PPM1B — 63 ClinVar variants
All ClinVar germline PPM1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Benign · 8 Likely benign · 53 Uncertain significance
Full PPM1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPM1B p.Gln161Glu Uncertain significance Multiple submitters
- PPM1B p.Ala201Thr Uncertain significance Single submitter
- PPM1B p.Ala305Val Uncertain significance Single submitter
- PPM1B p.Ala344Thr Uncertain significance Single submitter
- PPM1B p.Ala395Thr Uncertain significance Single submitter
- PPM1B p.Ala433Pro Uncertain significance Single submitter
- PPM1B p.Ala461Asp Uncertain significance Single submitter
- PPM1B p.Arg153His Uncertain significance Single submitter
- PPM1B p.Arg319Trp Uncertain significance Single submitter
- PPM1B p.Arg340Cys Uncertain significance Single submitter
- PPM1B p.Asn125Ser Uncertain significance Single submitter
- PPM1B p.Asn270Ser Uncertain significance Single submitter
- PPM1B p.Asn273Ser Uncertain significance Single submitter
- PPM1B p.Asp38Glu Uncertain significance Single submitter
- PPM1B p.Gln398His Uncertain significance Single submitter
- PPM1B p.Glu178Lys Uncertain significance Single submitter
- PPM1B p.Glu317Gln Uncertain significance Single submitter
- PPM1B p.Glu329Asp Uncertain significance Single submitter
- PPM1B p.Glu329Lys Uncertain significance Single submitter
- PPM1B p.Glu83Lys Uncertain significance Single submitter
- PPM1B p.Gly160Arg Uncertain significance Single submitter
- PPM1B p.Gly283Arg Uncertain significance Single submitter
- PPM1B p.Gly331Glu Uncertain significance Single submitter
- PPM1B p.Gly425Arg Uncertain significance Single submitter
- PPM1B p.His48Arg Uncertain significance Single submitter
- PPM1B p.His74Tyr Uncertain significance Single submitter
- PPM1B p.His78Tyr Uncertain significance Single submitter
- PPM1B p.Ile238Thr Uncertain significance Single submitter
- PPM1B p.Leu392Phe Uncertain significance Single submitter
- PPM1B p.Lys326Glu Uncertain significance Single submitter
- PPM1B p.Met138Thr Uncertain significance Single submitter
- PPM1B p.Met332Ile Uncertain significance Single submitter
- PPM1B p.Pro348Ser Uncertain significance Single submitter
- PPM1B p.Ser327Phe Uncertain significance Single submitter
- PPM1B p.Ser417Gly Uncertain significance Single submitter
- PPM1B p.Ser466Tyr Uncertain significance Single submitter
- PPM1B p.Ser475Asn Uncertain significance Single submitter
- PPM1B p.Thr108Ala Uncertain significance Single submitter
- PPM1B p.Thr73Ile Uncertain significance Single submitter
- PPM1B p.Tyr145His Uncertain significance Single submitter
- PPM1B p.Tyr157Cys Uncertain significance Single submitter
- PPM1B p.Val43Ile Uncertain significance Single submitter
- PPM1B p.Val447Glu Uncertain significance Single submitter
- PPM1B p.Val447Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PPM1B p.Ala298Val Uncertain significance Single submitter
- PPM1B p.Arg23Cys Uncertain significance Single submitter
- PPM1B p.Arg408Gly Uncertain significance Single submitter
- PPM1B p.Asp277Glu Uncertain significance Single submitter
- PPM1B p.Gln190Glu Uncertain significance Single submitter
- PPM1B p.Lys9Gln Uncertain significance Single submitter
- PPM1B p.Ser165Phe Uncertain significance Single submitter
All PPM1B variants
Benign 2
- c.1134+10A>G Multiple submitters
- c.1134+14_1134+18del Single submitter
Likely benign 8
- p.Ala18Thr Single submitter
- p.Asn148= Single submitter
- p.Asp381Asn Single submitter
- p.Gln398= Single submitter
- p.Gly328= Single submitter
- p.Ser132= Single submitter
- p.Ser376Asn Single submitter
- p.Ser466Cys Single submitter
Uncertain significance 53
- p.Gln161Glu Multiple submitters ⚠
- p.Ala201Thr Single submitter ⚠
- p.Ala298Val Single submitter ⚠
- p.Ala305Val Single submitter ⚠
- p.Ala344Thr Single submitter ⚠
- p.Ala395Thr Single submitter ⚠
- p.Ala433Pro Single submitter ⚠
- p.Ala461Asp Single submitter ⚠
- p.Arg153His Single submitter ⚠
- p.Arg23Cys Single submitter ⚠
- p.Arg319Trp Single submitter ⚠
- p.Arg340Cys Single submitter ⚠
- p.Arg408Gly Single submitter ⚠
- p.Asn125Ser Single submitter ⚠
- p.Asn270Ser Single submitter ⚠
- p.Asn273Ser Single submitter ⚠
- p.Asp277Glu Single submitter ⚠
- p.Asp38Glu Single submitter ⚠
- p.Gln190Glu Single submitter ⚠
- p.Gln398His Single submitter ⚠
- p.Glu178Lys Single submitter ⚠
- p.Glu317Gln Single submitter ⚠
- p.Glu329Asp Single submitter ⚠
- p.Glu329Lys Single submitter ⚠
- p.Glu83Lys Single submitter ⚠
- p.Gly160Arg Single submitter ⚠
- p.Gly283Arg Single submitter ⚠
- p.Gly331Glu Single submitter ⚠
- p.Gly425Arg Single submitter ⚠
- p.His48Arg Single submitter ⚠
- p.His74Tyr Single submitter ⚠
- p.His78Tyr Single submitter ⚠
- p.Ile238Thr Single submitter ⚠
- p.Leu268Met Single submitter
- p.Leu392Phe Single submitter ⚠
- p.Lys326Glu Single submitter ⚠
- p.Lys9Gln Single submitter ⚠
- p.Met138Thr Single submitter ⚠
- p.Met332Ile Single submitter ⚠
- p.Pro348Ser Single submitter ⚠
- p.Ser165Phe Single submitter ⚠
- p.Ser327Phe Single submitter ⚠
- p.Ser343Phe Single submitter
- p.Ser417Gly Single submitter ⚠
- p.Ser466Tyr Single submitter ⚠
- p.Ser475Asn Single submitter ⚠
- p.Thr108Ala Single submitter ⚠
- p.Thr73Ile Single submitter ⚠
- p.Tyr145His Single submitter ⚠
- p.Tyr157Cys Single submitter ⚠
- p.Val43Ile Single submitter ⚠
- p.Val447Glu Single submitter ⚠
- p.Val447Leu Single submitter ⚠