter
- PPIG p.Leu388Trp Uncertain significance Single submitter
- PPIG p.Lys189Gln Uncertain significance Single submitter
- PPIG p.Lys521Thr Uncertain significance Single submitter
- PPIG p.Phe689Ser Uncertain significance Single submitter
- PPIG p.Pro268Ser Uncertain significance Single submitter
- PPIG p.Pro416Ser Uncertain significance Single submitter
- PPIG p.Ser375Leu Uncertain significance Single submitter
- PPIG p.Ser557Asn Uncertain significance Single submitter
- PPIG p.Ser557Gly Uncertain significance Single submitter
- PPIG p.Ser636Gly Uncertain significance Single submitter
- PPIG p.Ser666Pro Uncertain significance Single submitter
- PPIG p.Ser677Ile Uncertain significance Single submitter
- PPIG p.Thr223Ala Uncertain significance Single submitter
- PPIG p.Thr611Pro Uncertain significance Single submitter
- PPIG p.Tyr593Ser Uncertain significance Single submitter
- PPIG p.Tyr60Cys Uncertain significance Single submitter
- PPIG p.Tyr60His Uncertain significance Single submitter
- PPIG p.Val497Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- PPIG p.Arg350Lys Uncertain significance Single submitter
- PPIG p.Arg352His Uncertain significance Single submitter
- PPIG p.Arg541Cys Uncertain significance Single submitter
- PPIG p.Arg565Gln Uncertain significance Single submitter
- PPIG p.Arg584Cys Uncertain significance Single submitter
- PPIG p.Arg584Leu Uncertain significance Single submitter
- PPIG p.Arg605Gln Uncertain significance Single submitter
- PPIG p.Arg607Gln Uncertain significance Single submitter
- PPIG p.Arg669Cys Uncertain significance Single submitter
- PPIG p.Gly383Trp Uncertain significance Single submitter
- PPIG p.Lys385Asn Uncertain significance Single submitter
- PPIG p.Ser198Cys Uncertain significance Single submitter
- PPIG p.Ser221Ile Uncertain significance Single submitter
- PPIG p.Ser62Arg Uncertain significance Single submitter
- PPIG p.Val32Met Uncertain significance Single submitter
All PPIG variants
Benign 5
- c.929+11A>G Multiple submitters
- p.Asn672= Multiple submitters
- p.Glu495= Multiple submitters
- p.Thr54= Multiple submitters
- p.Gln637Glu Single submitter
Likely benign 3
- p.Gly136= Single submitter
- p.Lys231= Single submitter
- p.Pro612Thr Single submitter
Uncertain significance 68
- p.Ala542Thr Single submitter ⚠
- p.Arg235Gln Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg350Lys Single submitter ⚠
- p.Arg352His Single submitter ⚠
- p.Arg41His Single submitter ⚠
- p.Arg436Lys Single submitter ⚠
- p.Arg473Lys Single submitter ⚠
- p.Arg541Cys Single submitter ⚠
- p.Arg565Gln Single submitter ⚠
- p.Arg584Cys Single submitter ⚠
- p.Arg584Leu Single submitter ⚠
- p.Arg600Thr Single submitter ⚠
- p.Arg605Gln Single submitter ⚠
- p.Arg607Gln Single submitter ⚠
- p.Arg610Thr Single submitter ⚠
- p.Arg625Trp Single submitter ⚠
- p.Arg629Trp Single submitter ⚠
- p.Arg669Cys Single submitter ⚠
- p.Arg669His Single submitter ⚠
- p.Arg715Ile Single submitter ⚠
- p.Asn657Asp Single submitter ⚠
- p.Gln503Pro Single submitter ⚠
- p.Gln694Leu Single submitter ⚠
- p.Glu225Lys Single submitter ⚠
- p.Glu303Asp Single submitter ⚠
- p.Glu634Val Single submitter ⚠
- p.Glu648Asp Single submitter ⚠
- p.Glu710Gln Single submitter ⚠
- p.Glu721Lys Single submitter ⚠
- p.Gly383Trp Single submitter ⚠
- p.His429Asp Single submitter ⚠
- p.His556Gln Single submitter ⚠
- p.His580Arg Single submitter ⚠
- p.His580Tyr Single submitter ⚠
- p.His591Arg Single submitter ⚠
- p.His591Tyr Single submitter ⚠
- p.His671Arg Single submitter ⚠
- p.His734Arg Single submitter ⚠
- p.His742Asp Single submitter ⚠
- p.Ile280Val Single submitter ⚠
- p.Ile714Met Single submitter ⚠
- p.Leu177Pro Single submitter ⚠
- p.Leu388Trp Single submitter ⚠
- p.Lys189Gln Single submitter ⚠
- p.Lys385Asn Single submitter ⚠
- p.Lys521Thr Single submitter ⚠
- p.Met1Thr Single submitter
- p.Phe689Ser Single submitter ⚠
- p.Pro268Ser Single submitter ⚠
- p.Pro291Ser Single submitter
- p.Pro416Ser Single submitter ⚠
- p.Ser198Cys Single submitter ⚠
- p.Ser221Ile Single submitter ⚠
- p.Ser375Leu Single submitter ⚠
- p.Ser557Asn Single submitter ⚠
- p.Ser557Gly Single submitter ⚠
- p.Ser62Arg Single submitter ⚠
- p.Ser636Gly Single submitter ⚠
- p.Ser666Pro Single submitter ⚠
- p.Ser677Ile Single submitter ⚠
- p.Thr223Ala Single submitter ⚠
- p.Thr611Pro Single submitter ⚠
- p.Tyr593Ser Single submitter ⚠
- p.Tyr60Cys Single submitter ⚠
- p.Tyr60His Single submitter ⚠
- p.Val32Met Single submitter ⚠
- p.Val497Ala Single submitter ⚠