PPIH — 7 ClinVar variants
All ClinVar germline PPIH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
7 Uncertain significance
Full PPIH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 3
The independent predictors disagree with each other — read with care.
All PPIH variants
Uncertain significance 7
- p.Ala2Glu Single submitter ⚠
- p.Asn162Ser Single submitter ⚠
- p.Phe14Leu Single submitter ⚠
- p.Ser172Leu Single submitter ⚠
- p.Thr127Ile Single submitter ⚠
- p.Val12Met Single submitter ⚠
- p.Val24Ile Single submitter ⚠