PPM1G — 32 ClinVar variants
All ClinVar germline PPM1G variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
32 Uncertain significance
Full PPM1G gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPM1G p.Ala244Pro Uncertain significance Single submitter
- PPM1G p.Arg250Gln Uncertain significance Single submitter
- PPM1G p.Asn536Thr Uncertain significance Single submitter
- PPM1G p.Asn9Lys Uncertain significance Single submitter
- PPM1G p.Asp194Ala Uncertain significance Single submitter
- PPM1G p.Asp77Gly Uncertain significance Single submitter
- PPM1G p.Gln482His Uncertain significance Single submitter
- PPM1G p.Glu109Lys Uncertain significance Single submitter
- PPM1G p.Glu281Gln Uncertain significance Single submitter
- PPM1G p.Gly167Ser Uncertain significance Single submitter
- PPM1G p.Ile101Thr Uncertain significance Single submitter
- PPM1G p.Ile101Val Uncertain significance Single submitter
- PPM1G p.Leu513Val Uncertain significance Single submitter
- PPM1G p.Lys130Glu Uncertain significance Single submitter
- PPM1G p.Lys253Arg Uncertain significance Single submitter
- PPM1G p.Lys339Gln Uncertain significance Single submitter
- PPM1G p.Lys542Glu Uncertain significance Single submitter
- PPM1G p.Lys542Thr Uncertain significance Single submitter
- PPM1G p.Lys73Arg Uncertain significance Single submitter
- PPM1G p.Pro121Ser Uncertain significance Single submitter
- PPM1G p.Pro168Leu Uncertain significance Single submitter
- PPM1G p.Pro181Ala Uncertain significance Single submitter
- PPM1G p.Ser218Leu Uncertain significance Single submitter
- PPM1G p.Thr199Ser Uncertain significance Single submitter
- PPM1G p.Tyr364Cys Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PPM1G p.Asp136Gly Uncertain significance Single submitter
- PPM1G p.Glu263Lys Uncertain significance Single submitter
- PPM1G p.Glu477Asp Uncertain significance Single submitter
- PPM1G p.Ile456Phe Uncertain significance Single submitter
- PPM1G p.Lys73Thr Uncertain significance Single submitter
- PPM1G p.Ser260Arg Uncertain significance Single submitter
- PPM1G p.Thr329Ala Uncertain significance Single submitter
All PPM1G variants
Uncertain significance 32
- p.Ala244Pro Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Asn536Thr Single submitter ⚠
- p.Asn9Lys Single submitter ⚠
- p.Asp136Gly Single submitter ⚠
- p.Asp194Ala Single submitter ⚠
- p.Asp77Gly Single submitter ⚠
- p.Gln482His Single submitter ⚠
- p.Glu109Lys Single submitter ⚠
- p.Glu263Lys Single submitter ⚠
- p.Glu281Gln Single submitter ⚠
- p.Glu477Asp Single submitter ⚠
- p.Gly167Ser Single submitter ⚠
- p.Ile101Thr Single submitter ⚠
- p.Ile101Val Single submitter ⚠
- p.Ile456Phe Single submitter ⚠
- p.Leu513Val Single submitter ⚠
- p.Lys130Glu Single submitter ⚠
- p.Lys253Arg Single submitter ⚠
- p.Lys339Gln Single submitter ⚠
- p.Lys542Glu Single submitter ⚠
- p.Lys542Thr Single submitter ⚠
- p.Lys73Arg Single submitter ⚠
- p.Lys73Thr Single submitter ⚠
- p.Pro121Ser Single submitter ⚠
- p.Pro168Leu Single submitter ⚠
- p.Pro181Ala Single submitter ⚠
- p.Ser218Leu Single submitter ⚠
- p.Ser260Arg Single submitter ⚠
- p.Thr199Ser Single submitter ⚠
- p.Thr329Ala Single submitter ⚠
- p.Tyr364Cys Single submitter ⚠