PPM1A — 16 ClinVar variants
All ClinVar germline PPM1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
16 Uncertain significance
Full PPM1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPM1A p.Ala306Val Uncertain significance Single submitter
- PPM1A p.Asn363Ser Uncertain significance Single submitter
- PPM1A p.Asp262Glu Uncertain significance Single submitter
- PPM1A p.Asp372Asn Uncertain significance Single submitter
- PPM1A p.Cys314Trp Uncertain significance Single submitter
- PPM1A p.Glu307Asp Uncertain significance Single submitter
- PPM1A p.Ile320Leu Uncertain significance Single submitter
- PPM1A p.Ile320Thr Uncertain significance Single submitter
- PPM1A p.Ser298Leu Uncertain significance Single submitter
- PPM1A p.Thr261Ser Uncertain significance Single submitter
- PPM1A p.Val327Ile Uncertain significance Single submitter
- PPM1A p.Val331Ile Uncertain significance Single submitter
- PPM1A p.Val357Ile Uncertain significance Single submitter
- PPM1A p.Val361Ile Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All PPM1A variants
Uncertain significance 16
- p.Ala306Val Single submitter ⚠
- p.Asn363Ser Single submitter ⚠
- p.Asp262Glu Single submitter ⚠
- p.Asp262Gly Single submitter ⚠
- p.Asp372Asn Single submitter ⚠
- p.Cys314Trp Single submitter ⚠
- p.Glu307Asp Single submitter ⚠
- p.Ile320Leu Single submitter ⚠
- p.Ile320Thr Single submitter ⚠
- p.Ser298Leu Single submitter ⚠
- p.Thr261Ser Single submitter ⚠
- p.Thr66fs Single submitter
- p.Val327Ile Single submitter ⚠
- p.Val331Ile Single submitter ⚠
- p.Val357Ile Single submitter ⚠
- p.Val361Ile Single submitter ⚠