PPP2R5A — 36 ClinVar variants
All ClinVar germline PPP2R5A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
36 Uncertain significance
Full PPP2R5A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PPP2R5A p.Ala13Val Uncertain significance Single submitter
- PPP2R5A p.Ala261Thr Uncertain significance Single submitter
- PPP2R5A p.Ala32Thr Uncertain significance Single submitter
- PPP2R5A p.Arg441Lys Uncertain significance Single submitter
- PPP2R5A p.Arg451Leu Uncertain significance Single submitter
- PPP2R5A p.Arg45Leu Uncertain significance Single submitter
- PPP2R5A p.Asn65Ser Uncertain significance Single submitter
- PPP2R5A p.Asp185His Uncertain significance Single submitter
- PPP2R5A p.Asp61Gly Uncertain significance Single submitter
- PPP2R5A p.Cys79Tyr Uncertain significance Single submitter
- PPP2R5A p.Gln73Lys Uncertain significance Single submitter
- PPP2R5A p.Gln77Lys Uncertain significance Single submitter
- PPP2R5A p.Glu117Lys Uncertain significance Single submitter
- PPP2R5A p.Glu349Lys Uncertain significance Single submitter
- PPP2R5A p.Glu486Lys Uncertain significance Single submitter
- PPP2R5A p.Gly48Ser Uncertain significance Single submitter
- PPP2R5A p.His477Pro Uncertain significance Single submitter
- PPP2R5A p.Ile340Val Uncertain significance Single submitter
- PPP2R5A p.Ile348Thr Uncertain significance Single submitter
- PPP2R5A p.Ile411Thr Uncertain significance Single submitter
- PPP2R5A p.Ile96Val Uncertain significance Single submitter
- PPP2R5A p.Lys446Arg Uncertain significance Single submitter
- PPP2R5A p.Phe224Leu Uncertain significance Single submitter
- PPP2R5A p.Ser12Gly Uncertain significance Single submitter
- PPP2R5A p.Ser38Thr Uncertain significance Single submitter
- PPP2R5A p.Ser49Thr Uncertain significance Single submitter
- PPP2R5A p.Thr304Ser Uncertain significance Single submitter
- PPP2R5A p.Val189Ile Uncertain significance Single submitter
- PPP2R5A p.Val360Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PPP2R5A p.Ala290Thr Uncertain significance Single submitter
- PPP2R5A p.Asn417Ser Uncertain significance Single submitter
- PPP2R5A p.Gly23Arg Uncertain significance Single submitter
- PPP2R5A p.Thr100Ile Uncertain significance Single submitter
- PPP2R5A p.Thr151Met Uncertain significance Single submitter
- PPP2R5A p.Tyr183Cys Uncertain significance Single submitter
- PPP2R5A p.Val88Ala Uncertain significance Single submitter
All PPP2R5A variants
Uncertain significance 36
- p.Ala13Val Single submitter ⚠
- p.Ala261Thr Single submitter ⚠
- p.Ala290Thr Single submitter ⚠
- p.Ala32Thr Single submitter ⚠
- p.Arg441Lys Single submitter ⚠
- p.Arg451Leu Single submitter ⚠
- p.Arg45Leu Single submitter ⚠
- p.Asn417Ser Single submitter ⚠
- p.Asn65Ser Single submitter ⚠
- p.Asp185His Single submitter ⚠
- p.Asp61Gly Single submitter ⚠
- p.Cys79Tyr Single submitter ⚠
- p.Gln73Lys Single submitter ⚠
- p.Gln77Lys Single submitter ⚠
- p.Glu117Lys Single submitter ⚠
- p.Glu349Lys Single submitter ⚠
- p.Glu486Lys Single submitter ⚠
- p.Gly23Arg Single submitter ⚠
- p.Gly48Ser Single submitter ⚠
- p.His477Pro Single submitter ⚠
- p.Ile340Val Single submitter ⚠
- p.Ile348Thr Single submitter ⚠
- p.Ile411Thr Single submitter ⚠
- p.Ile96Val Single submitter ⚠
- p.Lys446Arg Single submitter ⚠
- p.Phe224Leu Single submitter ⚠
- p.Ser12Gly Single submitter ⚠
- p.Ser38Thr Single submitter ⚠
- p.Ser49Thr Single submitter ⚠
- p.Thr100Ile Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr304Ser Single submitter ⚠
- p.Tyr183Cys Single submitter ⚠
- p.Val189Ile Single submitter ⚠
- p.Val360Ile Single submitter ⚠
- p.Val88Ala Single submitter ⚠