PPP1R10 — 106 ClinVar variants
All ClinVar germline PPP1R10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →
3 Benign · 11 Likely benign · 92 Uncertain significance
Full PPP1R10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 91
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPP1R10 p.Ala153Gly Uncertain significance Single submitter
- PPP1R10 p.Ala153Val Uncertain significance Single submitter
- PPP1R10 p.Ala272Ser Uncertain significance Single submitter
- PPP1R10 p.Ala368Val Uncertain significance Single submitter
- PPP1R10 p.Arg183Gln Uncertain significance Single submitter
- PPP1R10 p.Arg465Trp Uncertain significance Single submitter
- PPP1R10 p.Arg483Gln Uncertain significance Single submitter
- PPP1R10 p.Arg665His Uncertain significance Single submitter
- PPP1R10 p.Arg688Gln Uncertain significance Single submitter
- PPP1R10 p.Arg738Gln Uncertain significance Single submitter
- PPP1R10 p.Asn479Ser Uncertain significance Single submitter
- PPP1R10 p.Asp139Asn Uncertain significance Single submitter
- PPP1R10 p.Glu186Asp Uncertain significance Single submitter
- PPP1R10 p.Glu403Ala Uncertain significance Single submitter
- PPP1R10 p.Glu513Gln Uncertain significance Single submitter
- PPP1R10 p.Glu525Asp Uncertain significance Single submitter
- PPP1R10 p.Gly540Ala Uncertain significance Single submitter
- PPP1R10 p.Gly621Ser Uncertain significance Single submitter
- PPP1R10 p.Gly743Arg Uncertain significance Single submitter
- PPP1R10 p.Gly869Asp Uncertain significance Single submitter
- PPP1R10 p.Gly890Arg Uncertain significance Single submitter
- PPP1R10 p.His595Arg Uncertain significance Single submitter
- PPP1R10 p.Ile241Val Uncertain significance Single submitter
- PPP1R10 p.Ile625Thr Uncertain significance Single submitter
- PPP1R10 p.Leu312Pro Uncertain significance Single submitter
- PPP1R10 p.Lys244Arg Uncertain significance Single submitter
- PPP1R10 p.Lys611Arg Uncertain significance Single submitter
- PPP1R10 p.Met347Thr Uncertain significance Single submitter
- PPP1R10 p.Met906Thr Uncertain significance Single submitter
- PPP1R10 p.Pro362Leu Uncertain significance Single submitter
- PPP1R10 p.Pro379Ala Uncertain significance Single submitter
- PPP1R10 p.Pro402Ala Uncertain significance Single submitter
- PPP1R10 p.Pro460Leu Uncertain significance Single submitter
- PPP1R10 p.Pro644Ser Uncertain significance Single submitter
- PPP1R10 p.Pro654Leu Uncertain significance Single submitter
- PPP1R10 p.Pro672Leu Uncertain significance Single submitter
- PPP1R10 p.Pro672Ser Uncertain significance Single submitter
- PPP1R10 p.Pro678Leu Uncertain significance Single submitter
- PPP1R10 p.Pro937Arg Uncertain significance Single submitter
- PPP1R10 p.Ser808Arg Uncertain significance Single submitter
- PPP1R10 p.Thr256Ile Uncertain significance Single submitter
- PPP1R10 p.Thr269Ala Uncertain significance Single submitter
- PPP1R10 p.Thr332Ala Uncertain significance Single submitter
- PPP1R10 p.Thr367Ser Uncertain significance Single submitter
- PPP1R10 p.Thr80Met Uncertain significance Single submitter
- PPP1R10 p.Val69Ile Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- PPP1R10 p.Ala432Val Uncertain significance Single submitter
- PPP1R10 p.Arg183Trp Uncertain significance Single submitter
- PPP1R10 p.Arg391Trp Uncertain significance Single submitter
- PPP1R10 p.Arg665Cys Uncertain significance Single submitter
- PPP1R10 p.Arg688Trp Uncertain significance Single submitter
- PPP1R10 p.Arg693Leu Uncertain significance Single submitter
- PPP1R10 p.Arg782His Uncertain significance Single submitter
- PPP1R10 p.Arg798Cys Uncertain significance Single submitter
- PPP1R10 p.Arg860Trp Uncertain significance Single submitter
- PPP1R10 p.Arg909Cys Uncertain significance Single submitter
- PPP1R10 p.Arg922His Uncertain significance Single submitter
- PPP1R10 p.Asp453Gly Uncertain significance Single submitter
- PPP1R10 p.Asp523Glu Uncertain significance Single submitter
- PPP1R10 p.Asp605Gly Uncertain significance Single submitter
- PPP1R10 p.Gln603Pro Uncertain significance Single submitter
- PPP1R10 p.Glu771Lys Uncertain significance Single submitter
- PPP1R10 p.Gly492Arg Uncertain significance Single submitter
- PPP1R10 p.Gly563Glu Uncertain significance Single submitter
- PPP1R10 p.Gly623Asp Uncertain significance Single submitter
- PPP1R10 p.Gly695Arg Uncertain significance Single submitter
- PPP1R10 p.Gly695Val Uncertain significance Single submitter
- PPP1R10 p.Gly728Val Uncertain significance Single submitter
- PPP1R10 p.Gly759Arg Uncertain significance Single submitter
- PPP1R10 p.Gly772Arg Uncertain significance Single submitter
- PPP1R10 p.Gly772Ser Uncertain significance Single submitter
- PPP1R10 p.Gly786Cys Uncertain significance Single submitter
- PPP1R10 p.Gly806Val Uncertain significance Single submitter
- PPP1R10 p.Gly812Ser Uncertain significance Single submitter
- PPP1R10 p.Gly837Arg Uncertain significance Single submitter
- PPP1R10 p.Gly895Glu Uncertain significance Single submitter
- PPP1R10 p.Gly936Val Uncertain significance Single submitter
- PPP1R10 p.His784Gln Uncertain significance Single submitter
- PPP1R10 p.His829Gln Uncertain significance Single submitter
- PPP1R10 p.His848Tyr Uncertain significance Single submitter
- PPP1R10 p.His862Tyr Uncertain significance Single submitter
- PPP1R10 p.Ile437Lys Uncertain significance Single submitter
- PPP1R10 p.Ile610Phe Uncertain significance Single submitter
- PPP1R10 p.Lys638Thr Uncertain significance Single submitter
- PPP1R10 p.Met589Val Uncertain significance Single submitter
- PPP1R10 p.Pro683Leu Uncertain significance Single submitter
- PPP1R10 p.Pro803Leu Uncertain significance Single submitter
- PPP1R10 p.Pro815Ala Uncertain significance Single submitter
- PPP1R10 p.Pro875Leu Uncertain significance Single submitter
- PPP1R10 p.Ser138Ile Uncertain significance Single submitter
- PPP1R10 p.Tyr930Cys Uncertain significance Single submitter
All PPP1R10 variants
Benign 3
- c.635-3C>T Single submitter
- p.Gly684= Single submitter
- p.Leu95= Single submitter
Likely benign 11
- p.Asn454Ser Single submitter
- p.Gly576Ala Single submitter
- p.Gly684Ala Single submitter
- p.Gly775Ser Single submitter
- p.Gly805Ser Single submitter
- p.Ile625Val Single submitter
- p.Pro362= Single submitter
- p.Ser228Asn Single submitter
- p.Val249Ile Single submitter
- p.Val468Ala Single submitter
- p.Val64Ala Single submitter
Uncertain significance 92
- c.-532-1G>C Single submitter
- p.Ala153Gly Single submitter ⚠
- p.Ala153Val Single submitter ⚠
- p.Ala272Ser Single submitter ⚠
- p.Ala368Val Single submitter ⚠
- p.Ala432Val Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg183Trp Single submitter ⚠
- p.Arg391Trp Single submitter ⚠
- p.Arg465Trp Single submitter ⚠
- p.Arg483Gln Single submitter ⚠
- p.Arg665Cys Single submitter ⚠
- p.Arg665His Single submitter ⚠
- p.Arg688Gln Single submitter ⚠
- p.Arg688Trp Single submitter ⚠
- p.Arg693Leu Single submitter ⚠
- p.Arg738Gln Single submitter ⚠
- p.Arg782His Single submitter ⚠
- p.Arg798Cys Single submitter ⚠
- p.Arg860Trp Single submitter ⚠
- p.Arg909Cys Single submitter ⚠
- p.Arg922His Single submitter ⚠
- p.Asn479Ser Single submitter ⚠
- p.Asp139Asn Single submitter ⚠
- p.Asp453Gly Single submitter ⚠
- p.Asp523Glu Single submitter ⚠
- p.Asp605Gly Single submitter ⚠
- p.Gln603Pro Single submitter ⚠
- p.Glu186Asp Single submitter ⚠
- p.Glu403Ala Single submitter ⚠
- p.Glu513Gln Single submitter ⚠
- p.Glu525Asp Single submitter ⚠
- p.Glu771Lys Single submitter ⚠
- p.Gly492Arg Single submitter ⚠
- p.Gly540Ala Single submitter ⚠
- p.Gly563Glu Single submitter ⚠
- p.Gly621Ser Single submitter ⚠
- p.Gly623Asp Single submitter ⚠
- p.Gly695Arg Single submitter ⚠
- p.Gly695Val Single submitter ⚠
- p.Gly728Val Single submitter ⚠
- p.Gly743Arg Single submitter ⚠
- p.Gly759Arg Single submitter ⚠
- p.Gly772Arg Single submitter ⚠
- p.Gly772Ser Single submitter ⚠
- p.Gly786Cys Single submitter ⚠
- p.Gly806Val Single submitter ⚠
- p.Gly812Ser Single submitter ⚠
- p.Gly837Arg Single submitter ⚠
- p.Gly869Asp Single submitter ⚠
- p.Gly890Arg Single submitter ⚠
- p.Gly895Glu Single submitter ⚠
- p.Gly936Val Single submitter ⚠
- p.His595Arg Single submitter ⚠
- p.His784Gln Single submitter ⚠
- p.His829Gln Single submitter ⚠
- p.His848Tyr Single submitter ⚠
- p.His862Tyr Single submitter ⚠
- p.Ile241Val Single submitter ⚠
- p.Ile437Lys Single submitter ⚠
- p.Ile610Phe Single submitter ⚠
- p.Ile625Thr Single submitter ⚠
- p.Leu312Pro Single submitter ⚠
- p.Lys244Arg Single submitter ⚠
- p.Lys611Arg Single submitter ⚠
- p.Lys638Thr Single submitter ⚠
- p.Met347Thr Single submitter ⚠
- p.Met589Val Single submitter ⚠
- p.Met906Thr Single submitter ⚠
- p.Pro362Leu Single submitter ⚠
- p.Pro379Ala Single submitter ⚠
- p.Pro402Ala Single submitter ⚠
- p.Pro460Leu Single submitter ⚠
- p.Pro644Ser Single submitter ⚠
- p.Pro654Leu Single submitter ⚠
- p.Pro672Leu Single submitter ⚠
- p.Pro672Ser Single submitter ⚠
- p.Pro678Leu Single submitter ⚠
- p.Pro683Leu Single submitter ⚠
- p.Pro803Leu Single submitter ⚠
- p.Pro815Ala Single submitter ⚠
- p.Pro875Leu Single submitter ⚠
- p.Pro937Arg Single submitter ⚠
- p.Ser138Ile Single submitter ⚠
- p.Ser808Arg Single submitter ⚠
- p.Thr256Ile Single submitter ⚠
- p.Thr269Ala Single submitter ⚠
- p.Thr332Ala Single submitter ⚠
- p.Thr367Ser Single submitter ⚠
- p.Thr80Met Single submitter ⚠
- p.Tyr930Cys Single submitter ⚠
- p.Val69Ile Single submitter ⚠